Matriks Metalloproteinaz Enzim Ailesi
Öz
Matriks metalloproteinazlar, embriyogenezis, doku yeniden yapılandırılması, yara iyileşmesi ve anjiyogenezis gibi pek çok biyolojik süreçte ve ateroskleroz, artrit ve kanser gibi patolojik durumda önemli rol oynamaktadırlar. Bügüne kadar insanlarda, farklı grup matriks metalloproteinaz enzimlerini kodlayan 24 gen tanımlanmıştır. Bu derlemede, matriks metalloproteinaz ailesinin üyeleri, bunların substrat özgüllüğü, yapıları, fonksiyonları ve enzim aktivitelerinin doku inhibitörleri ile düzenlenmesi tartışılmıştır.
Anahtar Kelimeler
Doku inhibitörleri, jelatinaz, kollojenaz, matriks metalloproteinaz
Kaynakça
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