Kanser Tedavisi İçin MikroRNA’ların Çok İşlevli Nano-taşıyıcılar İle Dağıtımı

Yeşim Dağlıoğlu; Aleyna Yüksel

doi:10.17827/aktd.1181394

Kanser Tedavisi İçin MikroRNA’ların Çok İşlevli Nano-taşıyıcılar İle Dağıtımı

Öz

Hücre proliferasyonu ve apoptozis gibi kanserden sorumlu biyolojik süreçlerde etkili olan miRNA’lar, farklı kanser türleri ve evrelerinin teşhis ve tedavisinde yeni biyobelirteçler olarak işlev görür. Bunun yanı sıra bazı miRNA’ların onkogen ve tümör baskılayıcı özelliği nanoteknoloji ile entegre edilmesiyle kanser oluşumunu engeller. Son yıllarda miRNA’ların kanser tedavisinde kullanılmasını sağlayan diğer bir yaklaşım ise nano-taşıyıcılardır. İlaçlar, peptitler veya genler gibi aktif bileşikleri taşımak için geliştirilen bu nano-taşıyıcıların kanser tedavisinde kullanımları umut vadetmektedir. Bu derleme, miRNA dağıtımında kullanılan nano-taşıyıcı türleri hakkında kısa bir bilgi sunmaktadır. Ayrıca nanoteknolojideki gelişmelerle birlikte miRNA’ların kanser teşhis ve tedavisinde kullanımın yanısıra gen susturma mekanizması olan RNA interferansından kısaca bahsedilmektedir.

Anahtar Kelimeler

Kanser , mikroRNA , nano-taşıyıcı , nanoteknoloji , RNA interferansı , Kanser, mikroRNA, nano-taşıyıcı, nanoteknoloji, RNA interferansı

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Yeşim Dağlıoğlu ^*
0000-0001-8740-1162
Türkiye

Aleyna Yüksel
0000-0002-4426-4679
Türkiye

Yayımlanma Tarihi

31 Mart 2023

Gönderilme Tarihi

28 Eylül 2022

Kabul Tarihi

1 Mart 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 32 Sayı: 1

DOI

https://doi.org/10.17827/aktd.1181394

IZ

https://izlik.org/JA88ND22CN

AMA

1.Dağlıoğlu Y, Yüksel A. Kanser Tedavisi İçin MikroRNA’ların Çok İşlevli Nano-taşıyıcılar İle Dağıtımı. aktd. 2023;32(1):52-60. doi:10.17827/aktd.1181394

Kanser Tedavisi İçin MikroRNA’ların Çok İşlevli Nano-taşıyıcılar İle Dağıtımı

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

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Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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