Kanser Kök Hücrelerine Güncel Yaklaşım

Tuğçe Sapmaz Erçakallı; Sait Polat

doi:10.17827/aktd.1088310

EN TR

Current Approach to Cancer Stem Cells

Öz

Cancer Stem Cells (CSC) are cells that are capable of self-renewal and differentiation, such as normal stem cells and are found in many tissues such as breast, brain, lung, prostate, testis, ovary, esophagus, colon, liver. Their origins have not yet been discovered, but a number of hypotheses have been put forward. CSCs are cells that drive tumorigenesis, as well as give rise to a large population of differentiated progeny that make up the bulk of the tumor. Each cancer has biomarkers that identify the stem cell. The same specific signaling pathways play a functional role in CSC renewal and differentiation as with normal stem cells, the only difference being that the same signaling pathways are dysregulated in CSCs.
CSCs play a role in not only the creation of cancer, but also in its evolution, metastasis, and recurrence. MicroRNAs and several signaling pathways such as Wnt/β-catenin, Notch and Hedgehog control the properties of CSCs. CSCs are resistant to conventional chemotherapy and radiation treatment and that CSCs are very likely to be the origin of cancer metastasis. CSCs are believed to be an important target for novel anti-cancer drug discovery. Future studies will lead to the development of therapies that target CSCs for the treatment of cancer.

Anahtar Kelimeler

metastasis., Cancer stem cell, cancer stem cell markers, normal stem cell, metastasis.

Kanser Kök Hücrelerine Güncel Yaklaşım

Öz

Kanser Kök Hücreleri (KaKH), normal kök hücreler gibi kendi kendini yenileme ve farklılaşma yeteneğine sahip hücreler olup meme, beyin, akciğer, prostat, testis, over, yemek borusu, kolon, karaciğer gibi birçok dokuda bulunur. Kökenleri henüz keşfedilmemiştir, ancak bu konuda bir dizi hipotez öne sürülmüştür. KaKH tümörün başlangıcından sorumlu ve tümör dokusundaki çok sayıda farklılaşmış hücre topluluğunu oluşturan hücrelerdir. Her bir kanserin kök hücresini tanımlayan biyobelirteçler vardır. KaKH’lerin ve normal kök hücrelerin kendi kendini yenileme ve farklılaşmasında aynı özgü sinyal iletim sistemleri rol oynamaktadır. Fakat KaKH’lerde bu sinyal iletim sistemlerinin düzenlenmesi değişmektedir.
KaKH'leri sadece kanserin yaratılmasında değil, evriminde, metastazında ve geç dönemde yeniden ortaya çıkmasında da rol oynamaktadır. MikroRNA'lar, Wnt/β-catenin, Notch ve Hedgehog gibi sinyal yolaklarından oluşan bir düzenleme ağı KaKH özelliklerini kontrol eder. KaKH'leri kanser tedavisinde, konvansiyonel kemoterapi ve radyasyon tedavisine karşı dirençte rol oynarak, kanser metastazının kökeni olarak değerlendirilebilir. KaKH'leri yeni kanser önleyici ilaç keşfi için tedavi protokollerinde hedef haline gelmiştir. Gelecekteki çalışmalar kanserin tedavisi için KaKH’leri hedef alan tedavilerin geliştirilmesine öncülük edecektir.

Anahtar Kelimeler

Kanser Kök Hücresi, Kanser kök hücresi belirteçleri, Normal kök hücre, Metastaz

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Tuğçe Sapmaz Erçakallı ^*
0000-0001-6927-3582
Türkiye

Sait Polat
0000-0003-1646-8831
Türkiye

Yayımlanma Tarihi

30 Haziran 2022

Gönderilme Tarihi

15 Mart 2022

Kabul Tarihi

11 Nisan 2022

Yayımlandığı Sayı

Yıl 2022 Cilt: 31 Sayı: 2

DOI

https://doi.org/10.17827/aktd.1088310

IZ

https://izlik.org/JA96GM75PG

APA

Sapmaz Erçakallı, T., & Polat, S. (2022). Kanser Kök Hücrelerine Güncel Yaklaşım. Arşiv Kaynak Tarama Dergisi, 31(2), 111-121. https://doi.org/10.17827/aktd.1088310

AMA

1.Sapmaz Erçakallı T, Polat S. Kanser Kök Hücrelerine Güncel Yaklaşım. aktd. 2022;31(2):111-121. doi:10.17827/aktd.1088310

Chicago

Sapmaz Erçakallı, Tuğçe, ve Sait Polat. 2022. “Kanser Kök Hücrelerine Güncel Yaklaşım”. Arşiv Kaynak Tarama Dergisi 31 (2): 111-21. https://doi.org/10.17827/aktd.1088310.

EndNote

Sapmaz Erçakallı T, Polat S (01 Haziran 2022) Kanser Kök Hücrelerine Güncel Yaklaşım. Arşiv Kaynak Tarama Dergisi 31 2 111–121.

IEEE

[1]T. Sapmaz Erçakallı ve S. Polat, “Kanser Kök Hücrelerine Güncel Yaklaşım”, aktd, c. 31, sy 2, ss. 111–121, Haz. 2022, doi: 10.17827/aktd.1088310.

ISNAD

Sapmaz Erçakallı, Tuğçe - Polat, Sait. “Kanser Kök Hücrelerine Güncel Yaklaşım”. Arşiv Kaynak Tarama Dergisi 31/2 (01 Haziran 2022): 111-121. https://doi.org/10.17827/aktd.1088310.

JAMA

1.Sapmaz Erçakallı T, Polat S. Kanser Kök Hücrelerine Güncel Yaklaşım. aktd. 2022;31:111–121.

MLA

Sapmaz Erçakallı, Tuğçe, ve Sait Polat. “Kanser Kök Hücrelerine Güncel Yaklaşım”. Arşiv Kaynak Tarama Dergisi, c. 31, sy 2, Haziran 2022, ss. 111-2, doi:10.17827/aktd.1088310.

Vancouver

1.Tuğçe Sapmaz Erçakallı, Sait Polat. Kanser Kök Hücrelerine Güncel Yaklaşım. aktd. 01 Haziran 2022;31(2):111-2. doi:10.17827/aktd.1088310

Current Approach to Cancer Stem Cells

Öz

Anahtar Kelimeler

Kanser Kök Hücrelerine Güncel Yaklaşım

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster