İYONİZE RADYASYONUN RADYOLOJİ BÖLÜMÜNDE ÇALIŞAN SAĞLIK ÇALIŞANLARI ÜZERİNDEKİ ETKİSİ
Yıl 2023,
Cilt: 5 Sayı: 3, 129 - 134, 31.12.2023
Adem Keskin
,
Recai Aci
,
Murat Arı
Öz
Bu çalışma, sağlık alanında radyasyon bulunan ortamlarda çalışan sağlık çalışanları üzerinde radyasyonun etkileri üzerine tasarlanmıştır. Radyasyon alanlarında çalışan sağlık çalışanları düşük dozda radyasyona maruz kalmaktadır. Bu maruziyetten en çok etkilenen organ tiroiddir. Tiroid uyarıcı hormon düzeyleri ile 5 yıl boyunca radyasyona maruz kalma arasında anlamlı bir ilişki vardır. Radyasyona maruz kalan kişilerde DNA hasarı gelişebilir ve DNA onarım sistemi etkilenebilir. Radyasyon alanında çalışan sağlık çalışanlarının maruz kaldıkları doza bağlı olarak bazı kanser türleri açısından risk altında oldukları söylenebilir. Bu zararlı etkilerden en çok girişimsel radyoloji ve nükleer tıp çalışanları etkilenmektedir. Bu sağlık sorunlarından korunmak veya daha az sağlık sorunu yaşamak için radyasyon alanında çalışan sağlık çalışanlarının her türlü korunma yöntemini uygulamaları gerekmektedir. Bu korunma yöntemleri hem bireysel hem de hasta açısından değerlendirilmelidir. Ayrıca diğer sağlık profesyonelleri de sağlıkta vazgeçilmez bir unsur olan radyasyon ortamından mümkün olduğunca az yararlanmalıdır. Teşhis veya tedavi sırasında radyasyona maruz kalmak iyileşme sürecinde gecikmelere neden olabilir.
Kaynakça
- Ahmed, M., & Ahmed, R. (2022). Radiation in gastroenterology. Gastroenterology Research, 15(6), 285.
- Azzam, E. I., Jay-Gerin, J. P., & Pain, D. (2012). Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett., 327(1-2), 48-60.
- Boice, J. D., Jr., Ellis, E. D., Golden, A. P., Zablotska, L. B., Mumma, M. T., & Cohen, S. S. (2022). Sex-specific lung cancer risk among radiation workers in the million-person study and patients TB-Fluoroscopy. Int J Radiat Biol., 98(4), 769-780.
- Chartier, H., Fassier, P., Leuraud, K., Jacob, S., Baudin, C., Laurier, D., & Bernier, M. O. (2020). Occupational low-dose irradiation and cancer risk among medical radiation workers. Occup Med (Lond)., 70(7), 476-484.
- Choi, K. H., Ha, M., Lee, W. J., Hwang, S. S., Jeong, M., Jin, Y. W., Kim, H. J., Lee, K. Y., Lee, J. E., Kang, J. W., & Kim, H. (2013). Cancer risk in diagnostic radiation workers in Korea from 1996–2002. Int J Environ Res Public Health., 10(1), 314-327.
- Gaetani ,S., Monaco, F., Bracci, M., Ciarapica, V., Impollonia, G., Valentino, M., Tomasetti, M., Santarelli, L., & Amati, M. (2018). DNA damage response in workers exposed to low-dose ionising radiation. Occup Environ Med., 75(10), 724-729.
- Gbetchedji, A. A., Houndetoungan, G. D., Hounsossou, H. C., Journy, N., Haddy, N., Rubino, C., Biaou, O., Medenou, D., Amoussou-Guenou, K. M., de Vathaire, F., & Allodji, R. S. (2020). A systematic review of occupational radiation individual dose monitoring among healthcare workers exposed in Africa. J Radiol Prot,. 40(4), R141.
- Jin, Y., Yaegashi, D., Shi, L., Ishida, M., Sakai, C., Yokokawa, T., & Ishida, T. (2022). DNA Damage Induced by Radiation Exposure from Cardiac Catheterization An Analysis in Patients and Operators. International Heart Journal, 63(3), 466-475.
- Kılınç, N., Onbaşılar, M., & Çayır, A. (2022). Evaluation of circulating cell-free nucleic acids in health workers occupationally exposed to ionizing radiation. Environ Sci Pollut Res Int., 29(27), 40543-40549.
- Lee, Y., Kim, Y. J., Choi, Y. J., Lee, J. W., Lee, S., Cho, Y. H., & Chung, H. W. (2015). Radiation-induced changes in DNA methylation and their relationship to chromosome aberrations in nuclear power plant workers. Int J Radiat Biol., 91(2), 142-149.
