Role of Myeloperoxidase in Stroke

Yıl 2013, Cilt: 22 Sayı: 1, 1 - 11, 01.03.2013

Arzu Tay Yusuf Tamam

Öz

Ischemic stroke is a significant pathological state which results from sudden infract in brain tissue. Most common cause of ischemic stroke is atherosclerosis. It is the most common cause of mortality in developed countries. Atherosclerosis has been purposed to be a chronic inflammatory disease. There is significant association between inflammatory process and ischemic events. Oxidative stress and inflammation significantly contribute to development of atherosclerosis. Myeloperoxidase enzyme is a lysosomal enzyme secreted from leucocytes as a response to oxidative stress. MPO which has been abundantly present in leucocytes, forms reactive oxidant products and plays role in atherosclerotic reactions thorough its catalytic activity.

Anahtar Kelimeler

ischemic stroke, myeloperoxidase, atherosclerosis, inflammation, oxidative stress

İnmede Myeloperoksidazın Rolü

Öz

İskemik inme, beyin dokusunda meydana gelen infarkt nedeni ile ani olarak ortaya çıkan patolojik bir durumdur. İskemik inmenin en önemli nedeni aterosklerozdur. Gelişmiş ülkelerdeki en sık ölüm nedeni aterosklerozdur. Aterosklerozun kronik bir inflamatuar hastalık olduğu düşünülmektedir. İnflamasyon süreciyle iskemik olaylar arasında ilişki vardır. Oksidatif stres ve inflamasyon, aterosklerozun patogenezine katkıda bulunur. Miyeloperoksidaz enzimi, oksidatif strese yanıt olarak lökositlerden salgılanan lizozomal bir enzimdir. Lökositlerde bolca bulunan ve reaktif oksidan ürünler oluşturan miyeloperoksidaz enzimi aterosklerotik reaksiyonlarda bulunur ve katalitik aktivite gösterir.

Anahtar Kelimeler

Akut iskemik inme, miyeloperoksidaz, ateroskleroz, inflamasyon, oksidatif stres

Kaynakça

• Ropper AH, Brown RH. Adams and Victor‘s Principles of Neurology, 9 th edition. New York, Mc Graw-Hill, 2005.
• Utku U, Çelik Y. Strokta etyoloji, sınıflandırma ve risk faktörleri. Balkan S: Serebrovaskuler Hastalıklar. Güneş Kitabevi Yayınları, Ankara. 2002; 49-61.
• Sacco PL. Vascular diseases. Ed: Merrit, Rowland LP, Merrit‘s Neurology 10. Baskı, Hagerstown. Williams&Wilkins. 2000; 177-85.
• Kim JS. Cytokines and adhesion molecules in stroke and related diseases. J Neurol Sci. 1996;137: 69Arvin B, Neville LF, Barone FC, Feuerstein GZ. The rol of inflamation and cytokines in brain injury. Neurosci Biobehav Rev. 1996: 20: 445-52.
• Ridker PM, Cushman M, Stampfer MJ. Inflammation, aspirin and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997; 336: 973-79.
• Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women . N Engl J Med. 2000; 342: 836Geisler T, Bhatt DL. The role of inflammation in atherothrombosis: current and future strategies of medical treatment. Med Sci Monit. 2004;10:308-16.
• Di Napoli M, Papa F. Prognostic influence of increased c-reactive protein and fibrinogen levels in ischemic stroke. Stroke. 2001;32:133-38.
• Canova CR, Courtin C, Reinhart WH. C-reactive protein (CRP) in cerebrovascular events. Atherosclerosis. 1999;147:49–53.
• Apple FS, Wu AH, Mair J, Ravkilde J, Panteghini M, Tate J et al. Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem. 2005; 51:810-24.
• Mullane KM, Kraemer R, Smith B. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods .1975;14:157-67.
• Lindsberg PJ, Grau AJ. Inflammation and infections as risk factors for ischemic stroke. Stroke. 2003; 34:2518-32.
• Voorend M, Faber CG, Ven AJ.A.M, Kessels F, Bruggeman CA, Lodder J. Chlamydia pneumoniae is a likely risk factor for ischemic stroke in young patients. J Stroke Cerebrovasc Dis. 2004;13:85-91. Tarnacka B, Gromadzka G, Czlonkowska A. Increased circulating immune complexes in acute stroke:the triggering role of Chlamydia pneumoniae and cytomegalovirus. Stroke. 2002; 33:936
• Daugherty A, Dunn JL, Rateri DL, Heinecke JW. Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J Clin Invest. 1994; 94: 437-44.