Ocular Graft Versus Host Disease

Yıl 2014, Cilt: 23 Sayı: 3, 484 - 491, 30.10.2014

Elif Erdem Meltem Yagmur

https://doi.org/10.17827/aktd.30227

Öz

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important therapeutic procedure for the treatment of hematologic malignancies. Graft-versus-host disease (GVHD) is a common cause of morbidity and mortality after allo-HSCT. Severe systemic form of GVHD may become life threatening. Ocular involvement of GVHD remains the most common cause of long-term morbidity.In this review article, the etiology, pathophysiology, clinical features, and treatment modalities of ocular GVHD are presented.

Anahtar Kelimeler

Ocular Graft Versus Host Disaese, dry eye

Oküler Graft Versus Host Hastalığı

Öz

Allojenik hematopoetik kök hücre nakli (allo-HKHN), hematolojik malignitelerin tedavisinde önemli bir terapötik yöntemdir. Graft-versus-host hastalığı (GVHH), allo-HKHN sonrası morbidite ve mortalitenin sık görülen bir nedenidir. GVHH'nın ciddi sistemik formu hayatı tehlit edebilir. GVHH'nın göz tutulumu ise uzun dönemdeki morbiditenin en yaygın nedenidir.Bu derleme makalede, oküler GVHH'nın etyolojisi, patofizyolojisi, klinik özellikleri ve tedavi seçenekleri sunulmaktadır.

Anahtar Kelimeler

Oküler Graft Versus Host hastalığı, kuru göz

Kaynakça

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