Genetics and Epigenetics of Alzheimer Disease
Abstract
Alzheimer’s disease is the most common cause of dementia in elderly. Alzheimer’s disease the role of genetics in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) are responsible for early-onset autosomal dominant Alzheimer disease. For the more common complex late-onset Alzheimer disease, the 3 allele of the gene encoding apolipoprotein E (APOE ) has been recognized as a major genetic risk factor. Alzheimer’s disease is a complex neurodegenerative disorder involving dysregulation of many biological pathways at multiple levels. Epigenetic changes, including DNA methylation and histone modifications are among the major regulatory elements that control these pathways.
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Kaynakça
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