Testis İnişinin Moleküler Mekanizması

Gülfidan Coşkun

doi:10.17827/aktd.699932

Testis İnişinin Moleküler Mekanizması

Öz

Erkeklerde spermatogenezin normal şekilde gerçekleşebilmesi için testislerin karın boşluğu dışında, vücuttan 2-3°C düşük sıcaklıkta skrotum adı verilen kese içerisine inmeleri gerekmektedir. Testis iniş mekanizması türler arasında farklılık göstermekle birlikte, testislerin intrabdominal seviyeden skrotuma inmeleri hormonal ve mekanik etkilere bağlı olarak transabdominal ve inguinoskrotal evreler sonunda gerçekleşmektedir. Kranial süspansör ligament dejenerasyonu ve gubernakular şişme reaksiyonu ile karakterize olan transabdominal evre Leydig hücrelerinden salınan INSL3 (İnsülin benzeri faktör-3) kontrolündedir. Testislerin inguinal kanaldan geçerek skrotuma indiği son evre olan inguinoskrotal evre ise androjen bağımlıdır. Testislerin iniş süreci INSL3 ve androjenler dışında, Sertoli hücrelerinden salınan MIS (Mülleryan inhibe edici madde), genitofemoral sinir uçlarından salınan CGRP (Kalsitonin gen-bağımlı peptid), peritoneal bir divertikül olan vaginal prosses, meme hattı altındaki MFP (Meme yağ yastıkçığı) ile Hox genlerinin rol oynadığı kompleks bir süreçtir. Testis iniş mekanizmasında meydana gelen herhangi bir aksaklık durumunda, infertilite ve testiküler kanser nedenleri arasında sayılan anorşi, refraktil testis, kriptorşidizm ve ektopik testis görülebilmektedir.

Anahtar Kelimeler

Testis inişi , Transabdominal evre , İnguinoskrotal evre , INSL3 , Androjen

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Gülfidan Coşkun ^*
0000-0001-8219-2816
Türkiye

Yayımlanma Tarihi

31 Mart 2021

Gönderilme Tarihi

6 Mart 2020

Kabul Tarihi

25 Mart 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 30 Sayı: 1

DOI

https://doi.org/10.17827/aktd.699932

IZ

https://izlik.org/JA82TK89DT

AMA

1.Coşkun G. Testis İnişinin Moleküler Mekanizması. aktd. 2021;30(1):22-30. doi:10.17827/aktd.699932

Cited By

Maternal Fed Zinc-Deficient Diet: Effects on Relaxin Family Peptides and Oxidant System in the Testis and Liver Tissue of Male Offspring

Biological Trace Element Research

https://doi.org/10.1007/s12011-024-04113-8

Testis İnişinin Moleküler Mekanizması

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Maternal Fed Zinc-Deficient Diet: Effects on Relaxin Family Peptides and Oxidant System in the Testis and Liver Tissue of Male Offspring