Toxicodendron succedaneum (L.) Kuntze (synonym: Rhus succedanea L.) is a tree in the family of Anacardiaceae. T. succedaneum has been using to treat diarrhea, nose and gum bleedings, vomiting, dysentery, cough, tuberculosis, fever, asthma, liver ailments, and ear infections in traditional medicines. Phytochemicals such as agathisflavone, rhusflavone, robustaflavone, succedaneaflavanone, and volkensiflavone were isolated from this plant species. The purpose of this review is to analyze, summarize, and document available bioactivity studies of T. succedaneum. The Web of Science, Scopus, ScienceDirect, and PubMed (databases) were used to search relevant published papers between 1900 and November 2020. So far, in vivo is the highest level of scientific evidence available for the reported bioactivities. Various parts of T. succedaneum disclosed such as antibacterial, anticancer, anti-diabetic, anti-inflammatory, antioxidant, and antiviral activities. Anticancer, antioxidant, and antiviral compounds have been identified from this plant species. Further bioactivity and phytochemical studies should make it possible to obtain additional scientific evidence. This minireview work will be useful for future researches involving this plant species.