Review of Concepts and Controversies of Uric Acid as Antioxidant and Pro-Oxidant

Amar Nagesh Kumar; Pathiputhuru Aruna; Jupalle Nagaiah Naidu; Robby Kumar; Anuj Kumar Srivastava

doi:10.17827/aktd.53469

EN TR

Review of Concepts and Controversies of Uric Acid as Antioxidant and Pro-Oxidant

Abstract

Uric acid, the end product of purine catabolism in humans and is known for its crystal deposition at
higher concentrations (>7 mg/dl) in gout. Less is known about its antioxidant property and the
beneficial effects in various diseases. It is thought that high concentration of uric acid in humans is an
evolutionary advantage and it is also hypothesized that high concentration of uric acid is to
compensate the antioxidant capacity of ascorbic acid which is lost in humans during the course of
evolution. In the extracelluar environment, uric acid can scavenge free radicals like hydroxyl radical,
singlet oxygen and peroxynitrite radical therefore, it is considered as a powerful antioxidant. On the
other hand uric acid depending upon the chemical milieu, changing its property and at times it acts as
pro oxidant and is associated with the pathobiochemistry in developing various diseases like
hypertension, cardio vascular diseases, ischemia reperfusion injury, diabetes mellitus, non alcoholic
fatty liver disorders etc. In this review, we tried to summarize the evolutionary advantages of
hyperuricaemia, effects of both antioxidant property and pro-oxidant nature of uric acid in various
disease conditions.

Keywords

Hyperuricaemia, antioxidant, pro-oxidant, paradox, beneficial effects of uric acid

Kaynakça

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Correspondence Address / Yazışma Adresi

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Amar Nagesh Kumar Bu kişi benim

Pathiputhuru Aruna Bu kişi benim

Jupalle Nagaiah Naidu Bu kişi benim

Robby Kumar Bu kişi benim

Anuj Kumar Srivastava Bu kişi benim

Yayımlanma Tarihi

17 Kasım 2014

Gönderilme Tarihi

17 Kasım 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 1970 Cilt: 24 Sayı: 1

DOI

https://doi.org/10.17827/aktd.53469

IZ

https://izlik.org/JA56FU27DX

AMA

1.Kumar AN, Aruna P, Naidu JN, Kumar R, Srivastava AK. Review of Concepts and Controversies of Uric Acid as Antioxidant and Pro-Oxidant. aktd. 2014;24(1):19-40. doi:10.17827/aktd.53469

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Ürik Asidin Antioksidan ve Pro-Oksidan Özellikleri ile İlgili Kavram ve Tartışmalarının Derlemesi

Review of Concepts and Controversies of Uric Acid as Antioxidant and Pro-Oxidant

Abstract

Keywords

Ürik Asidin Antioksidan ve Pro-Oksidan Özellikleri ile İlgili Kavram ve Tartışmalarının Derlemesi

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

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Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

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Yayımlandığı Sayı

DOI

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Kaynak Göster

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