The Protective Effects of Silymarin on D-Galactosamine/Tumor Necrosis FactorAlpha-Induced Oxidative Stress and Lung Injury in Mice

Yıl 2018, Cilt: 8 Sayı: 1, 42 - 52, 30.06.2018

Mustafa Cengiz

https://doi.org/10.37094/adyujsci.405690

Cited By: 1

Öz

Silymarin (Sm) is known for its anti-oxidative, anti-inflammatory, and antimitotic
activities against a broad range of cancers, such as prostate, colon, ovarian, skin
and lung cancer. This study targets to determine the protective effects of Sm on lung
damage in the mice exposed to D-galactosamine (D-GaIN)/tumour necrosis factor alpha
(TNF-α). For this purpose, three groups of Balb/c mice were used. The study groups
were given saline (0.5 mL), D-GalN/TNF-a, and D-GaIN/TNF-α plus Sm, respectively.
Our biochemistry, apoptotic markers and light microscopic findings offer that Sm can
noticeably diminish D-GaIN/TNFα-induced pulmonary toxicity. In conclusion, Sm
improves degenerative alterations in injured lung owing to D-GalN/TNF-a. This caring
effect might be thanks to the capability of Sm to keep oxidant–antioxidant stability. 

Anahtar Kelimeler

D-galactosamine, Silymarin, Tumour necrosis factor alpha, Apoptotic marker, Lung damage

D-Galaktozamin/Tümör Nekroz Faktör Alfa Nedenli Oksidatif Stress ve Akciğer Hasarı Üzerine Silmarinin Koruyucu Etkileri

Öz

Silymarin (Sm), prostat, kolon, yumurtalık, deri ve akciğer kanseri gibi çok çeşitli kanserlerin tedavisinde kullanılan anti-oksidatif, anti-inflamatuar ve anti-mitotik aktiviteleri ile bilinen bir bileşiktir. Bu çalışma, D-galaktosamin (D-GaIN) / tümör nekrozis faktör alfa (TNF-α) nedenli oksidatif stress ve akciğer hasarı üzerinde Sm’nin koruyucu etkilerini belirlemeyi amaçlamaktadır. Bu amaçla 21 adet Balb / c cinsi erek fare kullanıldı (n=7). Çalışma gruplarına sırasıyla serum fizyolojik (0.5 mL), D-GalN / TNF-a ve D-GaIN / TNF-α artı Sm verildi. Biyokimyasal, histopatolojik ve apoptotik bulgularımıza göre, Sm'nin D-GaIN / TNF-a nedenli pulmoner toksisiteyi ve oksidatif stressi belirgin olarak azaltabildiğini göstermektedir. Sonuç olarak, Sm, D-GalN / TNFa'ya bağlı akciğerde meydana gelen dejeneratif değişiklikleri olumlu yönde iyileştirdiği görülmüştür. Sm’nin bu etkisi, oksidan-antioksidan stabilitesini koruma özelliğinden dolayı olduğunu düşünmekteyiz.

Anahtar Kelimeler

D-galaktozamin, Simarin, Tümör nekroz faktör, Apoptotic marker, Akciğer hasarı

Kaynakça

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