Evaluation of infrared thermography findings in postoperative follow-up in dogs with pyometra

Öz

In this study, the usability of infrared thermography (IRT) applications in the postoperative follow-up after the sterilization operation was investigated in dogs with pyometra. The study was carried out on healthy animals (Group 2, n=7) diagnosed as pyometra (Group 1, n=7) and undergone elective ovariohysterectomy, consisting of 14 female dogs. Serum CRP levels were measured from the patients before the operation and on the 1st, 4, and 7th days postoperatively. Thermographic images from the eye and incision area were recorded, and the results were analyzed statistically. There were no intraoperative and postoperative complications in both study groups, and all dogs in Group 1 recovered uneventfully. Serum CRP levels were higher at 0, 4th, and 7th days in Group 1 (P<0.05), while they were at a peak level on the 1st day (P>0.05) in both groups, a decrease was observed on the 4th and 7th days (P<0.05). Postoperative CRP levels in all animals tended to decrease on the 4thand 7thdays. There was no statistical difference between and within the eye and abdominal thermographic examinations (P>0.05). While serum CRP values reached the maximum level on the 1st day after surgery in the healthy and patient groups, it was seen as a milder increase due to the inflammatory reaction in the pyometra group. Due to the uncomplicated completion of the study, CRP values tended to decrease on the 4thday, and no significant difference was observed in the thermographic images. However, it is not reflected in the statistical data; in the pyometra group, the eye on the 1st and 4th days. The abdominal temperature remained higher than the control group on all other days. It is thought that the use of thermography, which is a non-invasive and practical application, in addition to serum CRP measurement after ovariohysterectomy, in similar studies to be applied in larger populations in the future, will help determine the prognosis.

Anahtar Kelimeler

• Dog
• postoperative monitoring
• pyometra
• thermography

Destekleyen Kurum

Aydın Adnan Menderes University Scientific Research Projects Unit

Proje Numarası

VTF-20014

Kaynakça

1. Albert, R., Reese, S., Nolff, M. C., & Meyer-Lindenberg, A. (2019). Evaluation of Systemic Effects of Negative Pressure Wound Therapy in Open Wound Treatment in Dogs. VCOT Open, 02(02), e1–e8. https://doi.org/10.1055/s-0039-1693007
2. Armstrong, D. G., Lipsky, B. A., Polis, A. B., & Abramson, M. A. (2006). Does dermal thermometry predict clinical outcome in diabetic foot infection? Analysis of data from the SIDESTEP* trial. International Wound Journal, 3(4), 302–307. https://doi.org/10.1111/j.1742-481X.2006.00269.x
3. Black, S., Kushner, I., & Samols, D. (2004). C-reactive protein. In Journal of Biological Chemistry (Vol. 279, Issue 47, pp. 48487–48490). https://doi.org/10.1074/jbc.R400025200
4. Casas-Alvarado, A., Mota-Rojas, D., Hernández-Ávalos, I., Mora-Medina, P., Olmos-Hernández, A., Verduzco-Mendoza, A., Reyes-Sotelo, B., & Martínez-Burnes, J. (2020). Advances in infrared thermography: Surgical aspects, vascular changes, and pain monitoring in veterinary medicine. In Journal of Thermal Biology (Vol. 92, p. 102664). https://doi.org/10.1016/j.jtherbio.2020.102664
5. Childs, C., Siraj, M. R., Fair, F. J., Selvan, A. N., Soltani, H., Wilmott, J., & Farrell, T. (2016). Thermal territories of the abdomen after caesarean section birth: Infrared thermography and analysis http://www.magonlinelibrary.com/doi/pdf/10.12968/jowc.2016.25.9.499. Journal of Wound Care, 25(9), 499–512. https://doi.org/10.12968/jowc.2016.25.9.499
6. Childs, C., & Soltani, H. (2020). Abdominal cutaneous thermography and perfusion mapping after caesarean section: A scoping review. In International Journal of Environmental Research and Public Health (Vol. 17, Issue 22, pp. 1–22). https://doi.org/10.3390/ijerph17228693
7. Childs, C., Wright, N., Willmott, J., Davies, M., Kilner, K., Ousey, K., Soltani, H., Madhuvrata, P., & Stephenson, J. (2019). The surgical wound in infrared: thermographic profiles and early stage test-accuracy to predict surgical site infection in obese women during the first 30 days after caesarean section. Antimicrobial Resistance & Infection Control, 8(1), 7. https://doi.org/10.1186/s13756-018-0461-7
8. Christensen, M. B., Eriksen, T., & Kjelgaard-Hansen, M. (2015). C-reactive protein: Quantitative marker of surgical trauma and post-surgical complications in dogs: A systematic review. In Acta Veterinaria Scandinavica (Vol. 57, Issue 1, p. 71). https://doi.org/10.1186/s13028-015-0164-5

