Öz
Hemoglobinopathies include an enormous patient population in south part of Turkey. Allogeneic hematopoietic stem cell transplantation is only curative treatment in thalassemia. Optimal medical therapy is very important in the years before transplant to achieve a successful transplantation. In this study, the indications, risk factors, results and the situation related with hematopoietic stem cell transplantation in thalassemia in Turkey was reviewed.
Anahtar Kelimeler
thalassemia hematopoietic stem cell transplantation children
Kaynakça
- Smiers FJ, Krishnamurti L, Lucarelli G. Hematopoietic stem cell transplantation for hemoglobinopathies: current practice and emerging trends. Pediatr Clin North Am. 2010; 57:18120
- Thomas ED, Buckner CD, Sanders JE, Papayannopoulou T, Borgna-Pignatti C, De Stefano P et al. Marrow transplantation for thalassemia. Lancet. 1982; 2:227-8.
- Lucarelli G, Galimberti M, Polchi P, Angelucci E, Baronciani D, Giardini C et al. Bone marrow transplantation in patients with thalassemia. N Eng J Med. 1990; 322:417-21. Mathews V, George B, Deotare U, Lakshmi KM, Viswabandya A, Daniel D et al. A new stratification strategy that identifies a subset of class III patients with an adverse prognosis among children with beta thalassemia major undergoing a matched related allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2007; 13:889-94.
Öz
Hemoglobinopatiler ülkemizin özellikle güney bölümünde önemli bir hasta populasyonunu kapsamaktadır. Talasemide küratif tek tedavi yöntemi allojenik hematopoetik kök hücre naklidir. Nakilden önceki yıllarda uygun medikal tedavinin verilmesi transplantın başarısı açısından çok önemlidir. Bu yazıda talasemideki kök hücre nakli ile ilgili endikasyonlar, risk faktörleri, sonuçlar ve Türkiye'deki durum gözden geçirilmiştir.
Anahtar Kelimeler
Kaynakça
- Smiers FJ, Krishnamurti L, Lucarelli G. Hematopoietic stem cell transplantation for hemoglobinopathies: current practice and emerging trends. Pediatr Clin North Am. 2010; 57:18120
- Thomas ED, Buckner CD, Sanders JE, Papayannopoulou T, Borgna-Pignatti C, De Stefano P et al. Marrow transplantation for thalassemia. Lancet. 1982; 2:227-8.
- Lucarelli G, Galimberti M, Polchi P, Angelucci E, Baronciani D, Giardini C et al. Bone marrow transplantation in patients with thalassemia. N Eng J Med. 1990; 322:417-21. Mathews V, George B, Deotare U, Lakshmi KM, Viswabandya A, Daniel D et al. A new stratification strategy that identifies a subset of class III patients with an adverse prognosis among children with beta thalassemia major undergoing a matched related allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2007; 13:889-94.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Ekim 2014 |
| Yayımlandığı Sayı | Yıl 2014 Cilt: 23 Sayı: 1 |
