Relationship between Epigenetics and Circadian Clock
Abstract
The circadian clock controls the daily rhythmicity of the biochemistry, physiology, and behavior of the organisms. Disruption of circadian rhythms, affects many biological processes within the body and results in different long-term diseases, such as cancer. Circadian regulatory pathways causes rhythmic epigenetic modifications and the formation of circadian epigenomes. Abnormal epigenetic modifications, such as hypermethylation, may be involved in the transformation of normal cells into cancer cells. In this review, some of the circadian genes and regulatory proteins, the current evidence related to the epigenetic modifications that result in circadian disruption and he carcinogenic effects of circadian disruption and its potential role in different human cancers using an epigenetic viewpoint will be reviewed.
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