9. Cilulko, J., Janiszewski, P., Bogdaszewski, M., & Szczygielska, E. (2013). Infrared thermal imaging in studies of wild animals. In European Journal of Wildlife Research (Vol. 59, Issue 1, pp. 17–23). https://doi.org/10.1007/s10344-012-0688-1
10. Colak, A., Polat, B., Okumus, Z., Kaya, M., Yanmaz, L. E., & Hayirli, A. (2008). Short communication: Early detection of mastitis using infrared thermography in dairy cows. Journal of Dairy Science, 91(11), 4244–4248. https://doi.org/10.3168/jds.2008-1258
11. Dabrowski, R., Kostro, K., Lisiecka, U., Szczubiał, M., & Krakowski, L. (2009). Usefulness of C-reactive protein, serum amyloid A component, and haptoglobin determinations in bitches with pyometra for monitoring early post-ovariohysterectomy complications. Theriogenology, 72(4), 471–476. https://doi.org/10.1016/j.theriogenology.2009.03.017
12. Dabrowski, R., Wawron, W., & Kostro, K. (2007). Changes in CRP, SAA and haptoglobin produced in response to ovariohysterectomy in healthy bitches and those with pyometra. Theriogenology, 67(2), 321–327. https://doi.org/10.1016/j.theriogenology.2006.07.019
13. Eckersall, P. D., & Bell, R. (2010). Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. In Veterinary Journal (Vol. 185, Issue 1, pp. 23–27). https://doi.org/10.1016/j.tvjl.2010.04.009
14. Franco, N. H., Gerós, A., Oliveira, L., Olsson, I. A. S., & Aguiar, P. (2019). ThermoLabAnimal – A high-throughput analysis software for non-invasive thermal assessment of laboratory mice. Physiology and Behavior, 207, 113–121. https://doi.org/10.1016/j.physbeh.2019.05.004
15. Fransson, B., & Ragle, C. (2003). Suture biomechanics View project Laparoscopic small intestine exploration in the standing horse View project. Compendium on Continuing Education for the Practising Veterinarian, 25, 602–610. www.VetLearn.com
16. Freeman, L. J., Rahmani, E. Y., Sherman, S., Chiorean, M. v., Selzer, D. J., Constable, P. D., & Snyder, P. W. (2009). Oophorectomy by natural orifice transluminal endoscopic surgery: feasibility study in dogs. Gastrointestinal Endoscopy, 69(7), 1321–1332. https://doi.org/10.1016/j.gie.2008.10.028
17. Gumpert Herlofson, E. (2017). The use of thermography in evaluation of surgical wounds in smalla animal practice.
18. Howe, L. M. (2006). Surgical methods of contraception and sterilization. Theriogenology, 66(3 SPEC. ISS.), 500–509. https://doi.org/10.1016/j.theriogenology.2006.04.005
19. Hummelink, S., Kruit, A. S., van Vlaenderen, A. R. W., Schreinemachers, M. J. M., Steenbergen, W., & Ulrich, D. J. O. (2020). Post-operative monitoring of free flaps using a low-cost thermal camera: a pilot study. European Journal of Plastic Surgery, 43(5), 589–596. https://doi.org/10.1007/s00238-020-01642-y
20. Jitpean, S., Holst, B. S., Höglund, O. v., Pettersson, A., Olsson, U., Strage, E., Södersten, F., & Hagman, R. (2014). Serum insulin-like growth factor-I, iron, C-reactive protein, and serum amyloid A for prediction of outcome in dogs with pyometra. Theriogenology, 82(1), 43–48. https://doi.org/10.1016/j.theriogenology.2014.02.014
21. Kraemer, R., Lorenzen, J., Knobloch, K., Papst, S., Kabbani, M., Koennecker, S., & Vogt, P. M. (2011). Free flap microcirculatory monitoring correlates to free flap temperature assessment. Journal of Plastic, Reconstructive and Aesthetic Surgery, 64(10), 1353–1358. https://doi.org/10.1016/j.bjps.2011.04.030
22. Liao, P. Y., Chang, S. C., Chen, K. S., & Wang, H. C. (2014). Decreased postoperative C-reactive protein production in dogs with pyometra through the use of low-dose ketamine. Journal of Veterinary Emergency and Critical Care, 24(3), 286–290. https://doi.org/10.1111/vec.12178
23. Löfqvist, K., Kjelgaard-Hansen, M., & Nielsen, M. B. M. (2018). Usefulness of C-reactive protein and serum amyloid A in early detection of postoperative infectious complications to tibial plateau leveling osteotomy in dogs. Acta Veterinaria Scandinavica, 60(1), 30. https://doi.org/10.1186/s13028-018-0385-5
24. Martínez-Subiela, S., Caldin, M., Parra, M. D., Ottolini, N., Bertolini, G., Bernal, L. J., García-Martinez, J. D., & Cerón, J. J. (2011). Canine C-reactive protein measurements in cerebrospinal fluid by a time-resolved immunofluorimetric assay. Journal of Veterinary Diagnostic Investigation, 23(1), 63–67. https://doi.org/10.1177/104063871102300109
