Matriks Metalloproteinaz Enzim Ailesi

Yıl 2013, Cilt: 22 Sayı: 2, 209 - 220, 01.06.2013

Özlem Görüroğlu Öztürk

Öz

Matriks metalloproteinazlar, embriyogenezis, doku yeniden yapılandırılması, yara iyileşmesi ve anjiyogenezis gibi pek çok biyolojik süreçte ve ateroskleroz, artrit ve kanser gibi patolojik durumda önemli rol oynamaktadırlar. Bügüne kadar insanlarda, farklı grup matriks metalloproteinaz enzimlerini kodlayan 24 gen tanımlanmıştır. Bu derlemede, matriks metalloproteinaz ailesinin üyeleri, bunların substrat özgüllüğü, yapıları, fonksiyonları ve enzim aktivitelerinin doku inhibitörleri ile düzenlenmesi tartışılmıştır.

Anahtar Kelimeler

Doku inhibitörleri, jelatinaz, kollojenaz, matriks metalloproteinaz

Matrix Metalloproteinase Enzyme Family

Öz

Matrix metalloproteinases play an important role in many biological processes such as embriogenesis, tissue remodeling, wound healing, and angiogenesis, and in some pathological conditions such as atherosclerosis, arthritis and cancer. Currently, 24 genes have been identified in humans that encode different groups of matrix metalloproteinase enzymes. This review discuss the members of the matrix metalloproteinase family and their substrate specificity, structure, function and the regulation of their enzyme activity by tissue inhibitors.

Anahtar Kelimeler

Collogenase, gelatinase, matrix metalloproteinase, tisue inhibitors

Kaynakça

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