- Lee, W. J., Bang, Y. J., Cha, E. S., Kim, Y. M., & Cho, S. B. (2021). Lifetime cancer risks from occupational radiation exposure among workers at interventional radiology departments. Int Arch Occup., Environ Health, 94(1), 139-145.
- Lee, W.J., Preston, D.L., Cha, E.S., Ko, S., & Lim, H. (2019). Thyroid cancer risks among medical radiation workers in South Korea, 1996-2015. Environ Health, 18(1), 19.
- Linet, M. S., Kim, K. P., Miller, D. L., Kleinerman, R. A., Simon, S. L., & Berrington de Gonzalez, A. (2010). Historical review of occupational exposures and cancer risks in medical radiation workers. Radiat Res. 74(6), 793-808.
- Liu, G., Zhang, R., Li, Y., Wu, X. Q., Niu, L. M., Liu, Y. Y., & Zhang, X. (2022). Study of Low-Dose Radiation Workers Ionizing Radiation Sensitivity Index and Radiation Dose-Effect Relationship. Health Phys., 123(4), 332-339.
- Luna-Sánchez, S., Del Campo, M. T., Morán, J. V., Fernández, I. M., Checa, F. J. S., & de la Hoz, R. E. (2019). Thyroid Function in Health Care Workers Exposed to Ionizing Radiation. Health Phys., 117(4), 403-407.
- Machi, A. Jr., Moreira Perez, M., Luciano da Veiga, G., Cristiano Pereira, E., Adami, F., Alves, B., & Fonseca, F. (2022). Expression of DNA repair genes in association with ionizing radiation. Acta Biomed., 93(3), e2022232.
- Mavragani, I. V., Nikitaki, Z., Kalospyros, S. A., & Georgakilas, A. G. (2019). Ionizing radiation and complex DNA damage: from prediction to detection challenges and biological significance. Cancers, 11(11), 1789.
- McNamara, M. E., Loyfer, N., Kiliti, A. J., Schmidt, M. O., Shabi-Porat, S., Jain, S. S., & Wellstein, A. (2023). Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment. JCI insight, 8(14), e156529.
- Miller, R. B. (2006). Electronic irradiation of foods: an introduction to the technology. Springer Science & Business Media.
- Mladenova, V., Mladenov, E., Stuschke, M. & Iliakis, G. (2022). DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin Breaks. Molecules, 27(5), 1540. DOI: 10.3390/molecules27051540.
- Pillai, S. D., Shayanfar, S. (2017). Electron Beam Technology and Other Irradiation Technology Applications in the Food Industry. Top Curr Chem (Cham), 375(1), 6.
- Popović-Bijelić, A., Mojović, M., Stamenković, S., Jovanović, M., Selaković, V., Andjus, P., & Bačić, G. (2016). Iron-sulfur cluster damage by the superoxide radical in neural tissues of the SOD1G93A ALS rat model. Free Radical Biology and Medicine, 96, 313-322.
- Reisz, J. A., Bansal, N., Qian, J., Zhao, W., & Furdui, C. M. (2014). Effects of ionizing radiation on biological molecules—mechanisms of damage and emerging methods of detection. Antioxidants & redox signaling, 21(2), 260-292.
- Safak, G., Celiker, M., Tümkaya, L., Mercantepe, T., Rakici, S., Cinar, S., & Dursun, E. (2022). Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage. Radiation and Environmental Biophysics, 61(2), 241-253.
- Tahergorabi, R., Matak, K. E., & Jaczynski, J. (2012). Application of electron beam to inactivate Salmonella in food: Recent developments. Food Research International, 45(2), 685-694.
- Wang, F. R., Fang, Q. Q., Tang, W. M., Xu, X. S., Mahapatra, T., Mahapatra, S., Liu, Y. F., Yu, N. L., & Sun, Q. F. (2015). Nested Case-control Study of Occupational Radiation Exposure and Breast and Esophagus Cancer Risk among Medical Diagnostic X Ray Workers in Jiangsu of China. Asian Pac J Cancer Prev, 16(11), 4699-4704.
- Yang, Y., Wang, Q., Yang, L. T., & Zhao, Z. X. (2022). Investigate the thyroid function of radiation workers and analysis of influence factors. Zhonghua lao Dong wei Sheng zhi ye Bing za zhi= Zhonghua Laodong Weisheng Zhiyebing Zazhi= Chinese Journal of Industrial Hygiene and Occupational Diseases, 40(2), 113-116.
- Zhang, Y., Fu, Q., Huang, T., Liu, Y., Chen, G., & Lin, S. (2022). Ionizing radiation-induced DNA damage responses affect cell compressibility. Biochemical and Biophysical Research Communications, 603, 116-122.
- Zhou, Y. J., Tang, Y., Liu, S. J., Zeng, P. H., Qu, L., Jing, Q. C., & Yin, W. J. (2023). Radiation-induced liver disease: beyond DNA damage. Cell Cycle, 22(5), 506-526.
