Hidrojellerin Tıpta Uygulamaları

Yıl 2020, Cilt: 29 Sayı: 2, 129 - 137, 30.06.2020

Ayşe Ulusoy , Nurten Dikmen

https://doi.org/10.17827/aktd.603432

Cited By: 1

Öz

Hidrojeller
“Smart (akıllı)” yapılar olarak tanımlanan ilaç taşınım sistemleri, enjekte
edilebilen polimer sistemleri, doku mühendisliği ve hücre enkapsülasyonu gibi
tıpta yaygın olarak kullanılan polimerlerdir. Hidrojeller suyu yapılarında
tutabilme özellikleri, yumuşak ve esnek yapıda olmaları ile canlı dokulara
büyük benzerlik göstermektedirler. Toksisitesi olmayan, biyolojik olarak
parçalanan ve biyolojik uyum gösterebilen yapıları sebebiyle hidrojellerin
biyomalzeme olarak kullanılması giderek güvenli hale gelmektedir. Aynı zamanda
hidrojellerin kontrollü serbest bırakma mekanizması, ilacın salınım hızını
düzenleyen geleneksel dozaj yöntemleri karşısında birçok avantaj sağlamaktadır.
Bu derlemede genel olarak yara örtüsünde, yanık, anevrizma tedavilerinde, kemik
rejenerasyonunda, kardiyak doku onarım ve rejenerasyonunda, kontrollü ilaç
salınımında, kontakt lenslerde, glokom tedavisinde kullanılan ve biyolojik
araştırmaları devam etmekte olan hidrojellerden bahsedilmektedir.

Anahtar Kelimeler

hidrojel, kontrollü salınım mekanizması, doku mühendisliği, biyomalzeme

Teşekkür

Hidrojeller konusuna yönlenmem sürecinde fikirlerini esirgemeyen ve yeni ufuklar açan Doç.Dr. Burcu Okutucu’ya sonsuz teşekkürlerimi sunarım.

Kaynakça

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