Doğal Öldürücü Hücre Immunglobulin-Benzeri Reseptör Genleri

Özlem Görüroğlu Öztürk

EN TR

Doğal Öldürücü Hücre Immunglobulin-Benzeri Reseptör Genleri

Öz

Doğal öldürücü hücre immünglobulin-benzeri reseptörler (Killer cell immunoglobulin-like receptors, KIR), doğal öldürücü hücrelerin yüzeylerinde eksprese olan ve doğal immünitenin düzenlenmesinde önemli rol oynayan moleküllerdir. KIR’lar 19q13.4 kromozomundaki bir gen demeti tarafından kodlanmaktadır. KIR gen demeti oldukça polimorfiktir, bireysel genler allelik polimorfizm içerirken, bireysel haplotipler gen içeriyi açısından farklılıklar gösterir. Human Lökosit Antijen (HLA) genlerine paralel olan KIR lokusunun polimorfizmleri, immün sistemin dinamik ve gelişen çevreye adaptasyonunu kolaylaştırmaktadır. Bu varyasyon pek çok hastalıkla ilişkilidir. Bu derlemede pek çok hastalıkta ve transplantasyon immünolojisinde önem taşıyan KIR moleküllerinin, biyolojisi ve genetiği konuları ele alınmıştır.

Anahtar Kelimeler

Doğal immunite, HLA, KIR, KIR genleri

Kaynakça

O’Connor GM, Hart OM, Gardiner CM. Putting the natural killer cell in its place. Immunology. 2005;117:1–10.
Deniz G, Erten G, Kucuksezer UC et al. Regulatory NK Cells Suppress Antigen-Specific T Cell Responses The Journal of Immunology. 2008;180: 850–7.
Moretta L, Biassoni R, Bottino C et al. Human NK cells and their receptors. Microbes Infect 2002;4:1539-44.
Warren HS, Campbell AJ, Waldron JC et al. Biphasic response of NK cells expressing both activating and inhibitory killer Ig-like receptors. Int Immunol. 2001;13:1043-52.
Keaney L, Williams F, Meenagh A et al. Investigation of killer cell immunoglobulin-like receptor gene diversity III. KIR2DL3. Tissue Antigens. 2004;64:188-94.
Williams F, Meenagh A, Sleator C et al. Investigation of killer cell immunoglobulin like receptor gene diversity: I. KIR2DL4. Hum Immunol. 2004;65:31-8.
http://www.ebi.ac.uk/ipd/kir/introduction.html. erişim tarihi 29.06.2011
André P, Biassoni R, Colonna M et al. New nomenclature for MHC receptors. Nat Immunol. 2001;2:661.
Middleton D, Williams F, Halfpenny IA. KIR genes. Transplant Immunology. 2005; 14:135–42.
Borrego F, Kabat J, Kim DK et al. Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells. Mol Immunol. 2002;38:63760.

