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Testis İnişinin Moleküler Mekanizması

Yıl 2021, , 22 - 30, 31.03.2021
https://doi.org/10.17827/aktd.699932

Öz

Erkeklerde spermatogenezin normal şekilde gerçekleşebilmesi için testislerin karın boşluğu dışında, vücuttan 2-3°C düşük sıcaklıkta skrotum adı verilen kese içerisine inmeleri gerekmektedir. Testis iniş mekanizması türler arasında farklılık göstermekle birlikte, testislerin intrabdominal seviyeden skrotuma inmeleri hormonal ve mekanik etkilere bağlı olarak transabdominal ve inguinoskrotal evreler sonunda gerçekleşmektedir. Kranial süspansör ligament dejenerasyonu ve gubernakular şişme reaksiyonu ile karakterize olan transabdominal evre Leydig hücrelerinden salınan INSL3 (İnsülin benzeri faktör-3) kontrolündedir. Testislerin inguinal kanaldan geçerek skrotuma indiği son evre olan inguinoskrotal evre ise androjen bağımlıdır. Testislerin iniş süreci INSL3 ve androjenler dışında, Sertoli hücrelerinden salınan MIS (Mülleryan inhibe edici madde), genitofemoral sinir uçlarından salınan CGRP (Kalsitonin gen-bağımlı peptid), peritoneal bir divertikül olan vaginal prosses, meme hattı altındaki MFP (Meme yağ yastıkçığı) ile Hox genlerinin rol oynadığı kompleks bir süreçtir. Testis iniş mekanizmasında meydana gelen herhangi bir aksaklık durumunda, infertilite ve testiküler kanser nedenleri arasında sayılan anorşi, refraktil testis, kriptorşidizm ve ektopik testis görülebilmektedir.

Kaynakça

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Toplam 54 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Gülfidan Coşkun 0000-0001-8219-2816

Yayımlanma Tarihi 31 Mart 2021
Kabul Tarihi 25 Mart 2021
Yayımlandığı Sayı Yıl 2021

Kaynak Göster

AMA Coşkun G. Testis İnişinin Moleküler Mekanizması. aktd. Mart 2021;30(1):22-30. doi:10.17827/aktd.699932