Apigenin'in potansiyel farmakolojik etkileri üzerine bir derleme

Solmaz Susam; Gürkan Çıkım

doi:10.17827/aktd.1267942

Apigenin'in potansiyel farmakolojik etkileri üzerine bir derleme

Öz

Apigenin, günlük hayatta tükettiğimiz meyve ve sebzelerde bolca bulunan, çeşitli sağlık sorunlarının önlenmesinde ve tedavisinde önemli bir rol oynayan flavonoidlerden biridir. Apigeninin, başlıca anti-oksidan, anti-inflamatuvar ve anti-neoplastik olmak üzere çeşitli farmokolojik etkileri bulunmakla birlikte, bu etkilerini spesifik yolaklardaki proteinleri up ya da down regüle ederek sergilemektedir. Bu çalışmada apigeninin özellikle inflamasyon, oksidan-antioksidan denge, kanser, apoptozis ve hücre döngüsü üzerine etkilerine odaklanılmış ve bu özellikleri in vivo ve in vitro çalışmalarla desteklenmiştir. Yapılan araştırmalar neticesinde apigeninin anti-inflamatuvar, anti-oksidan ve anti-kanserojen özellikler sergilediği neticesine varılmıştır. Bununla birlikte apigeninin hasar görmüş, yıpranmış ya da kanseröz hale dönüşmüş hücreleri apoptozise yönlendirdiği, hücre döngüsünü çeşitli kontrol noktalarında durdurarak bu tür hücrelerin çoğalmasını engellediği ve bu şekilde antiproliferatif etki sergilediği gözlenmiştir.

Anahtar Kelimeler

apigenin , inflamasyon , antioksidan , kanser önleme , apoptozis.

Kaynakça

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