Öz
Neurological diseases are characterized by loss of cells in response to an injury or a progressive insult. In recent years, neurons and glia have been generated successfully from stem cells in cultures, fuelling efforts to develop stem-cell-based transplantation therapies for human neurological diseases, such as Parkinson disease, stroke or neuromuscular disorders. In this review, the potential of various cell therapies in childhood neurological diseases are discussed.
Anahtar Kelimeler
Kaynakça
- Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature. 2006; 441:1094-96.
- Kishk N, Abokrysha N. Stem Cell in Neurological Disorders. Stem Cells in Clinic and Research 2011: 363-400.
- Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nature Med. 2004; 10(Suppl):42-50. Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y et al. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest. 2004; 113:1701-10.
- Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y et al. Dopaminergic neurons generated from monkey embryonic stem cell function in a Parkinson primate model. J Clin Invest. 2005; 115:102-9.
Öz
Nörolojik hastalıklar, sıklıkla nöronlarda kayıp veya progresif hasar nedeniyle oluşur. Son yıllarda kök hücre teknikleri ile gerek nöron, gerekse gliaların üretilmesi mümkün olmuş, bu gelişmelere paralel olarak da Parkinson, stroke, kas hastalıkları gibi pek çok nörolojik hastalığın tedavisinde kullanım çalışmaları başlamıştır. Bu yazıda, çocukluk döneminde çeşitli nörolojik hastalıkların tedavisinde hücre tedavilerinin rolü tartışılmıştır.
Anahtar Kelimeler
Kaynakça
- Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature. 2006; 441:1094-96.
- Kishk N, Abokrysha N. Stem Cell in Neurological Disorders. Stem Cells in Clinic and Research 2011: 363-400.
- Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nature Med. 2004; 10(Suppl):42-50. Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y et al. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest. 2004; 113:1701-10.
- Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y et al. Dopaminergic neurons generated from monkey embryonic stem cell function in a Parkinson primate model. J Clin Invest. 2005; 115:102-9.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Ekim 2014 |
| Yayımlandığı Sayı | Yıl 2014 Cilt: 23 Sayı: 1 |
