Araştırma Makalesi
BibTex RIS Kaynak Göster

EVALUATİON OF THE ANTİBACTERİAL POTENTİALS OF ESSENTİAL OİLS FROM LAVANDULA ANGUSTİFOLİA L. AND SALVİA OFFİCİNALİS L. CULTİVATED UNDER THE ECOLOGİCAL CONDİTİONS OF KIRŞEHİR AGAİNST CLİNİCALLY SİGNİFİCANT PATHOGENS

Yıl 2025, Cilt: 1 Sayı: 1, 11 - 17, 26.12.2025
https://izlik.org/JA88XG92EC

Öz

The potential side effects of traditional antimicrobial drugs and the
development of bacterial resistance pose a serious threat to public health.
This situation has made the search for natural and plant-based alternatives
increasingly important. Today, many aromatic and medicinal plants are
widely used by the public not only for nutritional purposes but also as
protective agents against infections. In the present study, the antimicrobial
effects of essential oils obtained from Lavandula angustifolia (lavender)
and Salvia officinalis (sage), cultivated under the ecological conditions of
Kırşehir, were evaluated. The antibacterial activities of the essential oils
were investigated against seven clinically significant bacterial strains using
the disk diffusion method, MIC (Minimum Inhibitory Concentration), and
MBC (Minimum Bactericidal Concentration) analyses. The results revealed
that both plants exhibited significant antimicrobial activity against both
Gram-positive and Gram-negative bacteria. L. angustifolia oil stood out
with broader inhibition zones and lower MIC values, particularly against L.
angustifolia essential oil showed higher efficacy, particularly forming large
inhibition zones against B. cereus (25 mm) and S. aureus (20 mm). The
MIC value was determined to be 0.39% for E. coli and E. faecalis,
indicating effectiveness even at low concentrations. S. officinalis essential
oil exhibited its lowest MIC value (0.39%) against the S. aureus strain. The
findings suggest that the essential oils obtained from these plants cultivated
in the Kırşehir climate could be considered as potential natural
antimicrobial agents in the fight against resistant bacteria.

