Coincidence of hepatoportal vein thrombosis and malignity in patients with noncirrhotic portal hypertension

Yıl 2003, Cilt: 2 Sayı: 3, - , 01.12.2003

Ali Tüzün İnce Cengiz Bölükbaş Tülin Kendir Aliye Soylu Can Dolapçıoğlu Hakan Güveli Remzi Dalay Oya Övünç

Öz

Background and aim: Malignancies can cause noncirrhotic portal hypertension by affecting the hepatoportal vascular (right, left and middle hepatic veins and portal vein) system with metastasis, thrombosis, viscosity changes and vasculitis. The aim of this study was to assess the coincidence of hepatoportal vein thrombosis and malignancies in patients with noncirrhotic portal hypertension. Material and methods: Patients admitted to our clinic between 1995-2000 with noncirrhotic portal hypertension who had malignancy and hepatoportal vein thrombosis were assessed retrospectively. Results: Sixty-four percent (n:28) of patients with noncirrhotic portal hypertension were K [n:18, mean:36.8, median:33, range:20-71], 36% were E [n:10, mean:46.8, median:37, range:14-76]. Fifty-seven percent of noncirrhotic portal hypertension patients had hepatoportal vein thrombosis [n:16, 8 E (mean:37, medium: 48, range:23-65), 8 K (mean:31, medium:35, range:23-65)]. Onethird of thromboses were located in hepatic vein, two-thirds were located in portal vein. Among the etiologies of thromboses were: 9 patients (56.25%) with malignancies [2 hepatomas, 1 chronic myeloid leukemia, 1 Wilms tumor, 1 cholangiocarcinoma, 1 prostate cancer, 1 pancreatic cancer, 1 neuroendocrine tumor, 1 gynecologic malignancy]; 3 patients (18.75%) with low levels of protein S, C and antithrombin-III, 1 patient (6.25%) with hyperviscosity syndrome of polycythemia vera, 1 patient (6.25%) with pancreatitis and 2 patients (12.5%) with no etiology. Conclusion: Malignancy probability is quite high in patients with hepatoportal vein thrombosis and noncirrhotic portal hypertension and thus should be investigated.

Anahtar Kelimeler

Hepatoportal vein thrombosis, malignancies, noncirrhotic portal hypertension

Nonsirotik portal hipertansiyonlu hastalarda hepatoportal ven trombozu ile malignitelerin birlikteliği

Öz

Giriş ve amaç: Maligniteler metastaz, tromboz, viskozite değişiklikleri ve vaskülit gibi nedenlerle hepatoportal venöz (portal ven ile sağ, sol ve orta hepatik venler) sistemi etkileyerek nonsirotik portal hipertansiyon sebebi olabilirler. Bu çalışmanın amacı nonsirotik portal hipertansiyonlu hastalarda hepatoportal ven trombozlarıyla malignitelerin birlikteliğini değerlendirmektir. Gereç ve yöntem: Kliniğimize 1995-2000 yılları arası nda başvuran nonsirotik portal hipertansiyon vakaları arasından malignite ve hepatoportal ven trombozlu hastalar retrospektif yolla değerlendirilmiştir. Bulgular: Nonsirotik portal hipertansiyonlu 28 hastanın 36%'sı E [n:10, mean: 46.8, median:37, range:14-76], %64'ü K [n:18, mean:36.8, median:33, range:20-71]. Hastaların 57%'sinde [n:16, 8 E (mean:37, medium: 48, range:23-65), 8 K (mean:31, medium:35, range: 23-65)] hepatoportal ven trombozu vardı. Trombozların 1/3'ü hepatik, 2/3'ü portal venlerde lokalizeydi. Trombozların etiolojisinde: 9 hastada (56,25%) malignite [2 hepatoma, 1 kronik myeloid lösemi, 1 kolanjiokarsinoma, 1 Wilms tümörü, 1 prostat kanseri, 1 pankreas kanseri, 1 nöroendokrin tümör, 1 jinekolojik malignite], 3 hastada (18,75%) düşük protein S, C ve antitrombin-III seviyeleri, 1 hastada (6,25%) Polistemia Vera'ya bağlı hiperviskosite sendromu ve 1 hastada (6,25%) pankreatitis varken 2 hastada (12,5%) etioloji saptanamadı. Sonuç: Hepatoportal ven trombozu olan nonsirotik portal hipertansiyonlu hastalarda malignite etioloji olasılığı yüksektir ve bu nedenle mutlaka aranılmalıdır.

Anahtar Kelimeler

Hepatoportal ven trombozu, maligniteler, nonsirotik portal hipertansiyon