Effects of Diazepam/Propofol and Diazepam/Remifentanil Induction Protocols on the Coagulation in Dogs

Yıl 2018, Cilt: 44 Sayı: 3, 122 - 127, 02.09.2018

Didar Aydın Kaya Özlem Güzel Erdal Matur Emine Esma Çerkez Simge Uğur Ezgi Ergen Dilek Olğun Erdikmen

Öz

DOI: 10.26650/actavet.2019.434600

Studying the effect of general anaesthesia on
blood parameters is extremely important both in terms of patient safety and
determining protocol suitability for the patient. There is no study on the
assessment of the effects of Diazepam/Propofol and Diazepam/Remifentanil
combination administered to dogs on clotting time, thrombin time (TT),
prothrombin time (PT), active partial thromboplastin time (aPTT) and buccal
mucosa bleeding time (BMBT). The purpose of the study presented is to
investigate the effects of Diazepam/Propofol and Diazepam/Remifentanil
combinations on coagulation parameters in dogs aged 5 years and older,
requiring surgery for various reasons. Prior to anaesthesia (T0), it was found
that there was no difference between the two groups in terms of PT, TT, aPTT
and BMBT (p=0.426 p=0.091, p=0.166, p=0.686, p=0.209, respectively). Following
anaesthesia (T1), it was found that the buccal mucosal bleeding time in dogs in
the Diazepam/Remifentanil group had a tendency to be shorter (p=0.084) than
those in the Diazepam/Propofol group. Also, PT in the Diazepam/Remifentanil
group was longer (p=0.031) compared to the Diazepam/Propofol group. No
significant difference was found between the groups with respect to clotting
time, TT or aPTT (p=0.191, p=0.467, p=0.972). While it is stated that neuroleptanalgesia
produces reliable anaesthesia induction in unwell patients, based on the data
obtained at the end of the study, it was determined that Diazepam/Propofol
combination is more reliable in the anaesthesia of patients requiring surgical
intervention.

Anahtar Kelimeler

Coagulation, diazepam, dog, remifentanil, propofol

Kaynakça

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