Hematopoietic Stem Cell Transplantation in Pediatric Myelodysplastic Syndromes

Yıl 2014, Cilt: 23 Sayı: 1, 82 - 89, 30.10.2014

Gülay Sezgin

https://doi.org/10.17827/aktd.41632

Öz

Myelodysplastic syndromes (MDSs) are a heterogenous group of hemopoietic clonal disorders characterized by ineffective hemopoiesis and frequent evolution to leukemia.They are rare entities, particularly in children.Recently,they have been classified into 3 major groups: MDS, juvenile myelomonocytic leukemia, and Down syndrome–associated myeloid leukemia.Haematopoietic stem cell transplantation(HSCT) is the treatment of choice and results in cure rates of around 60%.

Anahtar Kelimeler

hematopoietic stem cell transplantation, children, MDS, JMML, RAEB

Pediatrik Miyelodisplastik Sendromunda Kök Hücre Nakli

Öz

Miyelodisplastik sendromlar inefektif hematopoez,lösemi gelişme riski ile karakterize klonal heterojen bir hastalık grubudur. Çocuklarda nadiren görülür.Yakın zamanda yapılan sınıflamada 3 ana hastalık tanımlamaktadır: Jüvenil miyelomonositik lösemi (JMML),Down sendromunun miyeloid lösemisi (MDS,geçici miyeloproliferatif hastalık, ve akut miyeloid lösemi) ve MDS. Hematopoietik kök hücre nakli tek tedavi seçeneği olup, kür %60 olarak bildirilmiştir.

Anahtar Kelimeler

hematopoietik kök hücre nakli, MDS, RAEB, JMML, çocukluk çağı

Kaynakça

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