BibTex RIS Kaynak Göster

The Use of Amelogenin Gene in Sex Determination from Human Skeletal Fragments and Teeth Specimens

Yıl 2014, Cilt: 23 Sayı: 4, 606 - 623, 30.10.2014
https://doi.org/10.17827/aktd.45691

Öz

Alternative approaches to sex determination of DNA samples involve investigation of regions of the amelogenin gene. This is the gene that encodes tooth enamel and is present on both the X and Y chromosomes. A review composed via Medline Internet search of literature and contributions from our experiences as well as experiences from colleagues. The rareness of failures in sex determination provides confidence in current techniques, but amelogenin gene method (singly) of sex determination is not without failures. Amelogenin PCR method/system of sex determination should not, at the moment, completely replace traditional methods of sex identification. Hence, sex identification with amelogenin gene, of subjects for forensic purposes should be conducted as much as possible through a multiple morphological-molecular combined methods to avoid fallibility of amelogenin gene.

Kaynakça

  • Sasaki S, Shimokawa H. The amelogenin gene, Int J Dev Biol. 1995;39:127-33.
  • Eastoe JE. The chemical composition of bone and teeth. Adv Fluorine Res Dent Caries Prevent. 1965;3: 5-17.
  • Termine JD, Belcourt AB, Christner PJ, Conn KM, Nylen MU. Properties of dissociatively extracted fetal tooth matrix proteins 1. Principal molecular species in developing bovine enamel. J Biol Chem. 1980;255:9760-68.
  • Lau EC, Mohandas TK, Shapiro LJ, Slavkin HC, Snead ML. Human and mouse amelogenin gene loci are on the sex chromosomes. Genomics. 1989;4:162–8.
  • Shimokawa H, Tamura H, Ibaraki K., Sasaki S. Human amelogenin gene. In Tooth Enamel V (Ed, RW Fearnhead):301-5. Yokohama, Florence Pub, 1989.
  • Sire J-Y, Delgado S, Fromentin D, Grindot M. Amelogenin: lessons from evolution. Arch of Oral Biol. 2005;50:205-12.
  • Yuan ZA, Chen E, Gibson CW. Model system for evaluation of alternative splicing: exon skipping. DNA Cell Biol. 2001;20:807–13.
  • Fincham AG, Bessem CC, Lau EC, Pavlova Z, Shuller C, Slavkin HC et al. Human developing enamel proteins exhibit a sex-linked dimorphism. Calcif Tissue Int 1991;48:288-90.
  • Toyosawa S, O’HUigin C, Figueroa F, Tichy H, Klein J. Identification and characterization of amelogenin genes in monotremes, reptiles, and amphibians. Proc Natl Acad Sci USA. 1998;95:13056–61.
  • Ravindranath RMH, Basilrose RM, Ravindranath NH, Vaitheesvaran B. Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth. J Biol Chem. 2003;278:20293–302. Snead M. Amelogenin protein exhibits a modlar design: Implications for form and function. Connect Tissue Res. 2003;44:47–51.

İnsan İskeleti Parçalarından ve Diş Örneklerinden Amelogenin Genini Kullanarak Cinsiyet Belirleme

Yıl 2014, Cilt: 23 Sayı: 4, 606 - 623, 30.10.2014
https://doi.org/10.17827/aktd.45691

Öz

DNA örneklerindeki cinsiyet tayini için alternatif yaklaşımlardan biri de Amelogenin gen bölgeleridir. X ve Y kromozomlarının üzerinde bulunan bu gen diş minesini de kodlar. Medline araştırma sitesinde makale ve deneyimler taranarak kendi deneyimlerimizin dışında farklı araştırmalarda gözden gecirilmektedir. Mevcut tekniklerle cinsiyet tayini başarısızlıkları seyreklik gösterirken, Amelogenin gen yöntemi tek başına başarılı değildir. Amelogenin PCR yötemi/sisteminde cinsiyet tayini şu anda geleneksel yöntemin yerini almamalıdır. Bu nedenle özellikle adli amaçlı konularda Amelogenin geniyle cinsiyet tayininin yanılınabilirliğini önlemek için bir çok morfolojik-moleküler yöntemle birleştirilerek yapılmalıdır.

Kaynakça

  • Sasaki S, Shimokawa H. The amelogenin gene, Int J Dev Biol. 1995;39:127-33.
  • Eastoe JE. The chemical composition of bone and teeth. Adv Fluorine Res Dent Caries Prevent. 1965;3: 5-17.
  • Termine JD, Belcourt AB, Christner PJ, Conn KM, Nylen MU. Properties of dissociatively extracted fetal tooth matrix proteins 1. Principal molecular species in developing bovine enamel. J Biol Chem. 1980;255:9760-68.
  • Lau EC, Mohandas TK, Shapiro LJ, Slavkin HC, Snead ML. Human and mouse amelogenin gene loci are on the sex chromosomes. Genomics. 1989;4:162–8.
  • Shimokawa H, Tamura H, Ibaraki K., Sasaki S. Human amelogenin gene. In Tooth Enamel V (Ed, RW Fearnhead):301-5. Yokohama, Florence Pub, 1989.
  • Sire J-Y, Delgado S, Fromentin D, Grindot M. Amelogenin: lessons from evolution. Arch of Oral Biol. 2005;50:205-12.
  • Yuan ZA, Chen E, Gibson CW. Model system for evaluation of alternative splicing: exon skipping. DNA Cell Biol. 2001;20:807–13.
  • Fincham AG, Bessem CC, Lau EC, Pavlova Z, Shuller C, Slavkin HC et al. Human developing enamel proteins exhibit a sex-linked dimorphism. Calcif Tissue Int 1991;48:288-90.
  • Toyosawa S, O’HUigin C, Figueroa F, Tichy H, Klein J. Identification and characterization of amelogenin genes in monotremes, reptiles, and amphibians. Proc Natl Acad Sci USA. 1998;95:13056–61.
  • Ravindranath RMH, Basilrose RM, Ravindranath NH, Vaitheesvaran B. Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth. J Biol Chem. 2003;278:20293–302. Snead M. Amelogenin protein exhibits a modlar design: Implications for form and function. Connect Tissue Res. 2003;44:47–51.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Derleme
Yazarlar

Abdullahi Daudu Zagga Bu kişi benim

Hamidu Ahmed Bu kişi benim

Aziz Abdo Tadros Bu kişi benim

Somaia Muhammad Ismail Bu kişi benim

Yayımlanma Tarihi 30 Ekim 2014
Yayımlandığı Sayı Yıl 2014 Cilt: 23 Sayı: 4

Kaynak Göster

AMA Zagga AD, Ahmed H, Tadros AA, Ismail SM. The Use of Amelogenin Gene in Sex Determination from Human Skeletal Fragments and Teeth Specimens. aktd. Aralık 2014;23(4):606-623. doi:10.17827/aktd.45691