Kaynakça

  • Abou Baker, DH, Amarowicz, R, Kandeil, A, Ali, MA, & Ibrahim, EA. (2021). Antiviral activity of Lavandula angustifolia L. and Salvia officinalis L. essential oils against avian influenza H5N1 virus. Journal of Agriculture and Food Research, 4, 100135.
  • Alizadeh Behbahani, B, & Shahidi, F. (2019). Melissa officinalis essential oil: Chemical compositions, antioxidant potential, total phenolic content and antimicrobial activity. Nutrition and food in health and disease, 6(1), 17- 25.
  • Andrys, D, Kulpa, D, Grzeszczuk, M, & Białecka, B. (2018). Influence of jasmonic acid on the growth and antimicrobial and antioxidant activities of Lavandula angustifolia Mill. propagated in vitro. Folia Horticulturae, 30(1), 3-13.
  • Arnao, MB, Cano, A, & Acosta, M. (2001). The hydrophilic and lipophilic contribution to total antioxidant activity. Food Chemistry, 73(2), 239-244.
  • Arzani, A, & Ashraf, M. (2016). Smart engineering of genetic resources for enhanced salinity tolerance in crop plants. Critical Reviews in Plant Sciences, 35(3), 146-189.
  • Benbrahim, C, Barka, MS, Basile, A, Maresca, V, Flamini, G, Sorbo, S, Carraturo, F, Notariale, R, Piscopo, M, & Khadir, A. (2021). Chemical composition and biological activities of oregano and lavender essential oils. Applied Sciences, 11(12), 5688.
  • Diekema, DJ, Hsueh, P-R, Mendes, RE, Pfaller, MA, Rolston, KV, Sader, HS, & Jones, RN. (2019). The microbiology of bloodstream infection: 20-year trends from the SENTRY antimicrobial surveillance program. Antimicrobial agents and chemotherapy, 63(7), 10.1128/aac. 00355-00319.
  • Eliuz, EAE, Ayas, D, & Goksen, G. (2016). Antibacterial Actions and Potential Phototoxic Effects of Volatile oils of Foeniculum sp.(fennel), Salvia sp.(sage), Vitis sp.(grape), Lavandula sp.(lavender). Natural and Engineering Sciences, 1(3), 10-22.
  • Ezema, CA, Ezeorba, TPC, Aguchem, RN, & Okagu, IU. (2022). Therapeutic benefits of Salvia species: A focus on cancer and viral infection. Heliyon, 8(1).
  • Fredriksson-Ahomaa, M. (2009). Epidemiology of human Yersinia pseudotuberculosis infection. İşcan, G, Kı̇ rı̇ mer, N, Kürkcüoǧlu, Mn, Başer, HC, & Demirci, F. (2002). Antimicrobial screening of Mentha piperita essential oils. Journal of Agricultural and Food Chemistry, 50(14), 3943-3946.
  • Jean, S-S, Harnod, D, & Hsueh, P-R. (2022). Global threat of carbapenem-resistant gram-negative bacteria. Frontiers in cellular and infection microbiology, 12, 823684.
  • Jirovetz, L, Buchbauer, G, Denkova, Z, Stoyanova, A, Murgov, I, Schmidt, E, & Geissler, M. (2005). Antimicrobial testinas and gas chromatoaraphic analvsis of pure oxvaenated monoterpenes 1.8-cineole, α-terpineol, terpinen4-ol and camphor as well as target comoounds in essential oils of pine (Pinus pinaster), rosemary (Rosmarinus officinalis), tea tree (Melaleuca alternifolia). Scientia Pharmaceutica, 73(1), 27-39.
  • Katar, D, Can, M, & Katar, N. (2020). Effect of different locations on essential oil content and chemical composition in Lavandin (Lavandula× intermedia Emeric ex Loisel.).
  • Khan, HA, Ahmad, A, & Mehboob, R. (2015). Nosocomial infections and their control strategies. Asian pacific journal of tropical biomedicine, 5(7), 509-514.
  • Lal, R, Pankhuri, G, Chanotiya, C, Anand, M, & Ranjana, M. (2020). Genetics of essential oil yield and their component traits in vetiver (Chrysopogon zizanioides (L.) Roberty). J. Med. Plants. Studies, 8(4), 56-64.
  • Mahjabeen, F, Saha, U, Mostafa, MN, Siddique, F, Ahsan, E, Fathma, S, Tasnim, A, Rahman, T, Faruq, R, & Sakibuzzaman, M. (2022). An update on treatment options for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia: a systematic review. Cureus, 14(11).
  • Mohammadinejad, R, Shavandi, A, Raie, DS, Sangeetha, J, Soleimani, M, Hajibehzad, SS, Thangadurai, D, Hospet, R, Popoola, JO, & Arzani, A. (2019). Plant molecular farming: production of metallic nanoparticles and therapeutic proteins using green factories. Green chemistry, 21(8), 1845-1865.
  • Mourabiti, F, Derdak, R, El Amrani, A, Momen, G, Timinouni, M, Soukri, A, El Khalfi, B, & Zouheir, Y. (2024). The antimicrobial effectiveness of Rosmarinus officinalis, Lavandula angustifolia, and Salvia officinalis essential oils against Klebsiella pneumoniae and Pseudomonas aeruginosa in vitro and in silico. South African Journal of Botany, 168, 112-123.
  • Santajit, S, & Indrawattana, N. (2016). Mechanisms of antimicrobial resistance in ESKAPE pathogens. BioMed research international, 2016(1), 2475067.
  • Soleimani, M, Arzani, A, Arzani, V, & Roberts, TH. (2022). Phenolic compounds and antimicrobial properties of mint and thyme. Journal of Herbal Medicine, 36, 100604.
  • Xie, Y, Xu, Y, Chen, K, Chen, C, Huang, J, Chen, Q, & Shi, P. (2024). Microbiological and Antimicrobial Pattern of Diabetic Foot Ulcers at a Tertiary Care Center in East China. The International Journal of Lower Extremity Wounds, 23(1), 104-108.
  • Yao, H, Liu, J, Jiang, X, Chen, F, Lu, X, & Zhang, J. (2021). Analysis of the clinical effect of combined drug susceptibility to guide medication for carbapenem-resistant klebsiella pneumoniae patients based on the kirby–bauer disk diffusion method. Infection and drug resistance, 79-87.

