Hidrojen Sülfür’ün Fizyolojik ve Patolojik Olaylara Katkısı ve Klinikte Kullanımı

Kübra Gönbe; Fatma Aydınoğlu; Nuran Öğülener

doi:10.17827/aktd.1066415

TR EN

Hidrojen Sülfür’ün Fizyolojik ve Patolojik Olaylara Katkısı ve Klinikte Kullanımı

Öz

Enzimatik veya non-enzimatik yollarla sentezlenen hidrojen sülfür (H2S), nitrik okside (NO) ve karbonmonoksite (CO) benzer üçüncü bir gaz nörotransmitterdir. Vücutta sentezinden sorumlu enzimler çeşitli dokularda eksprese edilmektedir. Antiinflamatuvar, antiapoptotik, nöroprotektif, gastroprotektif, antispazmotik, sitoprotektif, antioksidan, bronkodilatör, kan basıncı regülasyonu gibi birçok fizyolojik etkisi olan H2S’in, hipertansiyon, ateroskleroz, depresyon, astım, kronik obstrüktif akciğer hastalığı, ülser, erektil disfonksiyon, parkinson ve alzheimer gibi çeşitli patolojik durumlarda da rolü olduğu bilinmektedir. Fizyopatolojik durumlardaki potansiyel önemi göz önüne alınarak H2S salıveren aspirin ve naproksenle kombine çeşitli preperatlar geliştirilmiştir. Bu kapsamda antiinflamatuvar, analjezik, antioksidan, sitoprotektif ve kardiyoprotektif etkiler gösteren bazı aday ilaçlar geliştirilmiştir. ATB-346, GIC-1001, NBS-1120, SG-1002, AP-39 ve MZe76 aday ilaçlar arasında yer almaktadır. S-zofenoprilin isimli ilacın ise faz çalışmaları tamamlanmıştır. L-sistein/H2S yolağıyla ilgili preklinik ve klinik araştırmaların gerçekleştirilmesi fizyolojik, patolojik ve terapötik açıdan önem taşımakta ve bu doğrultuda yeni preperatların geliştirilmesinin tedavi yaklaşımları için umut verici olduğu düşünülmektedir.

Anahtar Kelimeler

Hidrojen sülfür , Gaz nörotransmitter , H2S donörleri

Contribution of Hydrogen Sulfide to Physiological and Pathological Events and Clinical Use

Abstract

Hydrogen sulfide (H2S), synthesized by enzymatic or non-enzymatic means, is a third gas neurotransmitter similar to nitric oxide (NO) and carbon monoxide (CO). Enzymes responsible for their synthesis in the body are expressed in various tissues. H2S has many physiological effects such as anti-inflammatory, antiapoptotic, neuroprotective, gastroprotective, antispasmodic, cytoprotective antioxidant, a bronchodilator, blood pressure regulation. Also, it is known that H2S has a role in various pathological conditions such as hypertension, atherosclerosis, depression, asthma, chronic obstructive pulmonary disease (COPD), ulcer, erectile dysfunction, Alzheimer's, and Parkinson's disease. Considering its potential importance in physiopathological conditions, various drugs have been developed in combination with H2S-releasing aspirin and naproxen. In this context, some drugs with anti-inflammatory, analgesic, antioxidant, cytoprotective, and cardioprotective effects have been developed. ATB-346, GIC-1001, NBS-1120, SG-1002, AP-39, and MZe76 are among the candidate drugs. Phase studies of S-zofenopril have been completed. The realization of preclinical and clinical studies on the L-cysteine/H2S pathway is important physiologically, pathologically, and therapeutically, and the development of new drugs in this direction is considered to be promising for treatment approaches.

Keywords

Hydrogen sulfide , Gas neurotransmitter , H2S donors

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Kübra Gönbe Bu kişi benim
0000-0002-8143-3021
Türkiye

Fatma Aydınoğlu ^*
0000-0003-3691-208X
Türkiye

Nuran Öğülener Bu kişi benim
0000-0002-0716-3422
Türkiye

Yayımlanma Tarihi

30 Haziran 2022

Gönderilme Tarihi

1 Şubat 2022

Kabul Tarihi

12 Mayıs 2022

Yayımlandığı Sayı

Yıl 2022 Cilt: 31 Sayı: 2

DOI

https://doi.org/10.17827/aktd.1066415

IZ

https://izlik.org/JA35NY78CY

AMA

1.Gönbe K, Aydınoğlu F, Öğülener N. Hidrojen Sülfür’ün Fizyolojik ve Patolojik Olaylara Katkısı ve Klinikte Kullanımı. aktd. 2022;31(2):122-131. doi:10.17827/aktd.1066415

Hidrojen Sülfür’ün Fizyolojik ve Patolojik Olaylara Katkısı ve Klinikte Kullanımı

Öz

Anahtar Kelimeler

Contribution of Hydrogen Sulfide to Physiological and Pathological Events and Clinical Use

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster