PRİMER SUBMANDİBULAR BEZ MALİGN MUKOZAYLA İLİŞKİLİ LENFOİD DOKU (MALT) LENFOMASI: OLGU SUNUMU

Yıl 2010, Cilt: 43 Sayı: 2, 2 - 3, 01.08.2010

Ferhat Bozkuş İsmail İynen İmran Şan Muhammet Emin Güldür

Öz

Primary lymphomas of the salivary glands are uncommon. Primary malignant lymphomas of the salivary gland are predominantly B-cell type lymphomas. Mucosa associated lymphoid tissue (MALT) lymphomas are B-cell extranodal non-Hodgkin's lymphomas. MALT lymphomas are the most common lymphomas involving the salivary glands. MALT- lymphomas arises in extranodal sites such as the gastrointestinal tract, thyroid and salivary glands. The surgical resection have a important role in the diagnosis and treatment of the MALT lymphomas. We present a 65 year old man with painless enlargement on the neck admitted to our clinic. As a result of the examination and tests the patient was operated with the first diagnosis of submandibular benign mass. MALT lenfoma of submandibular gland origin was diagnosed resulting in histopathological analysis of the surgical specimen.

Anahtar Kelimeler

Mucosa-associated lymphoid tissue lymphoma, submandibular gland, histopathologic findings

Primary Submandibular Gland Malign Mucosa Associated Lymphoid Tissue (MALT) Lymphoma: Case Report

Öz

Tükürük bezlerinin primer lenfomaları oldukça nadir görülür. Tükürük bezlerinin primer malign lenfomalarında ağırlıklı olarak B hücre tipi lenfomalar bulunur. Mukozayla ilişkili lenfoid doku (MALT) lenfomaları B hücreli ekstranodal non-Hodgkin lenfomalardır. MALT lenfomaları tükürük bezini tutan lenfomalar içinde en sık görülenidir. MALT lenfomalar gastrointestinal yol, tiroid ve tükürük bezleri gibi ekstranodal bölgelerden kaynaklanır. MALT lenfomalarının tanı ve tedavisinde cerrahi eksizyonun önemli bir rolü bulunmaktadır. Kliniğimize boyunda ağrısız şişlik şikayetiyle başvuran, yapılan muayene ve tetkikler sonucunda submandibular benign kitle ön tanısı ile opere edilen, cerrahi spesimenin histopatolojik incelemesi sonucunda primer submandibular bez kaynaklı malign MALT lenfoması tanısı konulan 65 yaşında erkek hasta sunulmuştur.

Anahtar Kelimeler

Mukozayla ilişkili lenfoid doku lenfoması, submandibular bez, histopatolojik bulgular

Kaynakça

• FaurA, Lazar E, Cornianu M, Dema A, Lâzureanu C, Muresarı A, et al. Primary malign ant non-Hodgkin's lymphomas of sali­ vary glands. Rom J Morphol Embryol 2009; 50:693-9.
• Kojima M, Shimizu K, Nishikawa M, Tamaki Y, Ito H, Tsuka- moto N, et al. Primary salivary gland lymphoma among Japa- nese: a clinicopathological study of 30 cases. Leuk Lympho­ ma 2007; 48:1793-8.
• Toso A, Aluffi P, Capello D, Conconi A, Gaidano G, Pia F. Clini- cal and molecular features of mucosa-associated lymphoid tissue (MALT) lymphomas of salivary glands. Head Neck 2009;31:1181-7.
• Roh JL, Huh J, Suh C. Primary non-Hodgkin’s lymphomas of majör salivary glands. J Surg Oncol 2008; 97:35-9.
• Precerutti M, Solda M, Vercelli A, Azzaretti A, Draghi F, Rod- olico G. Parenchymal and nodal salivary glands lymphomas: differantial diagnosis by ultrasonography color and power Doppier. International Congress Series 2003; 1240:649-54.
• Tsang RW, Gospodarowicz MK, Pintilie M, et al. Localized mucosa-associated lymphoid tissue lymphoma treated vvith radiation therapy has exceiient clinical outcome. J Clin Oncol 2003; 21:4157-64.
• Takahashi H, Cheng J, Fujita S, et al. Primary malignant lym­ phoma of the salivary gland: a tumor of mucosa- associated lymphoid tissue. J Oral Pathol Med 1992; 21:318-25.
• VVenzel C, Fiebiger W, Dieckmann K, et al. Extranodal mar- ginal zone B- celi lymphoma of mucosa-associated lymphoid tissue of the head and neck area: high rate of disease recur- rence follovving local threapy. Cancer 2003; 97:2236-41.