Yıl 2025, Cilt: 1 Sayı: 1, 11 - 17, 26.12.2025
https://izlik.org/JA88XG92EC

Öz

Kaynakça

  • Abou Baker, DH, Amarowicz, R, Kandeil, A, Ali, MA, & Ibrahim, EA. (2021). Antiviral activity of Lavandula angustifolia L. and Salvia officinalis L. essential oils against avian influenza H5N1 virus. Journal of Agriculture and Food Research, 4, 100135.
  • Alizadeh Behbahani, B, & Shahidi, F. (2019). Melissa officinalis essential oil: Chemical compositions, antioxidant potential, total phenolic content and antimicrobial activity. Nutrition and food in health and disease, 6(1), 17- 25.
  • Andrys, D, Kulpa, D, Grzeszczuk, M, & Białecka, B. (2018). Influence of jasmonic acid on the growth and antimicrobial and antioxidant activities of Lavandula angustifolia Mill. propagated in vitro. Folia Horticulturae, 30(1), 3-13.
  • Arnao, MB, Cano, A, & Acosta, M. (2001). The hydrophilic and lipophilic contribution to total antioxidant activity. Food Chemistry, 73(2), 239-244.
  • Arzani, A, & Ashraf, M. (2016). Smart engineering of genetic resources for enhanced salinity tolerance in crop plants. Critical Reviews in Plant Sciences, 35(3), 146-189.
  • Benbrahim, C, Barka, MS, Basile, A, Maresca, V, Flamini, G, Sorbo, S, Carraturo, F, Notariale, R, Piscopo, M, & Khadir, A. (2021). Chemical composition and biological activities of oregano and lavender essential oils. Applied Sciences, 11(12), 5688.
  • Diekema, DJ, Hsueh, P-R, Mendes, RE, Pfaller, MA, Rolston, KV, Sader, HS, & Jones, RN. (2019). The microbiology of bloodstream infection: 20-year trends from the SENTRY antimicrobial surveillance program. Antimicrobial agents and chemotherapy, 63(7), 10.1128/aac. 00355-00319.
  • Eliuz, EAE, Ayas, D, & Goksen, G. (2016). Antibacterial Actions and Potential Phototoxic Effects of Volatile oils of Foeniculum sp.(fennel), Salvia sp.(sage), Vitis sp.(grape), Lavandula sp.(lavender). Natural and Engineering Sciences, 1(3), 10-22.
  • Ezema, CA, Ezeorba, TPC, Aguchem, RN, & Okagu, IU. (2022). Therapeutic benefits of Salvia species: A focus on cancer and viral infection. Heliyon, 8(1).
  • Fredriksson-Ahomaa, M. (2009). Epidemiology of human Yersinia pseudotuberculosis infection. İşcan, G, Kı̇ rı̇ mer, N, Kürkcüoǧlu, Mn, Başer, HC, & Demirci, F. (2002). Antimicrobial screening of Mentha piperita essential oils. Journal of Agricultural and Food Chemistry, 50(14), 3943-3946.
  • Jean, S-S, Harnod, D, & Hsueh, P-R. (2022). Global threat of carbapenem-resistant gram-negative bacteria. Frontiers in cellular and infection microbiology, 12, 823684.
  • Jirovetz, L, Buchbauer, G, Denkova, Z, Stoyanova, A, Murgov, I, Schmidt, E, & Geissler, M. (2005). Antimicrobial testinas and gas chromatoaraphic analvsis of pure oxvaenated monoterpenes 1.8-cineole, α-terpineol, terpinen4-ol and camphor as well as target comoounds in essential oils of pine (Pinus pinaster), rosemary (Rosmarinus officinalis), tea tree (Melaleuca alternifolia). Scientia Pharmaceutica, 73(1), 27-39.
