Effect of Kruppel-like Transcription Factor KLF1 on HbA2 and HbF Values

Yıl 2017, Cilt: 26 Sayı: 3, 342 - 351, 30.09.2017

Gülüzar Özbolat Abdullah Tuli

https://doi.org/10.17827/aktd.303591

Öz

Krüppel-like factors are a family of transcription factors capable of binding GC-rich sequences, have emerged as critical regulators of functions  that play important roles in many fundamental biologic processes, including development, proliferation, differentiation and apoptosis. KLF1 (EKLF) was the first KLF member to be discovered. It is an erythroid-specific transcription factor that is essential for erythropoiesis. In this review, we first give information about the structure, functions and variants of KLF1. The effects of KLF1 on fetal hemoglobin (HbF) and hemoglobin A2 (HbA2) values will be discussed.

Anahtar Kelimeler

KLF1, HbF, HbA2, transcription

Kruppel Benzeri Transkripsiyon Faktör KLF1’in HbA2 ve HbF Değerlerine Etkisi

Öz

Krüppel benzeri faktörler, GC bakımından zengin sekansları bağlayabilen transkripsiyon faktörleri ailesidir ve gelişme, çoğalma, farklılaşma ve apoptoz gibi birçok temel biyolojik süreçte önemli rol oynayan fonksiyonların kritik düzenleyicileri olarak ortaya çıkmıştır.  KLF1 (EKLF) keşfedilen ilk KLF üyesiydi. Eritropoez için gerekli olan eritroide özel bir transkripsiyon faktörüdür. Bu derlemede, öncelikle KLF1’ in yapısı, görevleri ve varyantları hakkında bilgi aktarılıp KLF1’in Fetal hemoglobin (HbF) ve Hemoglobin A2 (HbA2) değerleri üzerine etkileri tartışılacaktır.

Anahtar Kelimeler

KLF1, HbF, HbA2, transkripsiyon

Kaynakça

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