- Zhu, X. J., Du, Q. Q., Lu, Z. H., Yuan, K. K., & Yang, H. Z. (2018). Analysis of individual dose monitoring results among radiation workers in a first-class hospital at Grade 3 from 2010 to 2017. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 36(11), 827-829.
THE EFFECT OF IONIZING RADIATION ON HEALTH PROFESSIONALS WORKING IN THE RADIOLOGY DEPARTMENT
Yıl 2023,
Cilt: 5 Sayı: 3, 129 - 134, 31.12.2023
Adem Keskin
,
Recai Aci
,
Murat Arı
Öz
This study was designed on the effects of radiation on healthcare professionals working in environments with radiation in the healthcare field. Healthcare workers working in radiation areas are exposed to low doses of radiation. The organ most affected by this exposure is the thyroid. There is a significant relationship between thyroid stimulating hormone levels and exposure to radiation for 5 years. People exposed to radiation may develop DNA damage and the DNA repair system may be affected. It can be said that health workers working in the fields of radiation are at risk for some types of cancer depending on the dose they are exposed to. Interventional radiology and nuclear medicine workers are most affected by these harmful effects. In order to be protected from these health problems or to experience less health problems, health workers working in the fields of radiation should apply all kinds of protection methods. These prevention methods should be evaluated both individually and in terms of the patient. In addition, other health professionals should make use of the radiation environment, which is an indispensable element in health, as little as possible. Exposure to radiation during diagnosis or treatment can cause delays in the healing process.
Kaynakça
- Ahmed, M., & Ahmed, R. (2022). Radiation in gastroenterology. Gastroenterology Research, 15(6), 285.
- Azzam, E. I., Jay-Gerin, J. P., & Pain, D. (2012). Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett., 327(1-2), 48-60.
- Boice, J. D., Jr., Ellis, E. D., Golden, A. P., Zablotska, L. B., Mumma, M. T., & Cohen, S. S. (2022). Sex-specific lung cancer risk among radiation workers in the million-person study and patients TB-Fluoroscopy. Int J Radiat Biol., 98(4), 769-780.
- Chartier, H., Fassier, P., Leuraud, K., Jacob, S., Baudin, C., Laurier, D., & Bernier, M. O. (2020). Occupational low-dose irradiation and cancer risk among medical radiation workers. Occup Med (Lond)., 70(7), 476-484.
- Choi, K. H., Ha, M., Lee, W. J., Hwang, S. S., Jeong, M., Jin, Y. W., Kim, H. J., Lee, K. Y., Lee, J. E., Kang, J. W., & Kim, H. (2013). Cancer risk in diagnostic radiation workers in Korea from 1996–2002. Int J Environ Res Public Health., 10(1), 314-327.
- Gaetani ,S., Monaco, F., Bracci, M., Ciarapica, V., Impollonia, G., Valentino, M., Tomasetti, M., Santarelli, L., & Amati, M. (2018). DNA damage response in workers exposed to low-dose ionising radiation. Occup Environ Med., 75(10), 724-729.
- Gbetchedji, A. A., Houndetoungan, G. D., Hounsossou, H. C., Journy, N., Haddy, N., Rubino, C., Biaou, O., Medenou, D., Amoussou-Guenou, K. M., de Vathaire, F., & Allodji, R. S. (2020). A systematic review of occupational radiation individual dose monitoring among healthcare workers exposed in Africa. J Radiol Prot,. 40(4), R141.
- Jin, Y., Yaegashi, D., Shi, L., Ishida, M., Sakai, C., Yokokawa, T., & Ishida, T. (2022). DNA Damage Induced by Radiation Exposure from Cardiac Catheterization An Analysis in Patients and Operators. International Heart Journal, 63(3), 466-475.
- Kılınç, N., Onbaşılar, M., & Çayır, A. (2022). Evaluation of circulating cell-free nucleic acids in health workers occupationally exposed to ionizing radiation. Environ Sci Pollut Res Int., 29(27), 40543-40549.
- Lee, Y., Kim, Y. J., Choi, Y. J., Lee, J. W., Lee, S., Cho, Y. H., & Chung, H. W. (2015). Radiation-induced changes in DNA methylation and their relationship to chromosome aberrations in nuclear power plant workers. Int J Radiat Biol., 91(2), 142-149.
- Lee, W. J., Bang, Y. J., Cha, E. S., Kim, Y. M., & Cho, S. B. (2021). Lifetime cancer risks from occupational radiation exposure among workers at interventional radiology departments. Int Arch Occup., Environ Health, 94(1), 139-145.
- Lee, W.J., Preston, D.L., Cha, E.S., Ko, S., & Lim, H. (2019). Thyroid cancer risks among medical radiation workers in South Korea, 1996-2015. Environ Health, 18(1), 19.
