A Gene Expression Regulator: miRNA
Abstract
MicroRNAs (miRNA) binding to target mRNAs and having function in regulating gene expression are of 18-25 nucleotides in length and take place in the class of non-coding RNAs. Although aproximately 1900 human miRNA types have been identified so far, quite little is known about their biological functions. In some studies, it is shown that miRNA expression levels are important for many biological functions such as cell proliferation, differentiation, apoptosis and metabolism. Recent studies have pointed out that miRNAs have been used as diagnosis and prognosis biomarker in many human diseases including cancer, viral diseases, cardiovascular disorders and metabolic distrubance.Such as a miRNA type’s regulating more than one mRNA expression levels, a mRNA level has been regulated by numbers of miRNA types. Since changing the expression level of a miRNA type effects the whole metabolism, it is required to have cell-specific miRNAs. In the event of cell type- specific miRNAs are having found, it is expected that the general metabolism is better understood and, moreover, miRNAs are used more effectively in diagnosis and treatment of diseases.
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Kaynakça
- Kaikkonen MU,Lam MT,Glass CK. Non-coding RNAs as regulators of gene expression and epigenetics. Cardiovasc Res. 2011;90:430-40.
- Güzelgül F. Orak hücreli anemilerde miRNA ekspresyon düzeylerinin RT-PCR ile belirlenmesi (Doktora tezi). Adana, Çukurova Üniversitesi, 2014.
- Güzelgül F. Aksoy K. Kodlanmayan RNA’ların işlevi ve tıpta kullanım alanları. Arşiv Kaynak Tarama Dergisi. 2009;18:141-55.
- Almeida MI,Reis RM,Calin GA. MicroRNA history: discovery, recent applications, and next frontiers. http://www.mirbase.org/index.shtml (Accessed: January 2015). Wei F, Yue F. MicroRNAs in neural cell development and brain diseases. Sci China Life Sci. 2011;54:1103-12.
- Bissels U, Bosio A, Wagner W. MicroRNAs are shaping the hematopoietic landscape. Haematologica. 2012;97:160-7.
- Großhans H. Regulation of microRNAs. Eds. New York, Springer Science Business Media, 2010.
- Treiber T, Treiber N, Meister G. Regulation of microRNA biogenesis and function. Tromb Haemotology. 2012;107:605-10.
- Curtis HJ, Sibley CR, Wood MJA. Mirtrons, an emerging class of atypical miRNA. Wiley Interdiscip Rev RNA. 2012; 3:617-32.
- Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004; 23:4051-60.
- Borchert GM,Lanier W,Davidson BL. RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol.2006;13:1097-101.
