Menenjiyomlar: Patogenezden Tedaviye- Güncel Perspektifler ve Bütünsel Bir İnceleme

Yıl 2026, Cilt: 35 Sayı: 1, 1 - 9, 02.03.2026

Özüm Atasoy

https://doi.org/10.17827/aktd.1534133

https://izlik.org/JA58YX36CK

Öz

Menenjiyomlar, en sık görülen primer santral sinir sistemi tümörleridir. İyi huylu ve yavaş büyüyen neoplazmlardır. İyi huylu olmalarına rağmen, bulundukları yere bağlı olarak semptomlara ve morbiditeye neden olabilirler. Moleküler belirteçler, 2021 Dünya Sağlık Örgütü'nün MSS tümörleri sınıflandırmasında önem kazanmıştır ve menenjiyomların derecelendirilmesini desteklemek için spesifik moleküler biyobelirteçler önerilmiştir. Cerrahi, histopatolojik tiplendirme ve derecelendirme için doku sağlayan standart tedavidir. Radyoterapi, ameliyat edilemeyen veya tamamen çıkarılamayan menenjiyomlar için bir alternatiftir. Tamamen çıkarılmış grad 1 menenjiyomlar için radyoterapi önerilmezken, 2. veya 3. grad menenjiyomlu hastalar için adjuvan radyoterapi önerilir. Bu derlemede, WHO 2021 sınıflandırma güncellemelerini takiben menenjiyomların epidemiyolojisi, etiyolojisi, risk faktörleri, tedavisi ve radyoterapinin tedavi yaklaşımındaki rolünü inceledik.

Anahtar Kelimeler

radyoterapi , menenjiyom , stereotaktik radyoterapi , radyocerrahi , beyin tümörleri

Meningiomas: From Pathogenesis to Therapeutics-Current Perspectives and a Holistic Review

https://izlik.org/JA58YX36CK

Öz

Meningiomas are the most common primary central nervous system tumors. They are benign and slow-growing neoplasms. Although they are benign, they can cause symptoms and morbidity depending on their location. Molecular markers gained importance in the 2021 World Health Organization classification of central nervous system tumors, and specific molecular biomarkers have been suggested to support the grading of meningiomas. Surgery is the standard therapy, providing tissue for histopathological typing and grading. Radiotherapy is an alternative for meningiomas that cannot be operated on or completely resected. Radiotherapy is not recommended for completely resected grade-1 meningiomas, while adjuvant radiotherapy is recommended for patients with grade-2 or grade-3 meningiomas. In this review, we discuss the epidemiology, etiology, risk factors, treatment, and the role of radiotherapy in the treatment approach of meningiomas following the WHO 2021 classification updates.

Anahtar Kelimeler

radiotherapy , meningioma , stereotactic radiotherapy , radiosurgery , brain tumors

Kaynakça

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