X Kromozomu İnaktivasyonu ve İnaktivasyondan Kaçış

Başak Günaştı

doi:10.17827/aktd.1319050

X Kromozomu İnaktivasyonu ve İnaktivasyondan Kaçış

Öz

X kromozomunun inaktivasyonu dişi memelilerde iki tane olan X kromozomlarından bir tanesinin inaktive edilmesidir. İnaktivasyona uğrayacak X kromozomu, heterokromatin şeklinde paketlenmektedir. Böylece bu X kromozomunun üzerindeki genlerin eksprese edilmeleri önlenmektedir. İnaktivasyon işlemi, bir adet X kromozomu bulunan erkekler ile iki adet X kromozomu bulunan dişiler arasındaki dengeyi sağlamaktadır. X kromozomu inaktivasyonu, inaktive edilecek tüm X kromozomunda gerçekleştiği düşünülse de, X kromozomunun üzerindeki genlerin tamamı inaktivasyona maruz kalmayıp bir kısmı inaktivasyondan kaçmaktadır. İnsanlarda X kromozomundan kodlanan genlerin yaklaşık %12 ile 20'si kadarı inaktivasyon işleminden kaçarak eksprese olabilmektedir. Derlemede, X inaktivasyonunun mekanizmaları ele alınarak, aktivasyon sürecini ve aktivasyondan kaçan genleri inceleyeceğiz.

Anahtar Kelimeler

X kromozomu , X inaktivasyonu , Dozaj telafisi

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Hizmetleri ve Sistemleri (Diğer)

Bölüm

Derleme

Yazarlar

Başak Günaştı ^*
0000-0003-3068-0652
Türkiye

Erken Görünüm Tarihi

27 Eylül 2023

Yayımlanma Tarihi

30 Eylül 2023

Gönderilme Tarihi

23 Haziran 2023

Kabul Tarihi

1 Eylül 2023

Yayımlandığı Sayı

Yıl 1970 Cilt: 32 Sayı: 3

DOI

https://doi.org/10.17827/aktd.1319050

IZ

https://izlik.org/JA36PB47YE

AMA

1.Günaştı B. X Kromozomu İnaktivasyonu ve İnaktivasyondan Kaçış. aktd. 2023;32(3):180-187. doi:10.17827/aktd.1319050

X Kromozomu İnaktivasyonu ve İnaktivasyondan Kaçış

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Erken Görünüm Tarihi

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster