Genetics and Epigenetics of Alzheimer Disease
Öz
Alzheimer’s disease is the most common cause of dementia in elderly. Alzheimer’s disease the role of genetics in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) are responsible for early-onset autosomal dominant Alzheimer disease. For the more common complex late-onset Alzheimer disease, the 3 allele of the gene encoding apolipoprotein E (APOE ) has been recognized as a major genetic risk factor. Alzheimer’s disease is a complex neurodegenerative disorder involving dysregulation of many biological pathways at multiple levels. Epigenetic changes, including DNA methylation and histone modifications are among the major regulatory elements that control these pathways.
Anahtar Kelimeler
Kaynakça
- 1. Keller L. Genetics in Dementia. Phd Thesis, Karolinska Institutet, The Sweden. 2010.
- 2. Erişim: (http://www.bilimvesaglik.com/norolojik-hastaliklar/norodejeneratif-hastaliklar-nelerdir.html) Erişim tarihi: 10.09.2014
- 3. Alonso Vilatela ME, López-López M, Yescas-Gómez P. Genetics of Alzheimer's disease. Arch Med Res. 2012;43:31-622
- 4. Goedert M, Spillantini MG. A century of Alzheimer's disease. Science. 2006;81-777.
- 5. Bekris LM, Yu CE, Bird TD, Tsuang DW. Genetics of Alzheimer disease. J Geriatr Psychiatry Neurol. 2010;27-213.
- 6. Ridge PG, Ebbert MT, Kauwe JS. Genetics of Alzheimer's disease. Biomed Res Int. 2013;254954.
- 7. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer's disease. Alzheimers Dement. 2007;3:91-186.