Halfpenny IA, Middleton D, Barnett YA et al. Investigation of killer cell immunoglobulin-like receptor gene diversity: IV. KIR3DL1/S1. Hum Immunol. 2004;65:602-12.
Marsh SG, Parham P, Dupont B et al. Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002. Hum Immunol. 2003;64:648-54.
Uhrberg M, Valiante NM, Shum BP et al. Human diversity in killer cell inhibitory receptor genes. Immunity. 1997;7:753-63.
Khakoo SI, Rajalingam R, Shum BP et al. Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans. Immunity. 2000;12:687-98.
Wilson MJ, Torkar M, Haude A et al. Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci U S A. 2000;97:4778-83.
Trowsdale J. Genetic and functional relationships between MHC and NK receptor genes. Immunity. 2001;15:363-74.
Middleton D, Gonzalez A, Gilmore PM. Studies on the expression of the deleted KIR2DS4*003 gene product and distribution of KIR2DS4 deleted and nondeleted versions in different populations. Hum Immunol. 2007;68:128-34.
Denis L, Sivula J, Gourraud PA et al. Genetic diversity of KIR natural killer cell markers in populations from France, Guadeloupe, Finland, Senegal and Re´ union Tissue Antigens. 2005;66:267–76.
Shilling HG, Young N, Guethlein LA et al. Genetic control of human NK cell repertoire. J Immunol. 2002;169:239-47.
Shilling HG, Guethlein LA, Cheng NW et al. Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype. J Immunol. 2002;168:2307-15.
Jacobs R, Stoll M, Stratmann G et al. CD16- CD56+ natural killer cells after bone marrow transplantation. Blood. 1992;79:3239-44.
Witt CS, Dewing C, Sayer DC et al. Population frequencies and putative haplotypes of the killer cell immunoglobulin-like receptor sequences and evidence for recombination. Transplantation. 1999;68:1784-89.
Maxwell LD, Wallace A, Middleton D et al. A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey. Tissue Antigens. 2002;60:254-58.
Hsu KC, Liu XR, Selvakumar A et al. Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets. J Immunol. 2002;169:5118-29.
Uhrberg M, Parham P, Wernet P. Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes. Immunogenetics. 2002;54:221-9.
Bishara A, Brautbar C, Eid A et al. Killer inhibitory receptor mismatching and liver transplantation outcome. Transplant Proc. 2001;33:2908.
Carrington M, Norman P. The KIR Gene Cluster. U.S. Natl. Library Med., National Center for Biotechnology Information, Bethesda, MD; 2003.
Vilches C, Rajalingam R, Uhrberg M et al. KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains. J Immunol. 2000;164:5797-804.
Gómez-Lozano N, Gardiner CM, Parham P et al. Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B. Immunogenetics. 2002;54:314-19.
Vilches C, Gardiner CM, Parham P. Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene. J Immunol. 2000;165:6416-21.
Norman PJ, Carrington CV, Byng M et al. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun. 2002;3:86-95.
Watzl C, Peterson M, Long EO. Homogenous expression of killer cell immunoglobulin-like receptors (KIR) on polyclonal natural killer cells detected by a monoclonal antibody to KIR2D. Tissue Antigens. 2000;56:240-47.
Moretta L, Moretta A. Killer immunoglobulin-like receptors Current Opinion in Immunology. 2004;16:626–33.
Santaourlidis S, Trompeter HI, Weinhold S et al. Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells. J Immunol. 2002;169:4253-61.
Zambello R, Della Chiesa M, Trentin L et al. Expression and functional and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes (LDGL). Blood. 2003;102:1797-805.
Pando MJ, Gardiner CM, Gleimer M et al. The protein made from a common allele of KIR3DL1 (3DL1*004) is poorly expressed at cell surfaces due to substitution at positions 86 in Ig domain 0 and 182 in Ig domain 1. J Immunol. 2003;171:6640-49.
Middleton D, Menchaca L, Rood H et al. New allele frequency database: http://www.allelefrequencies.net. Tissue Antigens. 2003;61:403-7.
Ozturk OG, Polat G, Atik U. Diversity of killer cell immunoglobulin-like receptor genes in southern Turkey. Molec Biol Rep 2011 May 23 (in press)
Velardi A, Ruggeri L, Alessandro et al. NK cells: a lesson from mismatched hematopoietic transplantation. Trends Immunol. 2002;23:438-44.
Williams AP, Bateman AR, Khakoo SI. Hanging in the balance. KIR and their role in disease. Mol Interv. 2005;5:226-40.
Nowakowski GS, Morice WG, Phyliky RL et al. Human leucocyte antigen class I and killer immunoglobulin-like receptor expression patterns in T-cell large granular lymphocyte leukaemia. Br J Haematol. 2005;128:490-92.
Poszepczynska-Guigné E, Schiavon V, D'Incan M et al. CD158k/KIR3DL2 is a new phenotypic marker of Sezary cells: relevance for the diagnosis and follow-up of Sezary syndrome. J Invest Dermatol. 2004;122:820-23.
López-Vázquez A, Rodrigo L, Martínez-Borra J et al. Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection. J Infect Dis. 2005;192:162-5.
Naumova E, Mihaylova A, Stoitchkov K et al. Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals. Cancer Immunol Immunother. 2005;54:172-8.
Norris S, Doherty DG, Curry M et al. Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy. Cancer Immunol Immunother. 2003;52:53-8.
Ozturk OG, Gun FD, Polat G. Killer cell immunoglobulin-like receptor genes in patients with breast cancer. Med Oncol. 2011 Apr 9 (in press).

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Özlem Görüroğlu Öztürk Bu kişi benim

Yayımlanma Tarihi

1 Eylül 2011

Gönderilme Tarihi

30 Ekim 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2011 Cilt: 20 Sayı: 3

IZ

https://izlik.org/JA38ZE96TB

AMA

1.Öztürk ÖG. Doğal Öldürücü Hücre Immunglobulin-Benzeri Reseptör Genleri. aktd. 2011;20(3):131-144. https://izlik.org/JA38ZE96TB

Doğal Öldürücü Hücre Immunglobulin-Benzeri Reseptör Genleri

Killer Cell Immunoglobulin-Like Receptor Genes

Abstract

Keywords

Doğal Öldürücü Hücre Immunglobulin-Benzeri Reseptör Genleri

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

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