25. Martins, R. F. S., do Prado Paim, T., de Abreu Cardoso, C., Stéfano Lima Dallago, B., de Melo, C. B., Louvandini, H., & McManus, C. (2013). Mastitis detection in sheep by infrared thermography. Research in Veterinary Science, 94(3), 722–724. https://doi.org/10.1016/j.rvsc.2012.10.021
26. Mathon, D. H., Palierne, S., Meynaud-Collard, P., Layssol-Lamour, C., Dulaurent- Ferrieres, A., Colson, A., Lacroix, M., Bousquet-Melou, A., Delverdier, M., & Autefage, A. (2011). Laparoscopic-Assisted Colopexy and Sterilization in Male Dogs: Short-Term Results and Physiologic Consequences. Veterinary Surgery, 40(4), 500–508. https://doi.org/10.1111/j.1532-950X.2011.00835.x
27. Nevill, B., Leisewitz, A., Goddard, A., & Thompson, P. (2010). An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy. Journal of the South African Veterinary Association, 81(1), 22–26. https://doi.org/10.4102/jsava.v81i1.90
28. Petersen, H. H., Nielsen, J. P., & Heegaard, P. M. H. (2004). Application of acute phase protein measurements in veterinary clinical chemistry. In Veterinary Research (Vol. 35, Issue 2, pp. 163–187). https://doi.org/10.1051/vetres:2004002
29. Saunders, A. B., Hanzlicek, A. S., Martinez, E. A., Stickney, M. J., Steiner, J. M., Suchodolski, J. S., & Fosgate, G. T. (2009). Assessment of cardiac troponin i and C-reactive protein concentrations associated with anesthetic protocols using sevoflurane or a combination of fentanyl, midazolam, and sevoflurane in dogs. Veterinary Anaesthesia and Analgesia, 36(5), 449–456. https://doi.org/10.1111/j.1467-2995.2009.00483.x
30. Schwartzkopf-Genswein, K. S., & Stookey, J. M. (1997). The use of infrared thermography to assess inflammation associated with hot-iron and freeze branding in cattle. Canadian Journal of Animal Science, 77(4), 577–583. https://doi.org/10.4141/A97-019
31. Serin, G., & Ulutas, P. A. (2010). Measurement of serum acute phase proteins to monitor postoperative recovery in anoestrous bitches after ovariohysterectomy. Veterinary Record, 166(1), 20–22. https://doi.org/10.1136/vr.b5585
32. Siah, C. J. R., Childs, C., Chia, C. K., & Cheng, K. F. K. (2019). An observational study of temperature and thermal images of surgical wounds for detecting delayed wound healing within four days after surgery. Journal of Clinical Nursing, 28(11–12), 2285–2295. https://doi.org/10.1111/jocn.14832
33. Singh, D., Kashav, R., Magoon, R., Kohli, J. K., Kaur, M., Gupta, A., & Gupta, V. (2020). Evaluation of Low-Dose Ketamine on Inflammatory Biomarker Profile Following Off-Pump Coronary Artery Bypass Grafting. Journal of Cardiac Critical Care TSS, 04(01), 33–39. https://doi.org/10.1055/s-0040-1713299
34. Slavov, E., Mircheva Georgieva, T., Andonova, M., Urumova, V., Girginov, D., & Dzhelebov, P. (2011). Blood C reactive protein (CRP) and fibrinogen concentrations during staphylococcal experimental infection in obese dogs. In Revue de Medecine Veterinaire (Vol. 162, Issue 12, pp. 599–603).
35. Stewart, M., Webster, J. R., Verkerk, G. A., Schaefer, A. L., Colyn, J. J., & Stafford, K. J. (2007). Non-invasive measurement of stress in dairy cows using infrared thermography. Physiology and Behavior, 92(3), 520–525. https://doi.org/10.1016/j.physbeh.2007.04.034
36. Vollmer, M., & Möllmann, K. P. (2017). Infrared thermal imaging: Fundamentals, research and applications. In Infrared thermal imaging: Fundamentals, research and applications (2nd ed.). https://doi.org/10.1002/9783527693306
37. Wiig, H., & Swartz, M. A. (2012). Interstitial fluid and lymph formation and transport: Physiological regulation and roles in inflammation and cancer. In Physiological Reviews (Vol. 92, Issue 3, pp. 1005–1060). https://doi.org/10.1152/physrev.00037.2011
38. Yang, C., Li, G., Zhang, X., & Gu, X. (2018). Udder skin surface temperature variation pre- and post- milking in dairy cows as determined by infrared thermography. Journal of Dairy Research, 85(2), 201–203. https://doi.org/10.1017/S0022029918000213
39. Zhang, S. X., Wang, H. bin, Zhang, J. T., Zhang, N., & Pan, L. (2013). Laparoscopic colopexy in dogs. Journal of Veterinary Medical Science, 75(9), 1161–1166. https://doi.org/10.1292/jvms.12-0538