Öz
Transplant-associated thrombotic microangiopathy is a bothersome complication in terms of morbidity and mortality after allogeneic stem cell transplantation. It is believed that the endothelial injury causes to thrombotic microangiopathy, but the pathogenesis is not known completely. Although there is a consensus about diagnostic criteria, there is no concurrence for the treatment particularly. Even though thrombotic microangiopathy is considered by transplantation physician recently, adequate prospective multi-center studies and broad serial cases are not presented yet.
Anahtar Kelimeler
thrombotic microangiopathy allogeneic stem cell transplantation children
Kaynakça
- Powles RL, Clink HM, Spence D, Morgenstern G, Watson JG, Selby HJ et al. Cyclosporine A to prevent graft-versus-host disease in man after allogeneic bone marrow transplantation. Lancet. 1980; 1:327-9.
- George JN, Li X, McMinn JR, Terrell DR, Vesely SK, Selby GB. Thrombotic thrombocytopenic purpura – hemolytic uremic syndrome following allogeneic HPC transplantation: a diagnostic dilemma. Transfusion. 2004; 44:294-304.
- Ruutu T, Barosi G, Benjamin RJ, Clark RE, George JN, Grathwohl A et al. Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica. 2007; 92:95-100.
- Batts ED, Lazarus HM. Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress ora re we waiting? Bone Marrow Transplant. 2007; 40:709-19. Erbey F. Transplant-associated thrombotic microangiopathy in childhood. In Microangiopathy (Ed De Cristafaro):9-22.. Croatia, In Tech. 2012
- Erbey F, Bayram I, Yilmaz S, Tanyeli A. The overview of diagnostic criteria and treatment options of transplantation associated thrombotic microangiopathy with two case reports. Int J Hematol Oncol. 2010; 20:110-4.
Öz
Transplant ilişkili trombotik mikroanjiopati, hematopoetik kök hücre nakli sonrası morbidite ve mortalite açısından oldukça can sıkıcı bir komplikasyon olarak karşımıza çıkmaktadır. Olayı endotel hasarının başlattığına inanılmakla birlikte patogenez tam olarak bilinmemektedir. 2007 yılında tanı kriterleri açısından fikir birliği sağlanmasına rağmen, özellikle tedavi konusunda henüz bir fikir birliği bulunmamaktadır. Son yıllarda transplant hekimleri tarafından bu klinik komplikasyon daha fazla akıllara gelmekle birlikte, henüz yeterli prospektif, çok merkezli ve geniş olgu serilerinin yer aldığı çalışmalar bulunmamaktadır.
Anahtar Kelimeler
trombotik mikroanjiopati hematopoetik kök hücre nakli çocukluk çağı
Kaynakça
- Powles RL, Clink HM, Spence D, Morgenstern G, Watson JG, Selby HJ et al. Cyclosporine A to prevent graft-versus-host disease in man after allogeneic bone marrow transplantation. Lancet. 1980; 1:327-9.
- George JN, Li X, McMinn JR, Terrell DR, Vesely SK, Selby GB. Thrombotic thrombocytopenic purpura – hemolytic uremic syndrome following allogeneic HPC transplantation: a diagnostic dilemma. Transfusion. 2004; 44:294-304.
- Ruutu T, Barosi G, Benjamin RJ, Clark RE, George JN, Grathwohl A et al. Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica. 2007; 92:95-100.
- Batts ED, Lazarus HM. Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress ora re we waiting? Bone Marrow Transplant. 2007; 40:709-19. Erbey F. Transplant-associated thrombotic microangiopathy in childhood. In Microangiopathy (Ed De Cristafaro):9-22.. Croatia, In Tech. 2012
- Erbey F, Bayram I, Yilmaz S, Tanyeli A. The overview of diagnostic criteria and treatment options of transplantation associated thrombotic microangiopathy with two case reports. Int J Hematol Oncol. 2010; 20:110-4.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Ekim 2014 |
| Yayımlandığı Sayı | Yıl 2014 Cilt: 23 Sayı: 1 |
