Derleme

Perinatal Transmission of Hepatitis B Virus

Cilt: 25 Sayı: 3 30 Eylül 2016
Murat Afyon , Cumhur Artuk
PDF İndir
TR EN

Perinatal Transmission of Hepatitis B Virus

Abstract

Perinatal transmission of hepatitis B virus (HBV) is the predominant mode of transmission in countries with a high prevalence of hepatitis B surface antigen carriage. Perinatal transmission can occur via three modalities: intrauterine transmission; transmission during delivery; and postpartum transmission and perinatal transmission results in a high frequency of chronic infection. Therefore, it is important to prevent perinatal transmission. At-birth prophylaxis with hepatitis B immunoglobulin (HBIG) and the first dose of the HBV vaccine can prevent transmission during delivery or in the postpartum period, but it has no effect on the intrauterine route of transmission. Due to the residual risk of perinatal transmission despite correct use of birth prophylaxis with HBIG and vaccine, other strategies (namely, antiviral drugs, HBIG to the mother, and mode of delivery) have been tested in several studies.  

Keywords

Pregnancy,hepatitis B virus,perinatal transmission,antiviral prophylaxis

Kaynakça

  1. World Health Organization (WHO). 2014. Hepatitis B Fact Sheet 2014. http://www.who.int/ mediacentre/factsheets/fs204/en. (accessed Dec 2, 2015).
  2. Mıstık R, Balık İ. Türkiye’de viral hepatitlerin epidemiyolojik analizi. In Viral Hepatit Kitabı 2001 (Eds K Kılıçturgay, S Badur):10-55. İstanbul, Viral Hepatitle Savaşım Derneği, 2001.
  3. Bolat AD, Akın FE, Yürekli ÖT. Gebelikte hepatit B virus enfeksiyonu-anneden bebeğe geçişte etkili risk faktörleri ve yönetimi. Journal of Clinical Analytical Medicine. 2015;62:262-7.
  4. Liu CP, Zeng YL, Zhou M, Chen LL, Hu R, Wang L et al. Factors associated with mother-to-child transmission of hepatitis B virus despite immunoprophylaxis. Intern Med. 2015;54:711-6.
  5. Gentile I, Borgia G. Vertical transmission of hepatitis B virus: challenges and solutions. Int J Womens Health. 2014;10:605-11.
  6. Chen T, Wang J, Feng Y, Yan Z, Zhang T, Liu M et al. Dynamic changes of HBV markers and HBV DNA load in infants born to HBsAg (+) mothers: Can positivity of HBsAg or HBV DNA at birth be an indicator for HBV infection of infants? BMC Infect Dis. 2013;6:524.
  7. Wang JS, Chen H, Zhu QR. Transformation of hepatitis B serologic markers in babies born to hepatitis B surface antigen positive mothers. World J Gastroenterol. 2005;11:3582–5.
  8. Ahmed MM, Huang TH, Xie QD. A sensitive and rapid assay for investigating vertical transmission of hepatitis B virus via male germ line using EGFP Vector as reporter. J Biomed Biotechnol. 2008;2008:495436.
  9. Bai GQ, Li SH, Yue YF, Shi L. The study on role of peripheral blood mononuclear cell in HBV intrauterine infection. Arch Gynecol Obstet. 2011;283:317–21.
  10. Xu DZ, Yan YP, Choi BC, Xu JQ, Men K, Zhang JX et al. Risk factors and mechanism of trans- placental transmission of hepatitis B virus: a case-control study. J Med Virol. 2002;67:20–6.

Kaynak Göster

AMA
1.Afyon M, Artuk C. Perinatal Transmission of Hepatitis B Virus. aktd. 2016;25(3):304-318. doi:10.17827/aktd.237672