BibTex RIS Kaynak Göster

Heparin and insulin regimen in the treatment of a patient with acute pancreatitis caused by hypertriglyceridemia

Yıl 2005, Cilt: 4 Sayı: 2, 131 - 134, 01.08.2005

Öz

Hypertriglyceridemia is an important and under-diagnosed etiology of acute non-biliary pancreatitis. There has been no standardized protocol to treat these patients. Our patient was a case with severe acute pancreatitis caused by hypertriglyceridemia. We gave a treatment protocol consisting of heparin and insulin combination to stimulate lipoprotein-lipase activity. The patient's parameters were all improved at the end of the treatment. Our aim was to present this case of acute pancreatitis secondary to hypertriglyceridemia, including differential diagnosis and treatment approach.

Kaynakça

  • Henzen C, Rock M, Schnieper C, et al. Heparin and insulin in the treatment of acute hypertriglyceridemia-induced pancreatitis. Schweiz Med Wochenschr. 1999; 129(35): 1242-8.
  • Toskes PP. Hyperlipidemic pancreatitis. Gastroenterol Clin North Am 1990; 19: 783-791.
  • Searles GE, Ooi TC. Underrecognition of chylomicronemia as a ca- use of acute pancreatitis. CMAJ 1992; 147: 1806-1808.
  • Kimura W, Mossner J. Role of hypertriglyceridemia in the pathoge- nesis of experimental acute pancreatitis in rats. Int J Pancreatol 1996; 20: 177-184.
  • Thompson GR. Primary hyperlipidaemia. Br Med Bull 1990; 46: 986-1004.
  • Dominguez-Munoz JE, Malfertheiner P, Ditschuneit HH, et al. Hyperlipidemia in acute pancreatitis. Relationship with etiology, onset, and severity of the disease. Int J Pancreatol. 1991; 10(3-4): 261-7.
  • Fortson MR, Freedman SR, Webster PD 3rd: Clinical assesment of hyperlipidemic pancreatitis. Am J Gastroenterol 1995; 90: 2134.
  • Raeven GM. Pathophysiology of insulin resistance in human dise- ase. Physiol Rev 1995; 75: 473-86.
  • Malloy MJ, Kane JP. Disorders of lipoprotein metabolism In: Gre- enspan FS, Gardner DG. Basic and Clinical Endocrinology 7thEd. Lange MB Mc-Grav-Hill Comp 2004: 766-93.
  • Wilson DE, Emi M, Iverius P-H, et al. Phenptypic expression of he- terozygous lipoprotein lypase deficiency in the extended pedigree of a probend homozygous for a missense mutation J Clin Invest 1990; 86: 735-750.
  • Berger Z, Quera R, Poniachik J, et al. Heparin and insulin treat- ment of acute pancreatitis caused by hypertriglyceridemia. Experi- ence of 5 cases. Rev Med Chil. 2001; 129(12): 1373-8.
  • Yeh JH, Chen JH, Chiu HC. Plasmapheresis for hyperlipidemic pancreatitis. J Clin Apheresis. 2003; 18(4): 181-5.
  • Mao E, Tang Y, Han T, et al. Effects of short veno-venous hemofilt- ration on severe acute pancreatitis. Zhonghua Waike Zazhi 1999; 37: 141-143.
  • Mao E-Q, Tang Y-Q, Zhang S-D. Formalized therapeutic guideline for hyperlipidemic severe acute pancreatitis. World J Gastroenterol 2003; 9(11): 2622-2626.

Hipertrigliseridemi nedenli akut pankreatit tedavisinde heparin ve insülin rejimi uygulanan bir olgu

Yıl 2005, Cilt: 4 Sayı: 2, 131 - 134, 01.08.2005

Öz

Hipertrigliseridemi, akut nonbiliyer pankreatitin önemli ve gözardı edilen sebeplerindendir. Bu hastaların tedavisinde halen standart bir protokol yoktur. Hastamız, hipertrigliseridemi zemininde gelişen bir akut nekrotizan pankreatit olgusu idi. Hastaya, lipoprotein lipaz aktivitesini arttırmaya yönelik insülin ve heparin kombinasyonundan oluşan bir tedavi protokolu verdik. Tedavi sonunda hastanın tüm verileri düzeldi. Amacımız hipertrigliseridemiye sekonder gelişen bu akut pankreatit olgusunu, ayırıcı tanı ve tedavi yaklaşımını sunmak idi.

