Evaluation of radiation attenuation properties of some cancer drugs

Öz

The present study was conducted to estimate the radiation attenuation parameters of six different antineoplastic drugs used in the cure of cancer diseases. The effective atomic number and electron density of anastrozole, epirubicin, gemcitabine, ifosfamide, methotrexate and paclitaxel were computed theoretically in the energy region of 1keV to 100 GeV. The energy absorption buildup factors (EABF) and exposure buildup factors (EBF) for these chemotherapy drugs were also examined by applying GP-fitting method. The variation of EABF and EBF values with photon energy and penetration depth were presented graphically and discussed. The results obtain from this study pointed out that buildup factors rely on the chemical combination of the drugs, incident photon energy and penetration thickness. It was observed that ifosfamide had a significantly better radiation absorption effect compared to other drugs. The data obtained from this study are expected to be useful in the fields of radiation biology, radiation dosimetry and radiotherapy.

Anahtar Kelimeler

• Cancer drugs
• Radiation
• Effective atomic number
• Effective electron density
• Buildup factor

Kaynakça

1. [1] Oto, B., Oto, G., Madak, Z., Kavaz, E., The interaction of gamma radiation with drugs used in cholinergic medications, Journal of Radiation Biology, 96(2), 236-244, 2020.
2. [2] Yorgun,N.Y., Kavaz, E., Gamma photon protection properties of some cancer drugs for medical applications. Results in Physics, 13 (102150), 1-6, 2019.
3. [3] Veranda, E., Tavares, D., Radioprotection mechanisms and radioprotective agents, including honeybee venom, Journal of Venomous Animals and Toxins, 4(1), 5-20, 1988.
4. [4] Sayyed, M.I., Kaky, K.M., Şakar, E., Akbaba, U., Taki, M.M., Agar, O., Gamma radiation shielding investigations for selected germanate glasses, Journal of Non-Crystalline Solids, 512, 33–40, 2019.
5. [5] Manohara, S.R., Hanagotimath. S.M., Gerward, L. Energy absorption buildup factors of human organs and tissues at energies and penetration depths relevant for radiotherapy and diagnostics, Journal of Applied Clinical Medical Physics, 12, 3557–3566, 2011.
6. [6] Singh, S.P., Singh, T., Kaur, P., Variation of energy absorption buildup factors with incident photon energy and penetration depth for some commonly used solvents, Annals of Nuclear Energy, 35, 1093–1097, 2008.
7. [7] Harima, Y., Sakamoto, Y., Tanaka, S., Kawai, M. Validity of the geometric progression formula in approximating gamma ray buildup factors, Nuclear Science and Engineering, 94, 24-35, 1986.
8. [8] Shimizu, A., Calculations of gamma ray buildup factors up to depths of 100 mfp by the method of invariant embedding, (I) analysis of accuracy and comparison with other data, Journal of Nuclear Science and Technology, 39, 477-486, 2002.