  • Katar, D, Can, M, & Katar, N. (2020). Effect of different locations on essential oil content and chemical composition in Lavandin (Lavandula× intermedia Emeric ex Loisel.).
  • Khan, HA, Ahmad, A, & Mehboob, R. (2015). Nosocomial infections and their control strategies. Asian pacific journal of tropical biomedicine, 5(7), 509-514.
  • Lal, R, Pankhuri, G, Chanotiya, C, Anand, M, & Ranjana, M. (2020). Genetics of essential oil yield and their component traits in vetiver (Chrysopogon zizanioides (L.) Roberty). J. Med. Plants. Studies, 8(4), 56-64.
  • Mahjabeen, F, Saha, U, Mostafa, MN, Siddique, F, Ahsan, E, Fathma, S, Tasnim, A, Rahman, T, Faruq, R, & Sakibuzzaman, M. (2022). An update on treatment options for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia: a systematic review. Cureus, 14(11).
  • Mohammadinejad, R, Shavandi, A, Raie, DS, Sangeetha, J, Soleimani, M, Hajibehzad, SS, Thangadurai, D, Hospet, R, Popoola, JO, & Arzani, A. (2019). Plant molecular farming: production of metallic nanoparticles and therapeutic proteins using green factories. Green chemistry, 21(8), 1845-1865.
  • Mourabiti, F, Derdak, R, El Amrani, A, Momen, G, Timinouni, M, Soukri, A, El Khalfi, B, & Zouheir, Y. (2024). The antimicrobial effectiveness of Rosmarinus officinalis, Lavandula angustifolia, and Salvia officinalis essential oils against Klebsiella pneumoniae and Pseudomonas aeruginosa in vitro and in silico. South African Journal of Botany, 168, 112-123.
  • Santajit, S, & Indrawattana, N. (2016). Mechanisms of antimicrobial resistance in ESKAPE pathogens. BioMed research international, 2016(1), 2475067.
  • Soleimani, M, Arzani, A, Arzani, V, & Roberts, TH. (2022). Phenolic compounds and antimicrobial properties of mint and thyme. Journal of Herbal Medicine, 36, 100604.
  • Xie, Y, Xu, Y, Chen, K, Chen, C, Huang, J, Chen, Q, & Shi, P. (2024). Microbiological and Antimicrobial Pattern of Diabetic Foot Ulcers at a Tertiary Care Center in East China. The International Journal of Lower Extremity Wounds, 23(1), 104-108.
  • Yao, H, Liu, J, Jiang, X, Chen, F, Lu, X, & Zhang, J. (2021). Analysis of the clinical effect of combined drug susceptibility to guide medication for carbapenem-resistant klebsiella pneumoniae patients based on the kirby–bauer disk diffusion method. Infection and drug resistance, 79-87.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Biyomühendislik (Diğer)
Bölüm Araştırma Makalesi
Yazarlar

Kübra Öztürk

Emine Bilginoğlu

Elif Sevim

Gönderilme Tarihi 1 Temmuz 2025
Kabul Tarihi 7 Temmuz 2025
Yayımlanma Tarihi 26 Aralık 2025
IZ https://izlik.org/JA88XG92EC
Yayımlandığı Sayı Yıl 2025 Cilt: 1 Sayı: 1

Kaynak Göster

APA Öztürk, K., Bilginoğlu, E., & Sevim, E. (2025). EVALUATİON OF THE ANTİBACTERİAL POTENTİALS OF ESSENTİAL OİLS FROM LAVANDULA ANGUSTİFOLİA L. AND SALVİA OFFİCİNALİS L. CULTİVATED UNDER THE ECOLOGİCAL CONDİTİONS OF KIRŞEHİR AGAİNST CLİNİCALLY SİGNİFİCANT PATHOGENS. Ahi Evran Journal of Engineering Sciences, 1(1), 11-17. https://izlik.org/JA88XG92EC