Locus Coeruleus: Uyku-Uyanıklık Döngüsünde Nöroanatomik Bir Anahtar

Sena Güldehan Uçan

doi:10.17827/aktd.1730487

TR EN

Locus Coeruleus: Uyku-Uyanıklık Döngüsünde Nöroanatomik Bir Anahtar

Öz

Locus coeruleus, beyin sapında bulunan ve merkezi noradrenerjik sistemin temel kaynağını teşkil eden bir çekirdek olarak tanımlanmaktadır. Geniş afferent ve efferent projeksiyonları sayesinde kortikal ve subkortikal birçok alanla bağlantı kuran bu yapı; uyku-uyanıklıktan dikkat, bellek konsolidasyonu ve duygusal düzenlemeye kadar geniş bir nörofizyolojik spektrumda işlev görmektedir. Bu derleme, locus coeruleusun özellikle uyku-uyanıklık döngüsündeki rolünü vurgulayarak anatomik ve kimyasal özellikleri ile hızlı göz hareketi (rapid eye movement-REM) ve hızlı göz hareketi olmayan (non-rapid eye movement- NREM) uyku evreleri boyunca sergilediği aktivite değişimlerini incelemektedir. Homeostatik ve sirkadiyen uyku düzenleyici sistemlerle etkileşimi, uykunun başlatılması, sürdürülmesi ve geçiş evrelerindeki spesifik katkıları vurgulanmaktadır. Ek olarak, disfonksiyonunun çeşitli uyku bozukluklarıyla olan ilişkisi ele alınmaktadır. Bu çalışma, literatürdeki mevcut bilgileri bütüncül bir yaklaşımla sentezleyerek locus coeruleusun uyku fizyolojisindeki merkezi rolünü daha iyi anlamaya yönelik kavramsal bir çerçeve sunmayı hedeflemektedir.

Anahtar Kelimeler

uyku , locus coeruleus , uyku bozuklukları

Locus Coeruleus: A Neuroanatomical Key in the Sleep-Wake Cycle

Abstract

The locus coeruleus is defined as a nucleus located in the brainstem that constitutes the primary source of the central noradrenergic system. Through its extensive afferent and efferent projections connecting with numerous cortical and subcortical regions, this structure functions across a wide neurophysiological spectrum, ranging from sleep-wake regulation to attention, memory consolidation, and emotional modulation. This review emphasizes the role of the locus coeruleus particularly in the sleep-wake cycle by examining its anatomical and chemical characteristics alongside the variations in its activity during rapid eye movement (REM) and non-rapid eye movement (NREM) sleep stages. Its interaction with homeostatic and circadian sleep regulatory systems, along with its specific contributions to sleep initiation, maintenance, and transitional phases, are highlighted. Additionally, the relationship between locus coeruleus dysfunction and various sleep disorders is discussed. This study aims to provide a conceptual framework that synthesizes current literature in a comprehensive manner to better understand the central role of the locus coeruleus in sleep physiology.

Keywords

sleep , locus coeruleus , sleep disturbances

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sinirbilim (Diğer)

Bölüm

Derleme

Yazarlar

Sena Güldehan Uçan ^*
0009-0006-6754-2295
Türkiye

Yayımlanma Tarihi

2 Mart 2026

Gönderilme Tarihi

30 Haziran 2025

Kabul Tarihi

11 Şubat 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 35 Sayı: 1

DOI

https://doi.org/10.17827/aktd.1730487

IZ

https://izlik.org/JA72BL66XC

AMA

1.Uçan SG. Locus Coeruleus: Uyku-Uyanıklık Döngüsünde Nöroanatomik Bir Anahtar. aktd. 2026;35(1):64-71. doi:10.17827/aktd.1730487

Locus Coeruleus: Uyku-Uyanıklık Döngüsünde Nöroanatomik Bir Anahtar

Öz

Anahtar Kelimeler

Locus Coeruleus: A Neuroanatomical Key in the Sleep-Wake Cycle

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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