Otizm Spektrum Bozukluğuna Moleküler Bakış: Genetik ve İmmünolojik Etmenler ile Bağırsak Mikrobiyotası üzerine Bulgular

Rafig Gurbanov

doi:10.17827/aktd.487677

TR

Otizm Spektrum Bozukluğuna Moleküler Bakış: Genetik ve İmmünolojik Etmenler ile Bağırsak Mikrobiyotası üzerine Bulgular

Öz

Çağımızın giderek artan sorunlarından biri olan otizm spektrum bozukluğu sosyal gelişimde yetersizlik, tekrarlayıcı motor hareketler ve dil gelişiminde gerilik gibi heterojen nörogelişimsel rahatsızlıklar için kullanılan şemsiye bir terimdir. Hastalığın etiyolojisini etkileyen en önemli nedenlerin başında genetik etmenler gelmektedir. Otizmin, çoğu kromozom üzerinde birçok lokus da meydana gelmiş mutasyonlardan etkilendiği kanıtlanmıştır. Hastalığın etiyolojisine katkıda bulunan bir başka etmen ise immün sistemdir. Yapılan çalışmalar immün sistemi oluşturan elemanlardaki değişkenliklerin otizmi yakından etkilediğini göstermiştir. Otizmin kalıtımsal rolü ne kadar güçlü olsa da çevresel etmenlerin sebep olduğu disfonksiyonlar da göz ardı edilmemelidir. Bu bağlamda, bağırsak mikrobiyotasının, otizm ile ilişkili olduğu güncel çalışmalarla kanıtlanmıştır. Ayrıca, bozulmuş bağırsak mikrobiyotanın immün sistemi ve merkezi sinir sistemini etkileyerek otizm benzeri davranışlara sebep olduğu da bilinmektedir. Bu derlemede, bahsedilen etmenler moleküler düzeyde incelenmiş ve probiyotiklerle tedavi seçeneklerinin potansiyelinden bahsedilmiştir.

Anahtar Kelimeler

Otizm Spektrum Bozukluğu,Mikrobiyota,Genetik Etmenler,İmmün Sistem,Probiyotikler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Rafig Gurbanov ^*
0000-0002-5293-6447
Türkiye

Yayımlanma Tarihi

31 Mart 2020

Gönderilme Tarihi

26 Kasım 2018

Kabul Tarihi

13 Haziran 2019

Yayımlandığı Sayı

Yıl 2020 Cilt: 29 Sayı: 1

DOI

https://doi.org/10.17827/aktd.487677

IZ

https://izlik.org/JA39PN74TS

AMA

1.Gurbanov R. Otizm Spektrum Bozukluğuna Moleküler Bakış: Genetik ve İmmünolojik Etmenler ile Bağırsak Mikrobiyotası üzerine Bulgular. aktd. 2020;29(1):8-23. doi:10.17827/aktd.487677

Otizm Spektrum Bozukluğuna Moleküler Bakış: Genetik ve İmmünolojik Etmenler ile Bağırsak Mikrobiyotası üzerine Bulgular

Abstract

Otizm Spektrum Bozukluğuna Moleküler Bakış: Genetik ve İmmünolojik Etmenler ile Bağırsak Mikrobiyotası üzerine Bulgular

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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