- Linet, M. S., Kim, K. P., Miller, D. L., Kleinerman, R. A., Simon, S. L., & Berrington de Gonzalez, A. (2010). Historical review of occupational exposures and cancer risks in medical radiation workers. Radiat Res. 74(6), 793-808.
- Liu, G., Zhang, R., Li, Y., Wu, X. Q., Niu, L. M., Liu, Y. Y., & Zhang, X. (2022). Study of Low-Dose Radiation Workers Ionizing Radiation Sensitivity Index and Radiation Dose-Effect Relationship. Health Phys., 123(4), 332-339.
- Luna-Sánchez, S., Del Campo, M. T., Morán, J. V., Fernández, I. M., Checa, F. J. S., & de la Hoz, R. E. (2019). Thyroid Function in Health Care Workers Exposed to Ionizing Radiation. Health Phys., 117(4), 403-407.
- Machi, A. Jr., Moreira Perez, M., Luciano da Veiga, G., Cristiano Pereira, E., Adami, F., Alves, B., & Fonseca, F. (2022). Expression of DNA repair genes in association with ionizing radiation. Acta Biomed., 93(3), e2022232.
- Mavragani, I. V., Nikitaki, Z., Kalospyros, S. A., & Georgakilas, A. G. (2019). Ionizing radiation and complex DNA damage: from prediction to detection challenges and biological significance. Cancers, 11(11), 1789.
- McNamara, M. E., Loyfer, N., Kiliti, A. J., Schmidt, M. O., Shabi-Porat, S., Jain, S. S., & Wellstein, A. (2023). Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment. JCI insight, 8(14), e156529.
- Miller, R. B. (2006). Electronic irradiation of foods: an introduction to the technology. Springer Science & Business Media.
- Mladenova, V., Mladenov, E., Stuschke, M. & Iliakis, G. (2022). DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin Breaks. Molecules, 27(5), 1540. DOI: 10.3390/molecules27051540.
- Pillai, S. D., Shayanfar, S. (2017). Electron Beam Technology and Other Irradiation Technology Applications in the Food Industry. Top Curr Chem (Cham), 375(1), 6.
- Popović-Bijelić, A., Mojović, M., Stamenković, S., Jovanović, M., Selaković, V., Andjus, P., & Bačić, G. (2016). Iron-sulfur cluster damage by the superoxide radical in neural tissues of the SOD1G93A ALS rat model. Free Radical Biology and Medicine, 96, 313-322.
- Reisz, J. A., Bansal, N., Qian, J., Zhao, W., & Furdui, C. M. (2014). Effects of ionizing radiation on biological molecules—mechanisms of damage and emerging methods of detection. Antioxidants & redox signaling, 21(2), 260-292.
- Safak, G., Celiker, M., Tümkaya, L., Mercantepe, T., Rakici, S., Cinar, S., & Dursun, E. (2022). Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage. Radiation and Environmental Biophysics, 61(2), 241-253.
- Tahergorabi, R., Matak, K. E., & Jaczynski, J. (2012). Application of electron beam to inactivate Salmonella in food: Recent developments. Food Research International, 45(2), 685-694.
- Wang, F. R., Fang, Q. Q., Tang, W. M., Xu, X. S., Mahapatra, T., Mahapatra, S., Liu, Y. F., Yu, N. L., & Sun, Q. F. (2015). Nested Case-control Study of Occupational Radiation Exposure and Breast and Esophagus Cancer Risk among Medical Diagnostic X Ray Workers in Jiangsu of China. Asian Pac J Cancer Prev, 16(11), 4699-4704.
- Yang, Y., Wang, Q., Yang, L. T., & Zhao, Z. X. (2022). Investigate the thyroid function of radiation workers and analysis of influence factors. Zhonghua lao Dong wei Sheng zhi ye Bing za zhi= Zhonghua Laodong Weisheng Zhiyebing Zazhi= Chinese Journal of Industrial Hygiene and Occupational Diseases, 40(2), 113-116.
- Zhang, Y., Fu, Q., Huang, T., Liu, Y., Chen, G., & Lin, S. (2022). Ionizing radiation-induced DNA damage responses affect cell compressibility. Biochemical and Biophysical Research Communications, 603, 116-122.
- Zhou, Y. J., Tang, Y., Liu, S. J., Zeng, P. H., Qu, L., Jing, Q. C., & Yin, W. J. (2023). Radiation-induced liver disease: beyond DNA damage. Cell Cycle, 22(5), 506-526.
- Zhu, X. J., Du, Q. Q., Lu, Z. H., Yuan, K. K., & Yang, H. Z. (2018). Analysis of individual dose monitoring results among radiation workers in a first-class hospital at Grade 3 from 2010 to 2017. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 36(11), 827-829.