Analysis of Second Primary Lung Cancers Developed Following Different System Tumors

Yıl 2013, Cilt: 46 Sayı: 1, 1 - 7, 01.04.2013

Çiğdem Özdilekcan Sevim Turanlı Necla Songür Hüseyin Çakmak

https://doi.org/10.5505/aot.2013.36844

Öz

OBJECTIVE: This study aimed to investigate clinical characteristics and prognosis of secondarily developed lung tumors in the cases having different system malignancy and to evaluate the relationship with the primary tumor.METHODS: Between January 2002- December 2010 thirty patients diagnosed as second primary lung cancer have been included in the study. The patients were grouped according to lung cancer development time; synchronous group (n: 7 patients, 16.7%) and metachronous group (n: 23 patients, 83.3%). RESULTS: Second cancer was detected in 50% of the patients within the first 2.5 years. Majority of patients had extra pulmonary cancer history concerning their relatives (43.3%). The rate of quitting smoking among all patients before the diagnosis of lung cancer was 50 %, current smoker rate was 30 % and never smoker was 20%. There was no statistical relationship between the response to treatment of first cancer and the duration of cancer developed secondarily (p=0.36). The overall survival of groups was found 24 months (95% confidence interval: 18.30 months) and 12 months (95% confidence interval: 10-14 months) respectively for synchronous and metachronous groups. CONCLUSION: Close follow-up on pulmonary system especially within the first 2.5 years after primary disease and encouragement on quitting smoking is important.

Anahtar Kelimeler

Lung carcinoma, second primary; synchronous; metachronous

Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi

Öz

AMAÇ: Bu çalışmada farklı sistem malignitelerine sekonder olarak gelişen akciğer tümörlerin klinik özellikleri ve primer tümörle olan ilişkilerinin araştırılması amaçlandı.YÖNTEMLER: 2002-2010 yılları arasında takipleri sırasında ikinci primer kanser tanısı alan otuz hasta çalışmaya dahil edildi. Hastalar, akciğer kanseri gelişme sürelerine göre senkron (n: 7 hasta, %16,7)ve metakron (N.23 Hasta, %83,3) grup olarak iki grupta değerlendirildi.BULGULAR: Hastaların %50sinde ilk 2.5 yıl içinde ikinci primer kanser saptandı. Hastaların çoğunluğunun (%43.3) akrabalarında ekstra pulmoner kanser öyküsü vardı. Akciğer kanseri tanısı konulan hastalardan %50sinde sigarayı bırakma, %30unda aktif içici ve %20sinde hiç sigara kullanmamış olma öyküsü vardı. Primer kanser ile ilgili yapılan tedaviye yanıt ve ikincil gelişen kanserin süresi arasında istatistiksel olarak anlamlı bir ilişki saptanmadı (p=0.36).Grupların tamamında sağ kalım süresi 24 ay senkron grupta, 12 ay metakron grupta belirlendi.SONUÇ: Primer hastalıktan sonra özellikle ilk 2.5 yıl içinde yakın takip ve hastalara sigara içiciliğinin bıraktırılmasının teşvik edilmesi önem taşımaktadır.

Anahtar Kelimeler

Akciğer kanseri, ikinci primer; senkron; metakron

Kaynakça

• Liu YY, Chen YM, Yen SH, Tsai CM, Perng RP. Multiple primary malignancies involving lung cancer-clinical characteristics and prognosis. Lung Cancer 2002;35:189-94
• Watanabe S, Kodama T, Shimosato Y, et al. Multiple primary cancers in 5,456 autopsy cases in the National Cancer Center of Japan. J Natl Cancer Inst 1984;72:1021-7
• Curtis RE, Boice JD Jr, Kleinerman RA, Flannery JT, Fraumeni JF Jr. Multiple primary cancers in Connecticut 1985;68:219-42 NCI Monogr
• Levi F, Randimbison L, Te VC, La Vecchia C. Second primary cancers in patients with lung carcinoma. Cancer 1999;86:186-90
• Holland JM, Arsanjani A, Liem BJ, Hoffelt SC, Cohen JI, Stevens KR Jr. Second malignancies in early stage laryngeal carcinoma patients treated with radiotherapy. Journal of Laryngology & Otology 2002;1163:190-3
• Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-47
• Hsu YB, Chang SY, Lan MC, Huang JL, Tai SK, Chu PY. Second primary malignancies in squamous cell carcinomas of the tongue and larynx: an analysis of incidence, pattern, and outcome. J Chin Med Assoc 2008;71:86-91
• Behrens C, Travis LB, Wistuba II, et al. Molecular changes in second primary lung and breast cancers after therapy for Hodgkin’s Disease. Cancer Epidemiology, 2000;9:1027-35 and Prevention
• Atienza JA, Dasanu CA. Incidence of second primary malignancies in patients with treated head and neck cancer: a comprehensive review of literature. Curr Med Res Opin 2012;28:1899-909
• Chuang SC, Scelo G, Tonita JM, et al. Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries. Int J Cancer 2008;123:2390
• Morris LG, Sikora AG, Patel SG, Hayes RB, Ganly I. Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J Clin Oncol 2011;29:739
• Lorigan P, Radford J, Howell A, Thatcher N. Lung cancer after treatment for Hodgkin's lymphoma: a systematic review. Lancet Oncol 2005;6:773
• Kaufman EL, Jacobson JS, Hershman DL, Desai M, Neugut AI. Effect of breast cancer radiotherapy and cigarette smoking on risk of second primary lung cancer. Journal of Clinical Oncology 2008;26:392-8
• Swerdlow AJ, Douglas AJ, Hudson GV, Hudson BV, Bennett MH, MacLennan KA. Risk of second primary cancers after Hodgkin's disease by type of treatment: analysis of 2846 patients in the British National 1992;304:1137 Investigation. BMJ
• Travis LB, Fosså SD, Schonfeld SJ, et al. Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 2005;97:1354
• Nandy N, Dasanu CA. Incidence of second primary malignancies in patients with esophageal cancer: a comprehensive review. Curr Med Res Opin 2013;29:1055-65
• Geurts TW, Nederlof PM, van den Brekel MW, et al. Pulmonary squamous cell carcinoma following head and neck squamous cell carcinoma: Metastasis or second 2005;11:6608-14 Cancer Research
• Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium. Cancer 1953;6:963-8
• Carey T. Field cancerization: are multiple primaries monoclonal or polyclonal? Ann Med 1996;28:183-8
• Parsons A, Daley A, Begh R, Aveyard P. Influence of smoking cessation after diagnosis of early stage lung cancer on prognosis: systematic review of observational studies with meta- analysis. BMJ 2010;340:b5569
• Li X, Hemminki K. Familial and second lung cancers: a nation- wide epidemiologic study from Sweden. Lung Cancer 2003;39:255-63
• Tan L, Greener CC, Seikaly H, Rassekh CH, Calhoun KH. Role of screening chest computed tomography in patients with advanced head and neck cancer.
• Otolaryngology 1999;120:689-92