Relationship between mean platelet volume and disease activation in ankylosing spondylitis

Yıl 2025, Cilt: 3 Sayı: 1, 3 - 6, 01.02.2025

Ozan Durmaz , Adnan Özkahraman , Nüket Bayram Kayar , Mehmet Ali Bilgili , Yusuf Kayar , Refik Demirtunç

https://doi.org/10.61845/agrimedical.1433061

Öz

Aim: In our study, we aimed to find the relationship between the activity of Ankylosing Spondylitis (AS) disease and mean platelet volume (MPV) and examine the relationship between disease activity and other parameters (Hemoglobin (Hb), Hematocrit (Htc), platelet, ESR, CRP.
Material and Method: 180 patients with an average age of 33.8±10.3 years (age range:18-67) participated in the study (number of AS patients:99 F/M:38/61, number of healthy controls:81 F/M:32/49). Within the first 24 hours after arriving at the hospital, blood was taken for all patients, and hemogram examinations were performed. The files of patients with AS were examined retrospectively and groups with active and inactive AS were determined according to the BASDAI score. The healthy control group and the patient group with AS were compared in terms of parameters such as leukocyte, Hb, Htc, platelet, MPV, CRP and ESH.
Results: Patients with AS were shown to have significantly greater values of leukocytes, platelets, CRP, and ESR, and lower values of Hb, Hct, and MPV when compared to the control group (p<0,05). Furthermore, compared to the control group, inflammatory markers such as CRP and ESH were higher in the Active AS and inactive AS subgroups, but MPV and Hb Hct levels were significantly lower (p<0,05).
Conclusions: While inflammatory parameters were significantly higher in the AS patient group, MPV and Hb values were also shown to be lower. It was shown that the current parameters examined could be an inexpensive biomarker both in the diagnosis and treatment follow-up of AS. Larger controlled prospective research is nevertheless required on this topic.

Anahtar Kelimeler

Ankylosing spondylitis, activation, Mean platelet volume.

Ankilozan spondilit’te ortalama trombosit hacmiyle hastalık aktivasyonunun ilişkisi

Öz

Amaç: Çalışmamızda, Ankilozan Spondilit (AS) hastalığının aktivitesi ile ortalama trombosit hacmi OTH arasındaki ilişkiyi bulmak ve hastalık aktivitesi ile diğer parametrelerle (Hemoglobin (Hb), Hematokrit (Htc), platelet, ESH, CRP olan ilişkisini incelemeyi amaçladık.
Gereç ve yöntem: Çalışmaya ortalama yaşları 33,8 ± 10,3 yıl (yaş aralığı: 18-67) olan 180 katılımcı alındı (AS hasta sayısı: 99 K/E:38/61, sağlıklı kontrol sayısı: 81 K/E:32/49). Hastaneye geldikten sonraki ilk 24 saat içinde, tüm hastalarahemogram tetkiki yapıldı. AS’li hastaların dosyaları retrospektif olarak incelendi ve BASDAI skoruna göre aktif ve inaktif AS’li gruplar belirlendi. Sağlıklı kontrol grubu ve AS olan hasta grubu, lökosit, Hb, Htc, platelet, OTH, CRP ve ESH gibi parametreler açısından karşılaştırıldı.
Bulgular: AS’li hastalarda kontrol grubuna göre lökosit, platelet, CRP ve ESH değerlerinin anlamlı olarak daha yüksek, Hb, Hct ve OTH’nin daha düşük olduğu saptandı (p<0,05). Ayrıca AS'li hasta alt gruplarından hem Aktif AS hem de inaktif AS hasta grubunda kontrol grubuna göre CRP ve ESH gibi inflamatuar parametrelerin daha yüksek, buna karşılık Hb, Hct ve OTH değerinin anlamlı olarak daha düşük olduğu görüldü (p<0,05).
Sonuç: AS hasta grubunda inflamatuar parametreler, anlamlı olarak daha yüksek iken OTH ve Hb değerinin düşük olduğu gösterildi. Bakılan mevcut parametrelerin AS’nin gerek tanı, gerekse tedavi takibinde ucuz bir biyobelirteç olabileceği gösterildi. Ancak bu konuda daha geniş kontrollü prospektif çalışmalara gereksinim duyulmaktadır.

Anahtar Kelimeler

Ankilozan spondilit, aktivasyon, Mean platelet volume.

Etik Beyan

20.05.2013 tarihli İstanbul Haydarpaşa Numune hastanesinden alınmıştır.

Destekleyen Kurum

Yok

Teşekkür

Yok

Kaynakça

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