Current Medical Treatment of StableCoronary Artery Disease

Yıl 2015, Cilt: 24 Sayı: 4, 592 - 613, 15.09.2015

Göknur Tekin , Abdullah Tekin

https://doi.org/10.17827/aktd.91590

Öz

Coronary artery disease is the leading cause of death in the world. Despite the increasing success of conventional medical therapies and the continued development and improvement of percutaneous coronary intervention, a significant number of patients with ischemic heart disease and angina pectoris cannot be successfully managed. There are two major purposes in the treatment of stable angina. The first is to prevent myocardial infarction and death and thereby, increase the quantity of life. The second is to reduce symptoms of angina and the frequency and severity of ischemia, which should improve the quality of life. Antiischemic agents, including beta-blockers, nitrates and calcium channel blockers, remain the mainstay in the prevention of angina. Also new pharmacological options for refractory angina, metabolic agents, and vasodilator therapies are adding to the armamentarium to prevent and treat angina. This review will summarize current recommended pharmacological approachesof stable coronary artery disease, with a focuson novel therapies.

Anahtar Kelimeler

Stable angina, antiischemic medications, coronary artery disease

Kararlı Koroner Arter Hastalığında Güncel İlaç Tedavisi

Öz

Koroner arter hastalığı tüm dünyadaki ölümlerin en yaygın sebebidir. Hem tıbbi tedavi, hem de perkütan koroner arter girişimdeki artan yeni gelişmelere rağmen, halen birçok iskemik kalp hastalığı olan hastanın semptomları yeterli düzeyde kontrol altına alınamamaktadır. Kararlı angina tedavisinin iki önemli amacı vardır. Birincisi, miyokard infarktüsü ve ölümü engelleyerek yaşam beklentisini uzatmak, ikincisi de anginanın sıklığını ve şiddetini azaltarak hayat kalitesini arttırmaktır. Beta blokerler, kalsiyum antigonistleri ve nitratlar antiiskemik tedavinin temelini oluştururken, refrakter angina için kullanılan yeni farmakolojik seçenekler, metabolik ajanlar ve vazodilatatör ilaçlar anginanın önlenmesi ve tedavisinde kullanılan silahlar arasına katılmaktadırlar. Bu derlemede kararlı koroner arter hastalığının güncel medikal tedavisi yeni ajanlar ışığı altında özetlenecektir

Anahtar Kelimeler

Kararlı angina, antiiskemik ilaçlar, koroner arter hastalığı

Kaynakça

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• Correspondence Address / Yazışma Adresi