Öz

Background: Proliferative verrucous leukoplakia (PVL) is the rarest and stubborn subtype of oral leukoplakia (OL). The origin of PVL is still unknown and because the possible risk factors of OL are not in complete accordance with PVL, diagnosing the disease is very hard. PVL also needs special attention because of the high progression rate of squamous cell carcinoma and verrucous carcinoma. Case Report: A 54 year old female patient was admitted to our department with the complaint of painless white lesions in anterior region of the floor of the mouth. In the light of the clinical and radiological findings, with the initial OL diagnosis, lesion was excised using electrocautery as a whole under local anesthesia and sent for histopathological examination. Final diagnosis was “Proliferative Verrucous Hyperplasia”. After 60 months of follow-up, there was no recurrence. Conclusion and Clinical Relevance: Since PVL has high progression rate for malign lesions and high relapse rates, it is important to detect the disease at early stages, and long term follow-up after surgical excision is needed

Anahtar Kelimeler

• lökoplaki, proliferative verrüköz lökoplaki, premalign lezyonlar, oral kanserler, verrüköz hiperplazi

PROLIFERATIVE VERRUCOUS LEUKOPLAKIA: FIVE YEARS FOLLOW-UP

Öz

Background: Proliferative verrucous leukoplakia (PVL) is the rarest and stubborn subtype of oral leukoplakia (OL). The origin of PVL is still unknown and because the possible risk factors of OL are not in complete accordance with PVL, diagnosing the disease is very hard. PVL also needs special attention because of the high progression rate of squamous cell carcinoma and verrucous carcinoma. Case Report: A 54 year old female patient was admitted to our department with the complaint of painless white lesions in anterior region of the floor of the mouth. In the light of the clinical and radiological findings, with the initial OL diagnosis, lesion was excised using electrocautery as a whole under local anesthesia and sent for histopathological examination. Final diagnosis was “Proliferative Verrucous Hyperplasia”. After 60 months of follow-up, there was no recurrence. Conclusion and Clinical Relevance: Since PVL has high progression rate for malign lesions and high relapse rates, it is important to detect the disease at early stages, and long term follow-up after surgical excision is needed

Anahtar Kelimeler

• leukoplakia, proliferative verrucous leukoplakia, potentially malignant disorders, oral cancer, verrucous hyperplasia

Kaynakça

1. Lodi G, Sardella A, Bez C, Demarosi F, Carrassi A. Interventions for treating oral leukoplakia. The Cochrane database of systematic reviews. 2006(4):CD001829.
2. Kumar A, Cascarini L, McCaul JA, Kerawala CJ, Coombes D, Godden D, et al. How should we manage oral leukoplakia? The British journal of oral & maxillofacial surgery. 2013;51(5):377- 83.
3. Hansen LS, Olson JA, Silverman S, Jr. Proliferative verrucous leukoplakia. A long- term study of thirty patients. Oral surgery, oral medicine, and oral pathology. 1985;60(3):285- 98.
4. Abadie WM, Partington EJ, Fowler CB, Schmalbach CE. Optimal Management of Proliferative Verrucous Leukoplakia: A Systematic Review of the Literature. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2015;153(4):504-11.
5. Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, El-Naggar AK. Proliferative verrucous leukoplakia: recognition and differentiation from conventional leukoplakia and mimics. Head & neck. 2014;36(11):1662-8.
6. Cerero-Lapiedra R, Balade-Martinez D, Moreno-Lopez LA, Esparza-Gomez G, Bagan JV. Proliferative verrucous leukoplakia: a proposal for diagnostic criteria. Medicina oral, patologia oral y cirugia bucal. 2010;15(6):e839- 45.
7. Batsakis JG, Suarez P, el-Naggar AK. Proliferative verrucous leukoplakia and its related lesions. Oral oncology. 1999;35(4):354- 9.
8. Pentenero M, Meleti M, Vescovi P, Gandolfo S. Oral proliferative verrucous leucoplakia: are there particular features for such an ambiguous entity? A systematic review. The British journal of dermatology. 2014;170(5):1039-47.

9. Silverman S, Jr., Gorsky M. Epidemiologic and demographic update in oral cancer: California and national data--1973 to 1985. Journal of the American Dental Association. 1990;120(5):495- 9.
10. Gandolfo S, Castellani R, Pentenero M. Proliferative verrucous leukoplakia: a potentially malignant disorder involving periodontal sites. Journal of periodontology. 2009;80(2):274-81.
11. Silverman S, Jr., Gorsky M, Lozada F. Oral leukoplakia and malignant transformation.
12. A follow-up study of 257 patients. Cancer. 1984;53(3):563-8.