Kök Kanallarından Turuncu-Kahverengi Çökeltiyi Uzaklaştırmada Askorbik Asitin Etkinliği

Öz

Amaç: Bu çalışmanın amacı, kök kanal tedavisi sırasında sodyum hipoklorit ve klorheksidin solüsyonlarının etkileşimi sonucu oluşan turuncu-kahverengi para kloroanilin çökeltisinin (PKA) uzaklaştırılmasında askorbik asitin (AA) etkisini belirlemektir. Gereç ve Yöntem: PKA, laboratuvar koşullarında cam tüplerde 1.25 mL %2.5'lik sodyum hipoklorit ve 1.25 mL %2'lik klorheksidin çözeltileri karıştırılarak elde edildi. %5-30 arasında değişen farklı konsantrasyonlarda AA çözeltileri hazırlandı ve bu çözeltilerin kök kanalındaki PKA çözünürlüğü üzerindeki etkisi gravimetrik yöntemle belirlendi. Ayrıca, belirli mol oranlarında AA, gliserin ve deiyonize suyun (AA: Gli: H2O) 70 °C'de 1 saat karıştırılması ve sürenin sonunda oda sıcaklığına soğutulmasıyla derin ötektik bir çözücü sistemi (DÖÇ) elde edildi; bu sistemin AA çözeltisine göre daha etkili bir çözücü sistemi olduğu düşünüldü. DES'in PCA çözünürlüğü üzerindeki performansı aynı yöntem kullanılarak değerlendirildi. Bulgular: 25 °C'de sabit hacimde sodyum hipoklorit ve klorheksidin ile hazırlanan PKA'ya belirli hacimde serum fizyolojik uygulanarak hazırlanan kontrol grubunda, PKA'nın yaklaşık %27 oranında çözündüğü belirlendi. Aynı şekilde hazırlanan PKA'ya belirli hacimde AA uygulandığında, AA konsantrasyonundaki artışla bu oranın yaklaşık %55'e çıktığı belirlendi. Ayrıca, belirli hacimde DÖÇ uygulanan PKA'da %80'in üzerinde bir çözünürlük elde edildi. Sonuç: Kanal içerisinde oluşan PKA’nın uzaklaştırılmasında irrigasyon çözücüsü olarak yüksek konsantrasyonlu AA solüsyonunun kullanılabileceği, ayrıca DÖÇ sisteminin AA’ya kıyasla PKA’nın çözündürülmesinde daha etkili bir çözücü olma potansiyeline sahip olduğu bulunmuştur.

Anahtar Kelimeler

• Klorheksidin
• Sodyum hipoklorit
• Askorbik asit
• Kök kanal irrigasyonu
• Çözelti

Effectiveness of Ascorbic Acid in Eliminating Orange-Brown Precipitate from Root Canals

Öz

Objectives: To determine the effect of ascorbic acid (AA) on the removal of orange-brown precipitate (PCA) formed by the interaction of sodium hypochlorite (SH) and chlorhexidine (CHX) during root canal treatment. Materials and Method: PCA was obtained by mixing 1.25 mL of 2.5% SH and 1.25 mL of 2% CHX in glass tubes. Different concentrations of AA ranging from 5-30% were prepared and the effect of these solutions on PCA solubility was determined by gravimetric method. In addition, a deep eutectic solvent system (DES) was obtained by mixing certain mole ratios of AA, glycerin and deionized water at 70 °C for 1 h and cooling to room temperature at the end of the time. The performance of DES on the solubility of PCA was evaluated using the same method. Results: In control group prepared with a certain volume of physiological saline applied to PCA at constant volume at 25 °C, it was determined that PCA dissolved approximately 27%. When a certain volume of AA was applied to the PCA the same way, it was determined that this rate increased to approximately 55% with the increase in the concentration of AA. In addition, a solubility of over 80% was achieved in PCA to which a certain volume of DES was applied. Conclusion: High concentrations of AA can be used as an irrigating solvent for the removal of PCA and it was also found that DES system has the potential to be a more effective solvent for PCA solubilization compared to AA.

Anahtar Kelimeler

• Chlorhexidine
• Sodium hypochlorite
• Root canal irrigation
• Precipitate
• Ascorbic acid

Kaynakça

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