Kaynakça

  • Henzen C, Rock M, Schnieper C, et al. Heparin and insulin in the treatment of acute hypertriglyceridemia-induced pancreatitis. Schweiz Med Wochenschr. 1999; 129(35): 1242-8.
  • Toskes PP. Hyperlipidemic pancreatitis. Gastroenterol Clin North Am 1990; 19: 783-791.
  • Searles GE, Ooi TC. Underrecognition of chylomicronemia as a ca- use of acute pancreatitis. CMAJ 1992; 147: 1806-1808.
  • Kimura W, Mossner J. Role of hypertriglyceridemia in the pathoge- nesis of experimental acute pancreatitis in rats. Int J Pancreatol 1996; 20: 177-184.
  • Thompson GR. Primary hyperlipidaemia. Br Med Bull 1990; 46: 986-1004.
  • Dominguez-Munoz JE, Malfertheiner P, Ditschuneit HH, et al. Hyperlipidemia in acute pancreatitis. Relationship with etiology, onset, and severity of the disease. Int J Pancreatol. 1991; 10(3-4): 261-7.
  • Fortson MR, Freedman SR, Webster PD 3rd: Clinical assesment of hyperlipidemic pancreatitis. Am J Gastroenterol 1995; 90: 2134.
  • Raeven GM. Pathophysiology of insulin resistance in human dise- ase. Physiol Rev 1995; 75: 473-86.
  • Malloy MJ, Kane JP. Disorders of lipoprotein metabolism In: Gre- enspan FS, Gardner DG. Basic and Clinical Endocrinology 7thEd. Lange MB Mc-Grav-Hill Comp 2004: 766-93.
  • Wilson DE, Emi M, Iverius P-H, et al. Phenptypic expression of he- terozygous lipoprotein lypase deficiency in the extended pedigree of a probend homozygous for a missense mutation J Clin Invest 1990; 86: 735-750.
  • Berger Z, Quera R, Poniachik J, et al. Heparin and insulin treat- ment of acute pancreatitis caused by hypertriglyceridemia. Experi- ence of 5 cases. Rev Med Chil. 2001; 129(12): 1373-8.
  • Yeh JH, Chen JH, Chiu HC. Plasmapheresis for hyperlipidemic pancreatitis. J Clin Apheresis. 2003; 18(4): 181-5.
  • Mao E, Tang Y, Han T, et al. Effects of short veno-venous hemofilt- ration on severe acute pancreatitis. Zhonghua Waike Zazhi 1999; 37: 141-143.
  • Mao E-Q, Tang Y-Q, Zhang S-D. Formalized therapeutic guideline for hyperlipidemic severe acute pancreatitis. World J Gastroenterol 2003; 9(11): 2622-2626.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Şerif Yılmaz Bu kişi benim

Mehmet Dursun Bu kişi benim

Fikri Canoruç Bu kişi benim

Alpaslan Tuzcu Bu kişi benim

Hatice Akay Bu kişi benim

Ramazan Danış Bu kişi benim

Ergün Parmaksız Bu kişi benim

Yayımlanma Tarihi 1 Ağustos 2005
Yayımlandığı Sayı Yıl 2005 Cilt: 4 Sayı: 2

Kaynak Göster

APA Yılmaz, Ş., Dursun, M., Canoruç, F., Tuzcu, A., vd. (2005). Hipertrigliseridemi nedenli akut pankreatit tedavisinde heparin ve insülin rejimi uygulanan bir olgu. Akademik Gastroenteroloji Dergisi, 4(2), 131-134.

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