COVID-19 Hastalarının Tanı, Tedavi ve Takibinde Klinik Biyokimya Laboratuvarlarının Rolü

Yıl 2022, , 1 - 9, 31.03.2022

Tuğba Polat , Gülçin Dağlıoğlu , Ozl Gorur , Tamer Cevat İnal

https://doi.org/10.17827/aktd.1000224

Öz

Dünya sağlık örgütü tarafından COVID-19’un pandemi olarak ilan edildiği 11 Mart 2020’den bu yana vaka sayıları tüm dünyada giderek artmış olup bu kontrolsüz artış sağlık sistemleri üzerinde büyük bir yük oluşturmuştur. Tüm dünyada hastalığın yayılımını önlemek amacıyla milyarlarca insan için karantina gibi sert önlemler alınmıştır. Bu da özellikle ülkelerin ekonomi ve sağlık sistemlerini olumsuz etkilemiştir ve etkilemeye de devam etmektedir. Özellikle, asemptomatik COVID-19 vaka oranlarının yüksek olması nedeniyle alınan önlemler yetersiz kalmakta ve pandemi ile mücadeleyi zorlaştırmaktadır. Nükleik asit amplifikasyon testi, SARS-CoV-2 enfeksiyonunun tanısında altın standart yöntemdir. Ancak sonuç verme süresinin uzun olması, %40’a varan yanlış negatiflik oranı nedeniyle hastaların hızlı şekilde taranması, tedaviye başlanması gecikmektedir. Erken dönemde hastaların biyokimyasal testler ile değerlendirilerek tanı ve tedavilerinin hızlandırılması hem hastalığın erken dönem kontrolü açısından hem de salgının yayılımının kontrolü ile salgın sırasında kaynakların doğru ve verimli kullanılması açısından önem taşımaktadır.
Bu derleme ile; hastalığın tanısında, takibinde, hasta için uygun tedavinin düzenlenmesinde kullanılan biyokimyasal testler ile hastalığın prognozunun belirlenmesine yönelik oluşturulan risk tahmin skorlarında kullanılan biyokimyasal testlerin özetlenmesi amaçlanmıştır.

Anahtar Kelimeler

Pandemi, Covid-19, Biyokimyasal testler, SARS-CoV-2

The Role of Clinical Biochemistry Laboratories in the Diagnosis, Treatment and Follow-Up of COVID-19 Patients

Öz

Since 11 March 2020, when COVID-19 was declared as a pandemic by the World Health Organization, the number of cases has increased all over the world and this uncontrolled increase has created a great burden on health systems. Strict measures such as quarantine have been taken for billions of people all over the world to prevent the spread of the disease. This, in particular, has adversely affected the economy and health systems of countries and continues to do so. In particular, due to the high rates of asymptomatic COVID-19 cases, the measures taken remain insufficient and make it difficult to combat the pandemic. Nucleic acid amplification test is the gold standard method in the diagnosis of SARS-CoV-2 infection. However, due to the long duration of giving results and the false negativity rate of up to 40%, the rapid screening of the patients and the initiation of treatment are delayed. Accelerating the diagnosis and treatment of patients by evaluating them with biochemical tests in the early period is important both in terms of early control of the disease and control of the spread of the epidemic and the correct and efficient use of resources during the epidemic.
With this review; it is aimed to summarize the biochemical tests used in the diagnosis, follow-up of the disease, in the regulation of appropriate treatment for the patient, and the biochemical tests used in the risk prediction scores created to determine the prognosis of the disease.

Anahtar Kelimeler

Pandemic, Covıd-19, Biochemical tests, SARS-CoV-2., Pandemic, Covıd-19, Biochemical tests, SARS-CoV-2.

Kaynakça

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