Göz Kuruluğu olan hastalarda Helikobakter Pilori varlığı ve endoskopik bulguların özellikleri

Öz

Amaç: Helicobacter pylori, peptik ülser ve mide adenokarsinomunun yanı sıra birçok mide dışı tutuluma da neden olmaktadır. Yapılan çalışmalarda çelişkili sonuçlar bildirilse de bazı göz hastalıklarının Helicobacter pylori ile ilişkili olduğu rapor edilmiştir. Çalışmamızda kuru göz varlığı ile Helicobacter pylori pozitifliği arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve yöntem: Demografik veriler, uyuşturucu, sigara, alkol kullanımı, endoskopik, histolojik bulgular ve kuru göz varlığı dokümante edildi. Kuru göz hastaları ve kontrol grubu arasında endoskopik ve histopatolojik bulgular karşılaştırıldı. Veriler istatistiksel olarak analiz edildi ve p<0,05 olan değerler anlamlı kabul edildi. Bulgular: Çalışmaya kuru gözü olan 60, kuru gözü olmayan 36 hasta dahil edildi. Kuru gözü olan hastalarda Helicobacter pylori varlığı anlamlı olarak daha yüksek bulundu. Kuru gözü olan hasta grubunda Helicobacter pylori görülme sıklığı %78,3 (n=43) iken, kuru gözü olmayan grupta Helicobacter pylori görülme sıklığı %50,0 (n=18) idi (p=0,004). Endoskopik ve histopatolojik bulgular açısından gruplar arasında fark yoktu. Sonuç: Bakteriyel virülans faktörü ile konak ve çevresel faktörlerin etkileşimi sonucu Helicobacter pylori'nin birçok ekstragastrik tutulumla da ilişkili olduğu bilinmektedir. Bu nedenle kuruluk gibi göz hastalıklarının varlığında Helicobacter pylori varlığının araştırılıp pozitif ise tedavi edilmelidir.

Anahtar Kelimeler

• Kuru göz
• Helicobacter pylori
• Endoskopi

Presence of Helicobacter Pylori and features of endoscopic findings in patients with Dry Eye

Öz

Aim: Helicobacter pylori causes peptic ulcer, gastric adenocarcinoma, and also causes many extra-gastric involvement. Although contradictory results have been reported in previous studies, some ocular diseases have been associated with Helicobacter pylori infection. Our study aimed to investigate the relationship between the presence of dry eye and Helicobacter pylori infection. Material and Method: Demographic data, drug, smoking, alcohol use, endoscopic and histological findings, and presence of dry eye were documented. Endoscopic and histopathological findings were compared between patients with dry eye and the control group. The data were analyzed statistically. Statistical significance was set at P <0.05. Results: Sixty patients with dry eye and 36 without dry eye were included in the study. The presence of Helicobacter pylori was significantly higher in patients with dry eye. While the incidence of Helicobacter pylori was 78.3% (n=43) in the patient group with dry eye, the incidence of Helicobacter pylori was 50.0% (n=18) in the group without dry eye (p=0.004). There were no differences between the groups in terms of endoscopic and histopathological findings. Conclusions: Helicobacter pylori is also associated with extragastric involvement because of the interaction between bacterial virulence factors and host and environmental factors. Therefore, in the presence of eye diseases, such as dryness, the presence of Helicobacter pylori should be investigated and treated if positive.

Anahtar Kelimeler

• Dry eye
• Helicobacter pylori
• Endoscopy.

Kaynakça

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