9. [9] Suteau, C., Chiron, M., An iterative method for calculating gamma ray buildup factors in multi-layer shields, Radiation Protection Dosimetry, 116, 489-492, 2005.
10. [10] Sardari, D., Saudi, S., Tajik, M., Evaluation of gamma ray buildup factor data in water with MCNP4C code, Annals of Nuclear Energy, 38(23), 628-631, 2011.
11. [11] Harima Y., An approximation of gamma ray buildup factors by modified geometrical progression, Nuclear Science and Engineering, 83, 299-309, 1983.
12. [12] Singh, V.P., Badiger, N.M., Investigation on radiation shielding parameters of ordinary, heavy and super heavy concretes, Nuclear Technology and Radiation Protection 29, 149–156, 2014.
13. [13] Şakar, E., Büyükyıldız, M., Alım, B., Şakar, B.C., Kurudirek, M., Leaded brass alloys for gamma-ray shielding applications, Radiation Physics and Chemistry, 159, 64–69, 2019.
14. [14] Şakar, E., Determination of photon-shielding features and build-up factors of nickel–silver alloys, Radiation Physics and Chemistry, 172, 108778, 2021.
15. [15] Kaur, P., Singh, D., Singh, T., Gamma ray shielding and sensing application of some rare earth doped lead-alumino-phosphate glasses, Radiation Physics and Chemistry, 144, 336–343, 2018.
16. [16] Rammah, Y.S., Özpolat, Ö.F., Alım, B., Şakar, E., El-Mallawany, R., El-Agawany F.I., Assessment of gamma-ray attenuation features for La+3 co-doped zinc borotellurite glasses, Radiation Physics and Chemistry, 176, 109069, 2020.
17. [17] Sayyed, M., AlZaatreh, M., Matori, K., Sidek, H., Zaid, M., Comprehensive study on estimation of gamma ray exposure buildup factors for smart polymers as a potent application in nuclear industries, Results in Physics, 9, 585–592, 2018.
18. [18] Sharaf, J.M., Saleh, H., Gamma-ray energy buildup factor calculations and shielding effects of some Jordanian building structures, Radiation Physics and Chemistry, 110, 87–95, 2015.
19. [19] Manjunatha, H.C., Rudraswamy, B., Computation of exposure build-up factors in teeth, Radiation Physics and Chemistry, 80 (1), 14–21, 2011.
20. [20] Kurudirek, M., Topcuoglu, S., Investigation of human teeth with respect to the photon interaction, energy absorption and buildup factor, Nuclear Instruments and Methods in Physics Research B, 269, 1071–1081, 2011.
21. [21]. Yilmaz, D., Gedik, Z., Tugrak, M., Gul, H.I., Energy absorption buildup factors of some potential bioactive compounds in the energy region 0.015-15 MeV, Spectroscopy Letters, 50(6), 301-306, 2017.
22. [22] Bursalıoglu, E., Balkan, B., Kavanoz, H.B., Okutan, M., Icelli, O., Yalcın, Z., Energy absorption and exposure buildup factors of essential amino acids, Biomed Research International, 359754, 2014.
23. [23] Turhan, M.F., Durak, R., Kaçal, M.R., Determination of Gamma Ray Buildup Factors of Some Enzyme Inhibitors, International Journal of Scientific and Engineering Research, 10 (9), 8-13, 2019.
24. [24] Manohara, S.R., Hanagodimath, S.M., Gerward, L., Energy absorption buildup factors for thermoluminescent dosimetic materials and their tissue equivalent, Radiation Physics and Chemistry, 79, 575–582, 2010.
25. [25] Kummerer, K., Haiss, A., Schuster, A., Hein, A., Ebert, I., Antineoplastic compounds in the environment-substances of special concern, Environmental Science and Pollution Research, 23(15), 14791-14804, 2016.
26. [26] Yeo, W., Johnson, P.J., Radiation-recall skin disorders associated with the use of antineoplastic drugs, Pathogenesis, prevalence, and management, American Journal of Clinical Dermatology, 1, 113–116, 2000.
27. [27] Wiseman, L.R., Adkins J.C., Anastrozole: a review of its use in the management of postmenopausal women with advanced breast cancer, Drugs Aging, 13, 321-32, 1998.
28. [28] Coukell, A.J., Faulds, D., Epirubicin: An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of breast cancer, Drugs, 53, 453-482, 1997.
29. [29] Mini, E., Nobili, S., Caciagli, B., Landini, I., Mazzei, T., Cellular pharmacology of gemcitabine, Annals of Oncology, 17, 7–12, 2006.
30. [30] Dechant, K.L., Brogden, R.N., Pilkington, T., Faulds, D., Ifosfamide/mesna: A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer, Drugs 42, 428–467, 1991.
31. [31] Rowinsky, E.K., Donehower, R.C., Paclitaxel (taxol), The New England Journal of Medicine, 332, 1004 -1014, 1995.
32. [32] Sayyed M.I., Issa S.A., Auda S.H., Assessment of radio-protective properties of some anti-inflammatory drugs, Progress in Nuclear Energy, 100, 297–308, 2017.
33. [33] Kavaz, E., Ahmadishadbad, N., Özdemir, Y., Photon buildup factors of some chemotherapy drugs, Biomed Pharmacother, 69, 34–41, 2015.
34. [34] Akman, F., Kaçal, M.R., Investigation of radiation attenuation parameters of some drugs used in Chemotherapy in Wide Energy Region, Journal of Radiology and Oncology, 2, 047-052, 2018.
35. [35] Ekinci, N., Kavaz, E., Ozdemir, Y., A study of the energy absorption and exposure buildup factors of some anti-inflammatory drugs, Applied Radiation and Isotopes, 90, 265–273, 2014.
36. [36] Jackson, D.F., Hawkes, D.J., X-ray attenuation coefficients of elements and mixtures, Physics Reports, 70, 169–233, 1981.
37. [37] Alim, B., Şakar, E., Baltakesmez, A., Han, İ., Sayyed, M.I., Demir, L., Experimental investigation of radiation shielding performances of some important AISI-coded stainless steels: Part I, Radiation Physics and Chemistry, 160, 108455, 2020.
38. [38] Gerward, L., Guilbert, N.K., Jensen, B., Levring, H., WinXCom–a program for calculating X-ray attenuation coefficients, Radiation Physics and Chemistry, 71(3–4), 653–654, 2004.
39. [39] Şakar, E., Özpolat, O.F., Alım, B., Sayyed, M.I., Kurudirek, M., Phy-X/PSD: Development of a user friendly online software for calculation of parameters relevant to radiation shielding and dosimetry, Radiation Physics and Chemistry, 108496, 1-12, 2020.
40. [40] ANSI/ANS-6.4.3, Gamma ray attenuation coefficient and buildup factors for engineering materials, Illinois:American Nuclear Society, La Grange Park, 1991.
41. [41] Raut, S.D., Awasarmol, V.V., Shaikh, S.F., Ghule, B.G., Ekar, S.U., Mane, R.S., Pawar, P.P., Study of gamma ray energy absorption and exposure buildup factors for ferrites by geometric progression fitting method, Radiation Effects and Defects in Solids, 173 (3-4), 429-438, 2018.
42. [42] Kavaz, E., Perisanoglu, U., Ekinci, N., Ozdemir, Y., Determination of energy absorption and exposure buildup factors by using GP fitting approximation for radioprotective agents, International Journal of Radiation Biology, 92(7); 380–387, 201