Clinical Use of Neuronal Growth Factors in Neurodevelopmental Disorders

Yıl 2019, Cilt: 28 Sayı: 2, 98 - 107, 30.06.2019

Miraç Barış Usta , Murat Terzi , Koray Karabekiroğlu , Armağan Aral

Öz

Neurodevelopmental disorders are disorders that cause severe dysfunction. These disorders begin in early childhood and have many complex etiologies that are not yet enlightened today. There are hypotheses and some evidence that in neurodevelopmental disorders about abnormal growth factor expression during embryogenesis. Recent studies have been reported that neuronal growth factors may also related to clinical conditions in this disorders. Along with increased evidence, changes in neuronal growth factor levels indicate common pathophysiological mechanisms between Attention Deficit and Hyperactivity Disorder and Autism Spectrum Disorder. Therefore, the investigation of all these related pathways and growth factors will lead to possible clinical uses of these neuronal growth factors for Attention Deficit and Hyperactivity Disorder and Autism Spectrum Disorder.

Anahtar Kelimeler

attention deficit and hyperactivity disorder, autism spectrum disorder, neuronal growth factors, biomarker

Nörogelişimsel Bozukluklarda Nöronal Büyüme Faktörlerinin Klinik Kullanımı

Öz

Nörogelişimsel bozukluklar, ciddi işlev kaybına neden olan bozukluklardır. Bu bozukluklar erken çocuklukta başlar ve bir çoğu henüz aydınlatılmamış kompleks etiyolojilere sahiptirler. Bir çok nörogelişimsel hastalıkta, embriyogenez esnasında anormal büyüme faktörü ekspresyonu olduğuna dair hipotez ve kanıtlar bulunmaktadır. Son yıllarda nöronal büyüme faktörlerininin klinik durumlarlada ilişkili olabileceğine dair bulgular bildirilmiştir. Artan kanıtlar ile beraber, nöronal büyüme faktör düzeylerindeki değişimler Dikkat Eksikliği ve Hiperaktivite Bozukluğu ve Otizm Spektrum Bozukluğu arasındaki ortak patofizyolojik mekanizmaları işaret etmektedir. Bu nedenle tüm bu ilişkili yolakların ve büyüme faktörlerinin araştırılması Dikkat Eksikliği ve Hiperaktivite Bozukluğu ve Otizm Spektrum Bozukluğu için bu nöronal büyüme faktörlerin olası klinik kullanımları için yol gösterecektir.

Anahtar Kelimeler

dehb, biyolojik belirteç, nöronal büyüme faktörü, otizm spektrum bozukluğu

Kaynakça

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