Öz
Total body irradiation is used in conjunction with chemotherapy as a conditioning regimen in the treatment of many disease such as leukemia, myelodysplastic syndrome, aplastic anemia, multiple myeloma and lymphoma prior to the hematopoetic stem cell transplantation. The main purposes of the hematopoetic stem cell transplantation are eradication of the recipient bone marrow and any residual cancer cells, creation of space in the receipient bone marrow for donor hematopoetic stem cells, and immunosuppression to prevent rejection of donor stem cells in the case of an allotransplant.
Anahtar Kelimeler
Total body irradiation hematopoietic stem cell transplantation conditioning regimen
Kaynakça
- Roberts KB, Chen Z, Seropian S. Total-Body and Hemibody Irradiation. In Principles and Practice of Radiation Oncology, 5 th ed (Eds EC Halperin, CA. Perez, LW Brady):364-377. Philadelphia, Lippincott Williams &Wilkins. 2008.
- Young JYC, Schultheiss T. Radiotherapeutic principles of hematopoietic cell transplantation. In Thomas' Hematopoietic Cell Transplantation, 4th ed (Eds FR Appelbaum, SJ Forman, RS Negrin, KG Blume):333-350. West Sussex, UK, Wiley-Blackwell. 2009.
- Hartman AR, Williams SF, Dillon JJ. Survival, disease-free survival and adverse effects of conditioning for allogeneic bone marrow transplantation with busulfan/cyclophosphamide vs total body irradiation: a meta-analysis. Bone Marrow Transplant. 1998;22:439-43. Nevill TJ, Barnett MJ, Klingemann HG, Reece DE, Shepherd JD, Phillips GL. Regimen-related toxicity of a busulfan-cyclophosphamide conditioning regimen in 70 patients undergoing allogeneic bone marrow transplantation. J Clin Oncol. 1991;9:1224-32.
- Cosset JM, Socie G, Dubray B, Girinsky T, Fourquet A, Gluckman E. Single dose versus fractionated total body irradiation before bone marrow transplantation: radiobiological and clinical considerations. Int J Radiat Oncol Biol Phys. 1994;30:477-92.
- Devergie A, Blaise D, Attal M, Tigaud JD, Jouet JP, Vernant JP et al. Allogeneic bone marrow transplantation for chronic myeloid leukemia in first chronic phase: a randomized trial of busulfan-cytoxan versus cytoxan-total body irradiation as preparative regimen: a report from the French Society of Bone Marrow Graft (SFGM). Blood. 1995;85:2263-68.
- Socie G, Devergie A, Girinsky T, Reiffers J, Vernant JP, Le Bourgeois JP et al. Influence of the fractionation of total body irradiation on complications and relapse rate for chronic myelogenous leukemia. The Groupe d'Etude des greffes de moelle osseuse (GEGMO). Int J Radiat Oncol Biol Phys. 1991;20:397-404.
- Keane TJ, Van Dyk J. TBI schedules prior to bone marrow transplantation: requirements for comparison. Radiother Oncol. 1989;15:207-12.
- Scarpati D, Frassoni F, Vitale V, Corvo R, Franzone P, Barra S, et al. Total body irradiation in acute myeloid leukemia and chronic myelogenous leukemia: influence of dose and dose-rate on leukemia relapse. Int J Radiat Oncol Biol Phys. 1989;17:547-52.
Öz
Tüm vücut ışınlama hematopoetik kök hücre nakli öncesi kemoterapi ile beraber hazırlık rejimi olarak lösemi, miyelodisplastik sendrom, aplastik anemi, multipl miyelom, lenfoma gibi birçok hastalığın tedavisinde kullanılmaktadır. Hazırlık rejiminin ana amacı alıcı kemik iliği ve olası rezidüel tümör hücrelerini eradike etmek, alıcının kemik iliğinde verici hematopoetik kök hücreleri için yer açmak ve allotransplant durumunda donör kök hücre reddini önlemek için immünsupresyon sağlamaktır.
Anahtar Kelimeler
Tüm vücut ışınlama hematopoetik kök hücre nakli hazırlık rejimi
Kaynakça
- Roberts KB, Chen Z, Seropian S. Total-Body and Hemibody Irradiation. In Principles and Practice of Radiation Oncology, 5 th ed (Eds EC Halperin, CA. Perez, LW Brady):364-377. Philadelphia, Lippincott Williams &Wilkins. 2008.
- Young JYC, Schultheiss T. Radiotherapeutic principles of hematopoietic cell transplantation. In Thomas' Hematopoietic Cell Transplantation, 4th ed (Eds FR Appelbaum, SJ Forman, RS Negrin, KG Blume):333-350. West Sussex, UK, Wiley-Blackwell. 2009.
- Hartman AR, Williams SF, Dillon JJ. Survival, disease-free survival and adverse effects of conditioning for allogeneic bone marrow transplantation with busulfan/cyclophosphamide vs total body irradiation: a meta-analysis. Bone Marrow Transplant. 1998;22:439-43. Nevill TJ, Barnett MJ, Klingemann HG, Reece DE, Shepherd JD, Phillips GL. Regimen-related toxicity of a busulfan-cyclophosphamide conditioning regimen in 70 patients undergoing allogeneic bone marrow transplantation. J Clin Oncol. 1991;9:1224-32.
- Cosset JM, Socie G, Dubray B, Girinsky T, Fourquet A, Gluckman E. Single dose versus fractionated total body irradiation before bone marrow transplantation: radiobiological and clinical considerations. Int J Radiat Oncol Biol Phys. 1994;30:477-92.
- Devergie A, Blaise D, Attal M, Tigaud JD, Jouet JP, Vernant JP et al. Allogeneic bone marrow transplantation for chronic myeloid leukemia in first chronic phase: a randomized trial of busulfan-cytoxan versus cytoxan-total body irradiation as preparative regimen: a report from the French Society of Bone Marrow Graft (SFGM). Blood. 1995;85:2263-68.
- Socie G, Devergie A, Girinsky T, Reiffers J, Vernant JP, Le Bourgeois JP et al. Influence of the fractionation of total body irradiation on complications and relapse rate for chronic myelogenous leukemia. The Groupe d'Etude des greffes de moelle osseuse (GEGMO). Int J Radiat Oncol Biol Phys. 1991;20:397-404.
- Keane TJ, Van Dyk J. TBI schedules prior to bone marrow transplantation: requirements for comparison. Radiother Oncol. 1989;15:207-12.
- Scarpati D, Frassoni F, Vitale V, Corvo R, Franzone P, Barra S, et al. Total body irradiation in acute myeloid leukemia and chronic myelogenous leukemia: influence of dose and dose-rate on leukemia relapse. Int J Radiat Oncol Biol Phys. 1989;17:547-52.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Ekim 2014 |
| Yayımlandığı Sayı | Yıl 2014 Cilt: 23 Sayı: 3 |
