Suda Çözünebilir Schiff Bazı Metal Komplekslerinin Sentezi ve Antikanser Aktivitesi

Yıl 2020, Cilt: 10 Sayı: 2, 441 - 454, 30.12.2020

Burcu Saygıdeğer Demir , İlyas Gönül , Gizem Gümüşgöz Çelik Seda İpekbayrak Yasemin Saygideger

https://doi.org/10.37094/adyujsci.738743

Öz

Bu çalışmada, 4-amino-3-hidroksinaftalin-1-sülfonik asit ve 2-hidroksi-3- metoksibenzaldehitten kondensasyon reaksiyonu ile S, O, N hetero atomları içeren suda çözünebilir bir Schiff Bazı elde edildi. Ek olarak, ligandın Cu (II), Zn (II) ve Ni (II) kompleksleri sentezlendi ve elementel analiz, manyetik duyarlılık ve FT-IR, H-NMR ve C-NMR gibi spektroskopik tekniklerle karakterize edildi. Ligandın ve üç metal kompleksinin A549 akciğer kanseri hücre hattında antikanser aktiviteleri değerlendirildi. L-Cu ve L-Zn olarak etiketlenmiş Bakır (II) ve Çinko (II) komplekslerinin IC50 değerleri sırasıyla 12 ve 80 μM olarak bulundu. L- Cu ve L-Zn komplekslerinin A549 hücrelerinde apoptozu indüklediği ve hücre göçünü inhibe ettiği görüldü. Ligand (L) ve Nikel (II) bileşiklerinin (L-Ni) A549 hücre proliferasyonu üzerinde herhangi bir etki göstermediği belirlendi.

Anahtar Kelimeler

Schiff bazı, Metal kompleksleri, Akciğer kanseri, Hücre kültürü

Synthesis and Anticancer Activities of Water Soluble Schiff Base Metal Complexes

Öz

In this study, we synthesized the water-soluble Schiff Base containing S, O, N heteroatoms by the condensation reaction from 4-amino-3-hydroxynaphthalene-1-sulfonic acid and 2- hydroxy-3-methoxybenzaldehyde. In addition, Cu (II), Zn (II) and Ni (II) complexes of the ligand were synthesized and characterized by elemental analysis, magnetic susceptibility and spectroscopic techniques such as FT-IR, H-NMR and C-NMR. The anticancer activities of ligand and its three metal complexes on A549 lung cancer cell lines were evaluated. Cell viability experiments revealed that Ligand (L) and nickel (II) complex (L-Ni) did not able to inhibit A549 cell proliferation while L-Cu and L-Zn had 12 and 80 μM of IC50 values respectively. These last two complexes also induced apoptosis and suppressed cell migration on A549 cells.

Anahtar Kelimeler

Schiff base, Metal complexes, Lung cancer, Cell culture

Kaynakça

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