BibTex RIS Kaynak Göster

Clinical Pharmacokinetic and Pharmacodynamic Profile of Cinacalcet

Yıl 2014, Cilt: 23 Sayı: 2, 362 - 365, 30.10.2014
https://doi.org/10.17827/aktd.98405

Öz

The purpose of this letter is to explain clinical pharmacokinetic, pharmacodynamic profile and indication of cinacalcet therapy particularly in chronic kidney disease. Chronic kidney disease and progressive renal failure are associated with phosphate retention and impaired formation of active vitamin D, or calcitriol (1α-25-dihydroxyvitamin D), leading to hypocalcemia, increased secretion of parathyroid hormone, and, eventually, hyperplasia of the parathyroid gland. Secondary hyperparathyroidism is frequent and progresses over time in patients with chronic kidney disease. It develops as a result of disturbance in parathyroid hormone, calcium, phosphate, and vitamin D homeostasis. Risk factors are mainly hyperphosphatemia and increased calcium-phosphate products1. The related mineral and bone disorders are early onset, common and serious complications because of their significant impact on morbidity and mortality due to skeletal (renal osteodystrophy, loss of bone mineral density, bone pain, and fractures) and extra skeletal manifestations particularly cardiovascular manifestations2,3. Conventional treatment with a calcium supplement, phosphate binders and active vitamin D derivatives lead in part to amelioration of secondary hyperparathyroidism, but are simultaneously associated with unacceptable side-effects, including hypercalcemia, hyperphosphatemia, and increased calcium-phosphate products1

Kaynakça

  • Ogata H, Koiwa F, Ito H, Kinugasa E. Therapeutic strategies for secondary hyperparathyroidism in dialysis patients. Ther Apher Dial. 2006; 10:355-63. Arşiv Kaynak Tarama Dergisi . Archives Medical Review Journal

Cinacalcet'in Klinik Farmakokinetik ve Farmakodinamik Profili

Yıl 2014, Cilt: 23 Sayı: 2, 362 - 365, 30.10.2014
https://doi.org/10.17827/aktd.98405

Öz

Özet bulunmuyor

Kaynakça

  • Ogata H, Koiwa F, Ito H, Kinugasa E. Therapeutic strategies for secondary hyperparathyroidism in dialysis patients. Ther Apher Dial. 2006; 10:355-63. Arşiv Kaynak Tarama Dergisi . Archives Medical Review Journal
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derleme
Yazarlar

Karima Boubaker Bu kişi benim

Hafedh Hedri Bu kişi benim

Adel Kheder Bu kişi benim

Yayımlanma Tarihi 30 Ekim 2014
Yayımlandığı Sayı Yıl 2014 Cilt: 23 Sayı: 2

Kaynak Göster

AMA Boubaker K, Hedri H, Kheder A. Cinacalcet'in Klinik Farmakokinetik ve Farmakodinamik Profili. aktd. Haziran 2014;23(2):362-365. doi:10.17827/aktd.98405