Trisiklik Antidepresanlarla Zehirlenme ve Güncel Tedaviler

Yıl 2016, Cilt: 25 Sayı: 4, 608 - 617, 31.12.2016

Müge Gülen

https://doi.org/10.17827/aktd.253568

Cited By: 2

Öz

Tüm antidepresanlarla olan zehirlenmelerde trisiklik antidepresanlar morbidite ve mortalitenin ana nedenlerinden biridir. Trisiklik antidepresanların başlıca toksik etkileri kardiyovasküler sistem ve santral sinir sistemi üzerine olup, antikolinerjik belirtilerle kendini gösterir. Tedavide kullanılacak bilinen bir antidot yoktur. Ancak ventriküler aritmilerin ve hipotansiyonun önlenmesinde ve metabolik asidozun düzelmesinde sodyum bikarbonat tedavisi oldukça etkindir. Semptomların giderilmesinde kullanılan ve halen araştırma aşamasında olan bazı tedavi yöntemleri bulunmaktadır. Kullanılacak ilaçlar hastanın semptomlarına göre özelleştirilebilir.

Anahtar Kelimeler

Trisiklik antidepresanlar, zehirlenme, acil

Poisoining with Tricyclic Antidepressants and Current Treatment

Öz

Poisoning with tricyclic antidepressants is one of the main causes of morbidity and mortality compared to all the antidepressants. Main toxic effects are on the cardiovascular system and central nervous system and manifests itself as anticholinergic symptoms. There is no antidote known to be used in the treatment. But sodium bicarbonate treatment is effective in preventing ventricular arrhythmias and hypotension, and resolving metabolic acidosis. There are some treatments that has been used for relief of symptoms and some of them still are in research stage. The drugs that are used can be customized according to the patients symptoms.

Anahtar Kelimeler

Tricyclic antidepressants, poisoining, emergency

Kaynakça

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• Correspondence Address / Yazışma Adresi Müge Gülen
• Adana Numune Eğitim ve Araştırma Hastanesi
• Acil Tıp Kliniği, Adana, Turkey
• e-mail: [e-mail]
• Geliş tarihi/ Received: 14.04.2016
• Kabul tarihi/Accepted: 23.05.2016