A rare cause of cholestasis: Ampullary somatostatinoma

Öz

Somatostatinomas are rare neuroendocrine tumors. Gastrointestinal somatostatinomas are usually found in the pancreas but may also be seen in the duodenum. Duodenal somatostatinomas are especially localized in the periampullary region. Although they may occasionally lead to hormonal syndromes they are usually non-functional. In this report we present a case of ampullary somatostatinoma.

Anahtar Kelimeler

• Ampullary somatostatinoma

Nadir görülen bir kolestaz nedeni: Ampuller somatostatinoma

Öz

Somatostatinomalar, nadir görülen nöroendokrin tümörlerdir. Gastrointestinal sistem somatostatinomaları, çoğunlukla pankreasta olmakla birlikte nadiren duodenumda da görülebilirler. Duodenal somatostatinomalar da özellikle periampuller alanda lokalizedirler. Nadiren klinik hormonal sendromlara neden olabilmekle beraber çoğunluğu nonfonksiyoneldir. Bu yazıda bir ampuller somatostatinoma vakasını sunduk

Anahtar Kelimeler

• Ampuller somatostatinoma

Kaynakça

1. Hoffmann KK, Furukawa M, Jensen RT. Duodenal neuroen- docrine tumors: Classification, functional syndromes, diagno- sis and medical treatment. Best Pract Res Clin Gastroenterol 2005;19:675-97.
2. Kim JA, Choi WH, Kim CN, et al. Duodenal somatostatinoma: A case report and review. Korean J Intern Med 2011;26:103-7.
3. Deschamps L, Dokmak S, Guedj N, et al. Mixed endokrin so- matostatinoma of the ampulla of vater associated with a neuro- fibromatosis type 1: A case report and review of the literature. J Pancreas 2010;11:64-8.
4. Golovic R, Micev M, Grubor N, Radak V. Somatostatinoma of the Vater’s papilla in a patient with von Recklinghausen’s disease. Vo- jnosanit Pregl 2007;64:219-22.
5. Ferrante AMR, Frontera D, Doglietto GB, et al. Duodenal malignant somatostatinoma. HPB Surgery 1995;8:263-6.
6. Varikatt W, Yong JLC, Killingsworth MC. Somatostatinoma: colli- sion with neurofibroma and ultrastructural features. Histol Histopa- tol 2006;21:1171-80.
7. Guercioni G, Marmorale C, Siquini W, et al. Incidental small am- pullary somatostatinoma treated with ampullektomy 2 years after diagnosis. Dig Dis Sci 2006;51:1767-72.
8. Bettini R, Falconi M, Crippa S, et al. Ampullary somatostatinomas and jejunal gastrointestinal stromal tumor in a patient with Von Recklinghausen’s disease. World J Gastroenterol 2007;13:2761- 3.

9. Sakorafas GH, Giannopoulos GA, Parasi A, et al. Large somatosta- tin- producing endocrin carcinoma of the ampulla of vater in as- sociation with GIST in a patient with von Recklinghausen’s disease. Case report and review of the literature. JOP 2008;9:633-9.
10. Kainuma O, Ito Y, Taniquchi T, et al. Ampullary somatostatinoma in a patient with von Recklinghausen’s disease. J Gastroenterol 1996;31:460-4.
11. Relles D, Baek J, Witkiewicz A, Yeo CJ. Periampullary and duodenal neoplasm in neurofibromatosis type 1: Two cases and an updated 20-year review of the literature yielding 76 cases. J Gastrointest Surg 2010;14:1052-61.
12. Jeanniard-Malet O, Caillol F, Pesenti C, et al. Short-term results of 42 endoscopic ampullectomies: a single center experience. Scand J Gastroenterol 2011;46:1014-9.
13. Patel R, Davitte J, Varadarajulu S, Wilcox CM. Endoscopic resection of ampullary adenomas: complications and outcomes. Dic Dis Sci 2011;56:3235-40.
14. Boix J, Lorenzo-Zunica V, Moreno De Vega V, et al. Endoscopic resection of ampullary tumors: 12-year review of 21 cases. Surg Endosc 2009;23:45-9.
15. Jung MK, Cho CM, Park SY, et al. Endoscopic resection of ampullary neoplasms: a single-center experience. Surg Endosc 2009;23:2568-74.
16. Williamson JML, Thorn CC, Spalding D, Williamson RC. Pancre- atic and peripancreatic somatostatinomas. Ann R Coll Surg Engl 2011;93:356-60.