Prognostic Utility of C-Reactive Protein / Albumin Ratio in Cirrhotic Patients

Yıl 2018, Cilt: 17 Sayı: 3, 110 - 116, 29.12.2018

Mustafa Kaplan İhsan Ateş Meral Akdoğan Kayhan Sabite Kaçar Muhammet Yener Akpınar Volkan Gökbulut Orhan Coşkun Adem Aksoy Ufuk Barış Kuzu

https://doi.org/10.17941/agd.440465

Öz

Backgroundand Aims: In this study, we investigated the relationship between C-reaktive
protein (CRP)/Albumin ratio (CAR) and hepatocellular carcinoma (HCC), hepatic
encephalopathy (HES), mortality, Child-Pugh and MELD scores in newly diagnosed
cirrhotic patients.

Material and Methods: This study was performed retrospectively by examining newly
diagnosed cirrhotic patients records who applied to Gastroenterology and
Hepatology polyclinic between 2011 and 2017. Patients who diagnosed with HES, HCC or spontaneous bacterial
peritonitis at admission and those younger than 18 years old were excluded from
the study.

Results:
The study population was consisted of 118 patients,
78 men (66.1%) and 40 women (33.9%). The mean
age of the patients was 50.3±11.7 years. The
most common etiologic factors of cirrhosis were hepatitis B (37.3%),
cryptogenic (17.8%) and hepatitis C (11.9%). The
mean follow-up period of the patients was 48 months. In the multivariate
stepwise Cox regression model in which risk factors were included; HES
development (HR: 4,21; p=0,001), initial MELD score (HR: 1,17; p <0.001) and
CAR (HR=1.22; p <0.001) were found to be independent predictors for
mortality risk. A 1% increase in CAR was found to increase the mortality risk
1.22-fold. The cut-off value of CAR for predicting mortality was found ≥2.4
with 77.1% sensitivity and 95.2% specificity. Devolopment
of HES (35.5% vs 10.3%, p=0.004), the mean Child-Pugh score (7.4±1.9 vs 6.4±1.6,
p <0.001), the mean MELD score (14,2±3,7 vs 11,8±4,1; p <0,001) and the
proportion of dead patients (87,1% vs 9,2%, p <0,001) were significantly
higher in patients with CAR 2.4 and above.

Conclusion: CAR is a easily measured parameter with high specificity that can
be used for prediction of mortality and cirrhosis complications in newly
diagnostic cirrhotic patients.

Anahtar Kelimeler

CRP, albumin, hepatic encephalopathy, Child-Pugh score, MELD score

C-Reaktif Protein/Albümin Oranının Sirotik Hastalarda Prognostik Amaçlı Kullanımı

Öz

Giriş ve Amaç: Bu çalışmada yeni tanı siroz hastalarında tanı anındaki C-reaktif
protein (CRP)/Albümin oranının (CAO) hepatosellüler karsinom (HCC), hepatik
ensefalopati (HES), mortalite, Child-Pugh ve MELD skorları ile ilişkisini
araştırdık.

Gereç ve Yöntem: Bu
çalışma 2011-2017 yılları arasında Gastroenteroloji ve Hepatoloji polikliniğe
başvuran yeni tanı siroz hastalarının hasta kayıtları incelenerek retrospektif
olarak yapılmıştır. Çalışmaya alınma anında spontan bakteriyel peritonit, HES
veya HCC tanısı olanlar ve 18 yaşından küçük olanlar çalışmadan dışlanmıştır.

Bulgular: Araştırma
popülasyonu 78 erkek (%66,1) ve 40 kadın (%33,9) hasta olmak üzere 118 kişiden
oluştu. Hastaların ortalama yaşı 50,3±11,7 yıldı. Hastalarda sirozun en sık
etyolojik faktörleri hepatit B (%37,3), kriptojenik (%17,8) ve hepatit C
(%11,9) idi.  Hastaların ortalama takip
süresi 48 aydı. Risk faktörlerinin dahil edildiği çok değişkenli stepwise Cox
regresyon modelinde; HES gelişmesi (HR:4,21; p=0,001), başlangıç MELD skoru
(HR:1,17; p<0,001) ve CAO (HR=1,22; p<0,001) mortalite riskini öngören
bağımsız prediktörler olarak saptandı. CAO’da %1’lik artış 1,22 kat mortalite
riskini arttırdığı saptandı. Mortaliteyi öngörmede CAO’a ait kestirim
değeri  %77,1 duyarlılık ve %95,2
özgüllük ile ≥2,4 olarak saptandı. CAO 2,4 ve üzeri olan hastalarda HES
gelişmesi (%35,5 vs %10,3; p=0,004), ortalama Child-Pugh skoru (7,4±1,9 vs
6,4±1,6; p<0,001), ortalama MELD skoru (14,2±3,7 vs 11,8±4,1; p<0,001) ve
ölenlerin oranı (%87,1 vs %9,2; p<0,001) daha yüksek saptandı.

Sonuç: CAO yeni tanı sirotik hastalarda mortalite ve siroz
komplikasyonlarını öngörmede kullanılabilecek kolay ölçülebilen ve spesifitesi
yüksek bir parametredir.  

Anahtar Kelimeler

CRP, albumin, hepatik ensefalopati, Child-Pugh skoru, MELD skoru

Kaynakça

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